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Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx

Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx

Báo cáo khoa học: The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations docx

... 2004 The HNF1b transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations Guizhi Wu, Silvia Bohn and Gerhart U. RyffelInstitut ... potential of the POUS and POUH domains of HNF1b. Domains of HNF1b involved in nephrogenesis The simplicity14of the Xenopus system allowed us todifferentiate the properties of the HNF1a and HNF1b proteins ... three domains of the HNF1b protein that interfere with pronephric d evelopmentwhen swapped into the HNF1a protein. These include the dimerization domain, the 26 a a segment and the homeo-domain....
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc

Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc

... transcription factors in the regulation of prostaglandin G ⁄ H synthase2 expression by interleukin-1 in osteoblastic MC3T3–E1cells. J Bone Miner Res 15, 1138–1146.6 Iniguez MA, Martinez-Martinez S, ... Manning C, Akbarali Yet al. (2003) Responses to the proinflammatory cyto-kines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other jointtissues involve ... Wepresent here a novel role for the Ets transcription factor ESE-1 in regula-ting the COX-2 gene in response to endotoxin and other pro -in ammatorystimuli. We report that the induction of COX-2 expression...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc

Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc

... of the Bcl-2 family, and the forkhead transcription factor FKHR [25], a proapoptotic tran-scription factor, thereby inhibiting them, the PtdIns3-K ⁄ Akt signaling pathway has emerged as the ... shownthat the bcl-X gene has consensus sequences for the binding of several transcription factors, includingNF-jB, AP1, and GATA-1 [29,30]. In response to asuitable signal such as growth factors, the ... AP1 DNA binding activity increasedwithin 1 h following EGF treatment and peaked at 3 hfollowing the treatment (Fig. 5A). We also examined the effect of PD98059 on this binding activity and, asexpected,...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... E2F4 ⁄ 5 and DP1 ⁄ 2 and a module containing the MuvB proteins Lin-37, Lin-52, Lin-54 and chromatin-associated Lin-9 and Lin-53 ⁄ RBBP4 ⁄ RbAp48.Furthermore, A-Myb and B-Myb were present in immunoprecipitations ... [87].However, the limitation of ChIP analyses is that the exact binding location is not identified in the experi-ments. Therefore, it is not clear whether the CDE ⁄ CHRis involved in binding these factors.Consistent ... -2 and -3. These acti-vating E2Fs cooperate with NF-Y proteins binding toCCAAT-boxes and with Myb proteins associating witha distal Myb site in activating the Cdc2 promoter.Binding of the...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

... activation domain duringevolution. Domains of mouse HSF3 were swapped with the corresponding domains of chicken HSF3, and the chimeras possessing the chicken HSF3 activationdomain induced the expression ... alanine-rich sequence and the DNA-binding domain is sufficient to cause the func-tional difference between the two orthologues [28]. Aschicken HSF1 can bind to the HSE, its amino-terminaldomain ... facilitate protein fold-ing and suppress protein aggregation, this response plays a major role in maintaining protein homeostasis. The heat shock response is regulatedmainly at the level of transcription...
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Báo cáo khoa học: Human mitochondrial transcription factor A possesses multiple subcellular targeting signals pptx

Báo cáo khoa học: Human mitochondrial transcription factor A possesses multiple subcellular targeting signals pptx

... weak, and both N-terminal and C-terminal flanking sequences enhance the nuclear targeting of EGFP. Finally, several mutations in the HMG1domain increased the mitochondrial targeting of the EGFP ... fusionproteins, implying involvement of these residues in nuclear targeting. Interestingly, mutations in threeinvariant residues (P66, W88, and K96) resulted in asignificant increase in the proportion ... its interactionwith p53 [18] and acetylation [19]. Another interestingpossibility is the regulation of the effects of TFAM byits subcellular targeting. In the mouse and chicken, butnot in the...
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Báo cáo khoa học:

Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"

... manuscript revision.JK was involved in the design and statistical analysis of the study. MS conceived and coordinated the study and was involved in the interpretation of the data and manuscript revi-sion. ... involved in drafting the manuscript.MG participated in analysis and interpretation of the data and in drafting the manuscript. PS, JS and MV contributed to the conception and design of the study and ... management.Competing interests The authors declare that they have no competing interests.Authors' contributionsMG, GC and EW participated in the collection and interpreta-tion of the data and were involved...
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Tài liệu Báo cáo khoa học: The cellulosomes from Clostridium cellulolyticum Identification of new components and synergies between complexes ppt

Tài liệu Báo cáo khoa học: The cellulosomes from Clostridium cellulolyticum Identification of new components and synergies between complexes ppt

... attributed to the physical prox-imity of the enzymes in the mini-cellulosomes and tocellulose targeting of the complexes via the CBM of the mini-scaffoldin [21]. The most active mini-cellulo-some ... genes were found to begathered in a large operon called the cip-cel cluster,beginning with the gene encoding the scaffolding pro-tein named cellulosome-integrating protein C (CipC),followed ... quantities in the other five fractions.All the proteins present in F5 were also present in F6. Among these, we detected protein 2 (Cel9P) [14] and proteins 5a (Cel9G) [25] and 5b (Cel9H) [28].Cel9P and...
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Tài liệu Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1 ppt

Tài liệu Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1 ppt

... a protein with covalently attachedflavin, synthesized only in bacteria grown in the presenceof nicotine The DNA carrying the sarcosine dehydrogenase-likeORF63, corresponding to a protein of ... occurrence and has been described in detail for different bacteria [31,33]. The similarity of the C-terminal domain of MABO to otherproteins of the sarcosine dehydrogen ase and oxidase familymay indicate ... This is in line with a decreased redoxpotential, as a similar inactivating effect upon b reaking the covalent cofactor-protein linkage has been observed withanother oxidase. Wh en breaking the...
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Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt

Tài liệu Báo cáo khoa học: The resident endoplasmic reticulum protein, BAP31, associates with c-actin and myosin B heavy chain Analysis by capillary liquid chromatography microelectrospray tandem MS ppt

... many other acetylated proteins, removal of the initiatormethionine residue and acetylation of the glutamic acidresidue is important in regulating the interaction betweenactin and myosin in the ... heterogeneousN-terminal peptide. Fig. 4A shows the tandem mass spec-trum of the N-terminal peptide as reported in the sequencedatabase: the N-terminal methionine residue has beenTable 1. Overview of the tandem ... cleavage.Materials and methodsPlasmids and cloningcDNA encoding human BAP31 with the Flag peptideepitope sequence inserted between the codons for aminoacids 242 and 243 was incorporated into the pcDNA3.1expression...
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