Báo cáo khoa học: Metabonomics in pharmaceutical R & D doc

... under way to investigatethe reporting needs and standardization of reportingarrangements for metabonomics studies. The StandardMetabolic Reporting Structures group (http://www.smrsgroup.org) ... lower left quad-rant and in the corresponding loadings plot, this region indicatedthat NMR peaks from 2-AA (2-aminoadipate) were important, andthus this is a biomarker of the hydrazine-induced ... being devel-oped to deﬁne standards in a number of areas relevantto metabonomics, including characterization of sam-ple-related metadata, technical standards and relateddata, metadata and...

Báo cáo khoa học: "Sparsity in Dependency Grammar Induction" doc

... paper we presented a new method for unsu-pervised learning of dependency parsers. In con-trast to previous approaches that constrain modelparameters, we constrain model posteriors. Ourapproach ... outperforms the standardEM algorithm and a discounting Dirichlet prior.We have several ideas for further improving ourconstraints, such as: taking into account the direc-tionality of the edges, ... Green indicates correct dependencies and redindicates incorrect dependencies. The numbers on the edgesare the values of the posterior probabilities.though the average increase is only 1.5%. PR-Sis...

Báo cáo khoa học: acids in the brain: D-serine in neurotransmission and neurodegeneration ppt

... cysteine and thrionine transporter. D- Serine Selected referencesOccurrence Enriched in the mammalian brain and in some insects [24,30]Target receptor NMDAR [10,22,93]Actions Modulates NMDAR transmission, ... MK-801NMDA +DNQDsdAFig. 2. The role of endogenous D- serine in NMDAR-elicited neurotoxicity. The removalof D- serine by D- serine deaminase enzyme(DsdA) completely prevented NMDA-elicitedcell death. ... Vesicular and nonvesicular release modes described in neurons and astrocytes [25,50,65,99,100] D- serFig. 3. D- Serine localizes to neurons andastrocytes in the brain. Staining for D- serinewas performed...

Tài liệu Báo cáo khoa học: Changes in purine speciﬁcity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx

... All residue swapping procedures thereforeinvolved the GAF B regions. We hoped to prototypi-cally identify individual residues or narrow regions in the cyaB1 and rPDE2 tandem GAF domains that dis-criminate ... mPDE2 GAF domain crystal structure[12]. Of the 12 amino acids identiﬁed as interactionpartners for cGMP, only four bind directly to the pur-ine moiety and are thus potentially involved in deﬁningpurine ... [12]. In analogy, in PDE5GAF A, a F205A mutation (Phe433 in rPDE2) abro-gated cGMP binding [13], and, in PDE6, both of theamino acids corresponding to Phe433 ⁄ Asp434 in rPDE2A are required for...

Tài liệu Báo cáo khóa học: Mutations in the hydrophobic core and in the protein–RNA interface affect the packing and stability of icosahedral viruses doc

... Kremer, W.,Maurer, T., Doker, R. & Kalbitzer, H .R. (2000) Pressure-inducedlocal unfolding of the Ras binding domain of RalGDS. Nat.Struct. Biol. 7, 547–550.50. Suarez, M.C., Lehrer, S.S. & ... ofchange induced by pressure.Changes in secondary structure upon dissociationand denaturationTo further conﬁrm the urea-induced changes in secondarystructure, we analyzed the UV CD spectra of ... particles were treated with a high concen-tration of urea. In contrast, the phage titer recovered afterhigh-pressure treatment. Thus, after pressure-induced dis-sociation of the virus, information...

Tài liệu Báo cáo khoa học: "Experiments in Semantic Classification" pptx

... operation act performance performance action act deed operation performance action act deed deed act deed doing act action deed act action deed instrument act proceeding act proceeding action ... thesaurus is then considered; this involves a method for defining the meanings or uses of words, and a procedure for classifying them. It is suggested that word uses may be defined in terms ... proceeding, acting, work, working'. Their sets of rows ranged from 19 for 'acting' through 48 for 'business' and 49 for 'operation' to 90 for 'work'. 325...

Tài liệu Báo cáo khoa học: Histones in functional diversification Core histone variants pdf

... fold regions needed for thehandshake contacts is essential. Their N-termini arerequired for interaction with neighbouring DNAwhile the C-termini provide docking domains forinternucleosomal interactions. ... example, duringradiation-induced DNA damage or other events lead-ing to double stranded breaks (DSBs) in DNA, a his-tone variant present at the DNA damage point mayact as a marker for the quick recruitment ... are already deposited on the DNA dur-ing cell-cycle replication. There may be two possibilit-ies. Either for immediate chromatin repair duringtranscription or to provide a remedial measure...

Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc

... mM2,4-dinitrophenolhydrazine in 2MHCl, incu-bated at room temperature and neutralized. The derivatizedproteins were separated by SDS/PAGE, transferred to anitrocellulose membrane and treated as previous ... ﬁxed by immersion in 2% paraformaldehyde/0.2% glutaraldehyde in NaCl/Pifor 2 h at room tempera-ture, contrasted with 1% uranyl acetate. The resultingmaterial was dehydrated and embedded in ... Mitochondria are in fact a majorintracellular source of ROS during oxidative phosphoryla-tion and the increased production of ROS is implicated in the aging process [12–16]. Mitochondria are also...

Tài liệu Báo cáo khoa học: " Multimodal In-Car Dialogue" docx

... system, developed in the TALKproject in cooperation between several academicand industrial partners, employs the InformationState Update paradigm, extended to model collab-orative problem solving, ... and a set of XSLT trans-formations to yield the output strings. Output in German and English is produced by accessing dif-ferent dictionaries in a uniform way. In order to facilitate incremental ... so-called system controlled dialogues where the useris restricted to choosing their input from providedmenu-like lists and answering speciﬁc questions.The user never is in control of the dialogue....

Tài liệu Báo cáo khoa học: "Coherence in Spoken Discourse*" pptx

... would never be found in a writ- ten text. extended in order to maintain a coherent discourse structure for the modelling of the producer. Thus rhetorical relations describing planning processes ... combined D[ ROM, I newly generated sentence is incorporated in the cur- rent discourse structure. Although the production took place under a cer- tain amount of pressure, the right frontier ... speaker to return to the branching node of the discourse structure where the digression was introduced. 4 Discourse grammar 4.1 Tree descriptions A definition of TDG is given by Kallmeyer (1996)...

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