Báo cáo khoa học: The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in nonpolarized mammalian cells potx
Báo cáo khoa học: The intrinsic structure of glucose transporter isoforms Glut1 and Glut3 regulates their differential distribution to detergent-resistant membrane domains in nonpolarized mammalian cells potx
... replacement of neither the C-terminal nor the N-terminal amino acids of Glut1 domains with the corresponding amino acids of Glut3 had any significant effect on the distribution of Glut1 in CHO-K1 cells ... between Glut1 and Glut3 are the N-terminus and the C-terminus, and the large intracellular loop between transmembrane domains 6 and 7. As a unique sorting signal for the recruitment of Glut3 to the ... baso-lateral-sorting Glut1 to the apical cell surface in MDCK cells [24]. Recently, two proteins binding to the C-terminus of Glut1 have been reported. One is the Glut1 transporter- binding protein Glut1CBP,which...
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Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... mechanism is still incomplete. In light of the reported ACMSD upregulation in the liver of streptozotocin-induced diabetic rats and the suppres-sion of such elevation following insulin injection[21,22], ... homeostasis. Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the final fate of the amino acid, i.e. transformation into PA, com-plete oxidation through the ... representation of the overall structure of hACMSD. The (a ⁄ b)8barrel domain is colored in light blue and the ACMSD-specific small insertion domain in blue. The DHAP molecule and the protein residues involved...
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Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... an important role in building the Greek key structure and in designing the metal binding site and the active cavity of the system. The analysis of the H-bonds in the present structure has been ... assigned by the analysis of the H NHB experiment. In each subunit the metal ions were included by allowing copper t o bind to Ne2 of His48 and His120 and to Nd 1of His46, and zinc to Nd1 of His63, ... wever the He2 of His43 do exchange in D2Oindicating solvent exposure of such H-bond. H-bondsinvolving ring hydrogens of His43 are important in linking the loop III to the b barrel and the active...
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Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... protein stain-ing. The ratio of the upper protein band to the lower one wasestimated to be approximately 2 by densitometric scanning.Activity staining of the enzyme indicated that the upper bandreconstituted ... aD in the N-terminal and by three than bD in the C-terminal,respectively. In the final structure, all residues of the a chain(Met1–Glu555), all but N-terminal 10 residues of the bchain (Phe11–Glu194), ... propane-1,2-diol and essential cofactor K+are bound inside the (b/a)8barrel above the corrin ring of cobalamin. K+is hepta-coordinated by the two hydroxyls of the substrate and fiveoxygen atoms from the...
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Báo cáo khoa học: The crystal structure of NlpI A prokaryotic tetratricopeptide repeat protein with a globular fold potx
... FEBS the full-length HOP, they act to facilitate the assembly of multichaperone regulatory complexes. The struc-tural independence of these TPR domains, and the presence of independent ligand-binding ... that they are discrete domains. TPR domains, or even subsets of TPRswithin a domain [12], are often studied independently. In the course of a wider effort toward understandingTPR structure and ... organism. The structure reveals an intimate association between the TPR motifs and the rest of the protein, showing how the TPR par-ticipates in the overall fold. Until now, many of the TPR-containing...
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Báo cáo khoa học: The oxidative effect of bacterial lipopolysaccharide on native and cross-linked human hemoglobin as a function of the structure of the lipopolysaccharide A comparison of the effects of smooth and rough lipopolysaccharide ppt
... changes in the purified lipid A and in the lipid Amoiety of intact LPS were reported [4]. The binding of LPS to oxyHb results in the oxidation of theHbtometHbandhemichrome[3].Incontrasttothelack of ... cross-linked hemoglobin, both smooth LPSs produced arate of oxidation faster than the corresponding rough LPSs,indicating the importance of the binding of LPS to the hemoglobin. The effect of the ... in the presence and absence of EDTA (Fig. 1). The rate of oxidation wasincreased in the presence of the LPSs of both the smooth and rough E. coli, but the rate of oxidation in the presenceof...
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Báo cáo khoa học: The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster Implications for cellulose synthase complex formation and oxidative stress response potx
... clear that the plant protein is not able to bind metal cations in the conformation found in the crystal structure. Neither the firstnor the other domains are able to coordinate cations in theseregions, ... side. In the case of Anx24(Ca32), a number of hydrophobic and aromatic residues are found on the surface of the mem-brane-binding side. When comparing the membrane- bind-ing loops of Anx24(Ca32) and ... Acomparison of the membrane binding loops with AnxA5 and Anx24(Ca32) reveals that canonical calcium binding in the loops of domain I might be possible in Anx(Gh1), in contrast to the bell pepper annexin....
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Báo cáo khoa học: X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside pdf
... following the first helices of domains 1 and 2, respectively. The EF-hand-like calcium site of domain 2 was describedearlier, and tight binding of the ion was shown to con-tribute to the integrity of ... but rather to that of the larger maltose-bind-ing protein. This kind of protein is exemplified by the Thermus thermophilus protein, PDB entry 2B3B [28]. The mode of binding the monosaccharide ... binding proteins are abundant in bacteria by virtue of their essential roles as high-affinity receptors in ABC transport systems and chemotaxis. One of the best studied of these receptors is the...
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Báo cáo khoa học: The crystal structure of a xyloglucan-specific endo-b-1,4glucanase from Geotrichum sp. M128 xyloglucanase reveals a key amino acid residue for substrate specificity potx
... end of the active site cleft, which accounts for its exo mode of action. In contrast, XEG lacks a corresponding loop at this site, thereby allowingbinding to the middle of the main chain of the ... corresponding to the exo-loop of OXG-RCBH. The coordinates and structure factorshave been deposited in the Protein Data Bank (PDB)(accession code 3A0F). The structure of XEG was compared with those of other ... RMSD of 1.07 A˚by the corresponding 683 Ca atoms among 756 residues, indi-cating close similarities between their domain structuresas well as the relative positions of the two domains. The...
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Báo cáo khoa học: The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1) pdf
... in host responseevents, including the participation of host CypA in binding the capsid protein Gag of HIV-1 during infec-tion in humans and packaging into HIV virions, and the association of ... partners: PPIL1 binds to the SNW domain-containing protein 1 (SKIP), and CypHbinds to the small ribonucleoprotein Prp4 [18,31–33].Interestingly, in both of these cases, the interactionwith ... coordinating the backbone oxygen of Lys488 of the QAEGPKRpeptide (Fig. 3A), and Phe540 is coordinating Lys488through a stacking interaction. The other interactionsbetween the side-chain of the...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngchuyên đề điện xoay chiều theo dạngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật