... 9041–9046.32 Jensson O, Palsdottir A, Thorsteinsson L, Arnason A, Abrahamson M, Olafsson I & Grubb A (1990) CystatinC mutation causing amyloid angiopathy and brainhemorrhage. Biol Chem Hoppe ... undergoes a conform-ational change and amyloid fibril formation. We show that copper bindinginhibits the amyloid fibril formation and, to a lesser degree, the initialaggregation. Similarities to and ... aggregation and amyloid fibril forma-tion of a pathological mutant (in inherited diseases), orof a normal protein or its normal variant (in sporadiccases). Amyloid fibril formation is regarded as a...