... mitochondrialdysfunction and death. Science 292, 72 7–7 30.4 Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG& Youle RJ (1997) Movement of Bax from the cytosol to mitochondria during apoptosis. ... proteins, such as cytochrome c,which are released into the cytoplasm as a consequenceof apoptotic signals. The release of these apoptoticfactors involves alteration of the mitochondrial outermembrane ... soluble in the cytoplasm, itsapoptotic activation includes extensive structural reor-ganization, which facilitates targeting to, and insertioninto, the mitochondrial outer membrane [ 4–6 ]. The lat-ter...