Báo cáo khoa học: N-Glycans of the porcine nematode parasite Ascaris suum are modiﬁed with phosphorylcholine and core fucose residues pot

... ª 2006 FEBS N-Glycans of the porcine nematode parasite Ascaris suum are modiﬁed with phosphorylcholine and core fucose residues Gerald Po¨ltl, Denise Kerner, Katharina Paschinger and Iain B. ... PC -modiﬁed glycans, the core fucose is a1,6-linked as in mammals. Other N-glycans fromnematodes also carry a1,3 -fucose on the proximal[21,26] and, uniquely, distal GlcNAc residues of the core ... [24] and O. volvulus[25]. These N-glycans contain the typical trimannosyl core, with and without core fucosylation, and carrybetween one and four additional N-acetylglucosamine residues. In these...

Báo cáo khoa học: " Effect of the medical emergency team on long-term mortality following major surgery"

... about the force with which the victims were hit and swept away by the wave.Antiinfective therapyOur intial choice of anti-infective therapy was a combination of a potent quinolone combined with ... suffered at least loss of one rel-ative, for example, a partner or child, and two mothers of ourcohort lost both of their children. The majority of patients com-plained of nightmares, emotional detachment, ... includingamputation, and frequent wound dressing changes. Theseprocedures are conceptually simple and common standard[18]. In the interim between surgery and secondary closure, with or without skin...

Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt

... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy-ses of SERCA were performed with the data obtained in the pres-ence of (A) ... on the mica surface without being broken, resulting in‘double membranes’, and these ﬂatten on the mica sur-face with a thickness of  10 nm. Unfortunately, the smallness of the vesicles and their ... conformation), and the number of peaks must correspond to the velocity of the catalytic cycle of SERCA. Interestingly, the turnover rate, ATP concentration dependency and TGinhibition of up–down motion are...

Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... colonizes the surface area of the gastric mucosa in the human stomach and is one of the most adapted microbial pathogens.  50% of the world’s population carries this bacterium, causingchronic, often ... infection [30]. These data were alsosupported by several other research groups [15].However, the role of CagA with respect to inducing the loss of cell polarity is much clearer. The kinasePar1b ... other members of this kinase family (includingPar1a, Par1c and Par1d), and that these interactionscontribute to the H. pylori-induced elongation pheno-type of AGS cells. Taken together, these...

Tài liệu Báo cáo khoa học: Upregulation of the a-secretase ADAM10 – risk or reason for hope? docx

... bothmutations are rare (segregation in seven AD familiesout of 1004) and are only partially penetrant, theseresults give support to the hypothesis that the humangene for ADAM10 plays a role in the aetiology ... point of intervention within the biosyntheticpathway of ADAM10 is provided by directly interfer-ing with the expression of the gene for ADAM10: the promoter region of the gene for ADAM10 has ... Epac and the small GTPase Rac [111,112]. This recently led tosynthesis and evaluation of novel 5-HT4-agonists; two of them increased APPs-a production in the cortex and hippocampus of mice and...

Tài liệu Báo cáo khoa học: Myristoylation of the dual-speciﬁcity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf

... activity in the absence of myristoylation, the subcellular localization of the enzyme was altered.Compared with the wild type, the ability of nonmyristoylated JSP1 toinduce JNK activation and phosphorylation ... of the transcription factorc-JUN was attenuated. Upon expression of wild-type JSP1, a subpopula-tion of cells, with the highest levels of the phosphatase, was induced toﬂoat off the dish and ... dephosphorylate the Tyr and Thr residues in the activation loop of MAPKs and thereby attenuate signaling [17,19]. In addition, there isa group of low molecular mass DSPs that lack the regu-latory...

Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc

... In accordance with the fundamentalrole of HSF1 in the heat shock response, the require-ment of HSF1 and HSF4 in development of the lens and olfactory epithelium is limited to the postnatalperiod, ... knockout of Hsf1 and Hsf4, the abnormal levels of FGF-7 returned to normal, and proliferation and differentiation of the epithelial cellswere stabilized. These ﬁndings indicate that HSF1 and HSF4 ... lens development, the trimeric form of HSF4 increases, while the levels of HSF1 and HSF2 are reduced [102]. In the olfactoryepithelium of 3–6-week-old mice, the expression proﬁle of HSF1 remains...

Tài liệu Báo cáo khoa học: Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR docx

... to eachother, are superimposed with root mean square devia-tions of 1.3 A˚for the backbone of the b-strands and 1.7 A˚if the loop regions are included, indicating thatall of these family ... thatseparately encoded the N-terminal half (residues 1–153) and the C-terminal half (residues 151–299) of At3g16450.1, and these were used to prepare15N-labeled samples of each domain. The 1H-15N ... rootmean square deviation values for the N- and C-terminaldomains versus the agglutinin are 2.2 and 2.0A˚, respec-tively. Thus each of the two domains of At3g16450.1adopts a lectin fold. The orientation...

Tài liệu Báo cáo khoa học: Switching of the homooligomeric ATP-binding cassette transport complex MDL1 from post-translational mitochondrial import to endoplasmic reticulum insertion pptx

... inter-acts with the TOM receptor, responsible for the trans-location of the preproteins to the translocase of the inner mitochondrial membrane (TIM)23 complexlocated in the IMM. The presequence ... associated with TIM23 and completes the translocation of the preprotein into the matrix. There the presequence is removed by the mito-chondrial processing peptidase. Subsequently, IMMproteins are ... ATPvalues of 120 lm and 200 lm and kcatvalues of 74 ATPÆmin)1 and 77 ATPÆmin)1(per MDL1 subunit),respectively. The ATPase activity of the transportcomplex is in very good agreement with data of...

Tài liệu Báo cáo khoa học: Analysis of the molecular dynamics of medaka nuage proteins by ﬂuorescence correlation spectroscopy and ﬂuorescence recovery after photobleaching doc

... movement in the granules and diffused in the cytosol of HeLa cells, just as in the medaka embryo. The other twogene products, Nanos and Tudor of the medaka, which are known as con-stituents of the ... mea-sure the mobility of the components in the PGCs. The medaka embryo was peeled off the chorion, and the segment containing the part of PGCs was excised forobservation by microscopy and FCS ... outside of the nuage in the cytoplasm of the migrating PGC. FCS analysis revealed that Olvas–GFP diffused with a diffusion constant of 7.0 lm2Æs)1(Fig. 3A). During the measurement of the PGC, the olvas3'UTRGFP/RFP...

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