... of the Bcl-2 family, and the forkhead transcription factor FKHR [25], a proapoptotic tran-scription factor, thereby inhibiting them, the PtdIns3-K ⁄ Akt signaling pathway has emerged as the ... shownthat the bcl-X gene has consensus sequences for the binding of several transcription factors, includingNF-jB, AP1, and GATA-1 [29,30]. In response to asuitable signal such as growth factors, the ... AP1 DNA binding activity increasedwithin 1 h following EGF treatment and peaked at 3 hfollowing the treatment (Fig. 5A). We also examined the effect of PD98059 on this binding activity and, asexpected,...