... electrons is used to pump protons from the mito-chondrial matrix towards the inner membrane space,thereby creating a proton gradient. The energy storedin the proton gradient is used to drive the ... Studies in isolated mitochondria showed that blockage of mitochondrial permeability transition pores by cyclosporin A affected neither DWm, ATP synthesis, nor respiration rate. The mitochondrial ... prevents opening of the MPTP, thereby leading to an increased DWm[17,20]. The CsA analog N-methyl-4-isoleucine-cyclos-porin (NIM811) is also known as an inhibitor of MPTP, and to lead to an increase...