Báo cáo khoa học: Characterization of mutations in crucial residues around the Qo binding site of the cytochrome bc1 complex from Paracoccus denitrificans pdf
Báo cáo khoa học: Characterization of mutations in crucial residues around the Qo binding site of the cytochrome bc1 complex from Paracoccus denitrificans pdf
... monitoring of the protonation state of several crucial residues in the presence and absence of stigmatellin. Interestingly, several residues perturb the orientation of the quinone binding site ... 2008)doi:10.1111/j.1742-4658.2008.06611.x The protonation state of residues around the Qo binding site of the cyto-chrome bc1 complex from Paracoccus denitrificans and their interactionwith bound quinone(s) was studied by a combined ... bc1complexes from other organisms. The mutated residues are highlighted in Fig. 1.Results Site- directed mutations in the Qo binding site Mutations in conserved positions of cytochrome b at the Qosite...
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Báo cáo khoa học: Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models pptx
... likely that the binding of subunit 3is a necessary prerequisite for the binding of critical,nuclear-encoded subunits that stabilize the growing com-plex. Thus, while the binding of subunit ... to that of the bovine enzyme, the structure of the bovine oxidase can be used to predict some of the conse-quences of the human mutations. Most of the mutations discussed below occur in residues ... methods). The effect of the mutations on oxygen consumption, proton-pumping activity, and on the binding of subunit 3 wereexamined.W249Stop and DF94–F98 in subunit 3 alter the assembly of cytochrome...
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Báo cáo khoa học: "Hedge classification in biomedical texts with a weakly supervised selection of keywords" doc
... patternmatching and manual supervision procedure. Withthese seed sets they then performed the followingiterative method to enlarge the initial training sets,adding examples to both classes from an ... irrelevantkeywords in the majority of cases.2.3 Feature (or keyword) selectionTo handle the inherent noise in the training datasetthat originates from its weakly supervised construc-tion, we applied the ... usages of otherwise commonhedge cues is a promising solution for addressing the false positives in hedge classifiers and for improving the portability of hedge modules.4.1 Resolving the scope of...
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Báo cáo khoa học: "Veterinary decision making in relation to metritis - a qualitative approach to understand the background for variation and bias in veterinary medical records"
... influ-ential interaction between the interviewer and the inter-viewed during the interviews that could influence the statements of the interviewed e.g., the use of leading ques-tions. In the phase of ... advisorsThese are veterinarians who primarily followed their owndefinitions of different scoring values, such as excludingcertain scores (see examples in table 1). They find the def-initions incorrect. ... [3]. No official treatment threshold waslinked to the metritis scale, but leading Danish veterinari-ans in the field recommend using a grade of 5 on the scaleas a cut-off value for initiating...
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Báo cáo khoa học: Mitochondrial calcium signalling in cell death Delivered on 1 July 2004 at the 29th FEBS Congress in Warsaw pptx
... proteindeveloped for measuring [Ca2+] within the mitochond-rial matrix and was instrumental in gaining new insightinto mitochondrial Ca2+handling, i.e. the topic of thisreview [13]. In the ... aequorin moietyincluding an HA1 tag was fused in frame with the N-terminal portion (including the 25 amino acidscleavable presequence and the first eight amino acids of the mature polypeptide) of ... that of aequorin. Aequorin is a Ca2+-sensitivephotoprotein of the jellyfish Aequorea victoria, whichemits light upon binding of Ca2+to three high-affinitysites present in the protein sequence....
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Báo cáo khóa học: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations pptx
... readilydetected in association with PS1 complex in embryonictissue as indicated by reactivity of NCT ectodomainantibody. NCT was barely detectable in the PS complex from adult mouse brain as shown in the ... shown by others [5,17]. The complex was stable in 0.5% DDM even after addition of reducing agent (1%b-mercaptoethanol), indicating strong interaction, inde-pendent of maintenance of disulfide ... characteristics of the PS complex will facilitateelaboration of the molecular processes involved in the production of Ab. Analysis of these complexes requiresdetergent solubilization in conditions...
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Tài liệu Báo cáo khoa học: Characterization of 1H NMR detectable mobile lipids in cells from human adenocarcinomas doc
... Fig. 1B (insert), whichshows the characteristic cross peak from the geminalprotons of carbons 1 and 3 of glycerol in TG [1].Cross peaks of lipids, including the T signal, wereabsent in cells ... compared in samplesobtained by cells harvested at different days from the same seeding. In the following, ML quantification derives from intensity measurements of the peak at 1.28 p.p.m. in 1D spectra ... phosphatidylcholine synthesis is reduced or in the presence of phosphatidylcholine degradation[18,25]. In particular, inhibition of the final step of phosphatidylcholine synthesis via the Kennedy path-way may...
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Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
... wasbased on the conserved amino acid sequences of the catalytic domain of members of the GH18 familyresulted in the amplification of an expected 147 bpsequence. Cloning and sequencing of this fragmentrevealed ... of the soleGlyco_18 domain, the C-terminal tail of C. gigas CLPsmay not noticeably contribute to the structure and the function of these proteins. Interestingly, Cg-Clp1 andCg-Clp2 C-terminal ... togetherchitinases and proteins devoid of catalytic activity dueto the substitution of a critical amino acid in the cata-lytic centre. This latter singular class of proteins, calledchitinase-like...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... related proteins, as shown in Fig. 1B. Toevaluate whether the Sp1 -binding site in the DNASE1distal promoter is crucial for expression, a mutated binding site was introduced into the )197H construct,resulting ... of alternative promoters in DNASE1 results in no generation of protein isoforms. The 5¢-UTR of eukaryotic mRNA in uences the initi-ation step of protein synthesis and thereby in partdetermines ... Sp1binds to the putative site in the region from )90 to)51 relative to the transcription start site of exon 1a.Because the Sp1 -binding site might be recognized byother members of the Sp1 transcription...
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Tài liệu Báo cáo khóa học: Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae pptx
... Glutamine was effective in protecting the enzyme from inactivation and its effect wasagain dose-dependent, suggesting that inhibition by DONoccurs at the active site or the glutamine -binding site ... of the genes. In SNO1, the 199th G from the 5¢ terminus of the open readingframe was deleted to result in a frame-shift and appearance of stop codons in the downstream. As a result, a protein ... 4). These experimentsconsistently pointed to the formation of glutamate, provingunambiguously that the complex did indeed hydrolyzeglutamine efficiently.Kinetics of the glutaminase reactionThe...
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