Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
Báo cáo khoa học: Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation doc
... 2006 FEBS Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of b-oxidation Guilhem Larigauderie1,2,3, Clarisse Cuaz-Pe´rolin1,2,3, ... content of macrophages was increased by overexpression of adipophilin and ⁄ or loading with VLDL. In contrast, inhibition of adipo-philin expression using siRNA prevented lipid-droplet formation and ... and adipophilin- overexpressing cells. By itself, VLDL increased adipophilin expression, which explains the lack of effect of adipophilin overexpressionon cellular triglyceride content in macrophages...
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Báo cáo khoa học: Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro pptx
... baseline levels by 30–45 min, depending upon the dose. The increases in serum insulin, glucose and choline induced by choline weretime- and dose-dependent.Ó FEBS 2003 Choline increases serum insulin ... TurkeyIntraperitoneal injection of choline (30–90 mgÆkg)1)produced a dose-dependent increase in serum insulin, glu-cose and choline levels in rats. The increase in serum insulininduced by choline ... besignificant.ResultsEffect of choline on serum insulin, glucose and cholinelevelsFigure 1 illustrates the changes in serum insulin, glucose and choline levels, for a period of 60 min, following i.p.injection of choline...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) (also knownas heregulin) that binds to ERBB3 and ERBB4.NRG1 and NRG2 bind to ... domain; and aC-terminal regulatory domain [2]. The extracellulardomain is subdivided further into four domains. Thetyrosine kinase domain consists of an N-lobe and aC-lobe, and ATP binds ... 7p12-13 and codes for a 170kDa receptor tyrosine kinase. AllERBB proteins have four functional domains: anextracellular ligand-binding domain; a transmembranedomain; an intracellular tyrosine kinase...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf
... proteins. Thus, the MEN1 ⁄ LEDGF-interactingdomain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHDdomains, the FYRN domain, the transactivatingdomain, ... 2010)doi:10.1111/j.1742-4658.2010.07608.xThe increasing number of chromosomal rearrangements involving the human MLL gene, in combination with differences in clinical behavior and outcome for MLL-rearranged ... protein-binding platformfor several other proteins to initiate a fundamental cel-lular process. P-TEFb binds to the N-terminal portion of AF4, whereas the C-terminal portion of AF4 con-fers binding...
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Tài liệu Báo cáo khoa học: Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies pdf
... obtained to date indicate that inhibition of Ras activity suppresses cell proliferation and induces regression in a broad range of tumors.Intracellular antibodies, in particular single-chain ... tomisfold and represent specific substrates of the UPS. In fact, targeted inhibition of the 26S proteasome increases theformation of large perinuclear scFv aggresomes and inducesthe accumulation of ... fibroblasts (kindly provided by C.Schneider,CIB,Trieste,Italy),humantumorpancreaticcarcinoma Ger and MIA PaCa-2 (kindly provided by R. Orlandi, INT, Milan Italy) and human tumor breastadenocarcinoma...
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Báo cáo khoa học: DmGEN shows a flap endonuclease activity, cleaving the blocked-flap structure and model replication fork docx
... pro-gressing lagging strand. RF2, RF3 and RF4 are theforms of the normal replication fork differing in thegap sizes of the lagging strand. The gaps in the RF2,RF3 and RF4 are 8, 4 and 0 bp, ... representation of the conserved N and I domains of some members of the RAD2 ⁄ XPG family. The total number of amino acids in each protein and homology (% identity) between DmGEN and other members are indicated. ... residues (asterisks 2 and 3 in Fig. 2B) arehighly conserved in the I domain of the RAD2 ⁄ XPGfamily, and are important in coordinating divalentmetal ions to interact with an incoming nucleotide[21]....
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Báo cáo khoa học: Methylcitrate synthase from Aspergillus fumigatus Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia ppt
... wild-type strain was investigated in liquid cultures. The inhibitory effect of propionate in combination with glucose was tested by use of 50 mm glucose as main carbon source and addition of different ... explained by the accumulation of propionyl-CoA from amino aciddegradation (valine, isoleucine and methionine) at con-ditions of carbon starvation. In contrast, inhibition of naphtopyrone synthesis ... wasproduced and sequenced (Accession No. AJ888885).Comparison of genomic and cDNA revealed twointrons with a size of 58 and 64 bp. Removal of theintrons led to an open reading frame of 465 aminoacids...
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Báo cáo khoa học: Interflavin electron transfer in human cytochrome P450 reductase is enhanced by coenzyme binding docx
... reticulum, and three folded domains: an FAD- and NADPH-bindingdomain related to ferredoxin-NADP+reductase, a flavo-doxin-like FMN-binding domain and a connecting ÔlinkerÕdomain. In addition ... reduc-tion in rate of interflavin electron transfer in NADH-reduced CPR thus suggests a role for coenzyme binding, and in particular for interactions made by the 2¢-phosphate of NADPH, in modulating interdomain ... inter-actions involving its adenine end, whose binding site iscontained within the FAD-binding domain of the protein(Fig. 2). The electron density for the NMN portion of thecoenzyme is poorly defined, and...
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Báo cáo khoa học: Probing protein–chromophore interactions in Cph1 phytochrome by mutagenesis potx
... positioning of the imidazole side chain of H260#381adjacent and hydrogen-bonded to the ring C nitrogen in 1ZTU; (b) the role of B ⁄ C ring nitrogen protona-tion in electronic coupling [36]; and ... His6-tagged apoproteins in E. coli, purified and tested for PCB-binding, apopro-tein folding, Pr–Pfr photochromicity and thermalreversion using SDS ⁄ PAGE ⁄ zinc fluorescence and CD and UV-Vis spectroscopy. ... attachment site interacts with the propionate sidechain of chromophore ring B [18,19]. Additionally, thestrength and position of the dominant red and far-redabsorbance bands of Pr and Pfr, respectively,...
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Báo cáo khoa học: "Modelling Semantic Role Plausibility in Human Sentence Processing" pot
... our model by verifying that it in- deed correctly predicts human judgements, and by comparing its performance with that of a standardrole labeller in terms of both judgement prediction and role ... com-binations of verbs and arguments are still mostlyunseen in training for all data sets.We describe two complementary approachesto smoothing sparse training data. One, Good-Turing smoothing, ... similar meanings together into frames (i.e.descriptions of situations) with a set of frame-specific roles for participants and items involved(e.g. a killer, instrument and victim in the Killingframe)....
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