... of an isoform of PP1, PP1a [3].Similarly, activation of caspase-8 and -3 is regulatedthrough their phosphorylation and dephosphorylation.Phosphorylation of caspase-8 at Tyr397 and Tyr465 by Lyn, ... MAPKERK1153755PPPp53Fig. 1. Regulation of DNA fragmentation by phosphorylation of the MAPK family and mitochondrial proteins. Phosphorylated ERK preventsthe activation of caspases and the Bcl-2 family, ... antiapoptotic proteins(Bcl-2, Bcl-xL, Bcl-w, Mcl-1 and A1), pro-apoptoticproteins (Bax, Bak and Bok) and BH3-only proteins(Bad, Bid, Bik, Blk, Hrk, BNIP3 and BimL). Bcl-2family proteins mostly...