... [32]. The Lsm1 and Lsm8 polypeptides are most similar in the regions of the Sm1 and Sm2 motifs. These motifsform the Sm-fold, the hallmark of the Sm-like pro-teins, consisting of a five-stranded ... sequences from other Lsm subunits, most likely the neighbouring Lsm2p and ⁄ or Lsm4p. Alternatively,Lsm1p and Lsm8p may affect the conformation of other subunits and ⁄ or of the entire complex, ... [26,27] and in P-body assembly [28],emphasizing the importance of residues outside Lsm1p and Lsm8p for the localization and function of thesecomplexes.In budding yeast, only one form of the homologousSm...