Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc

Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc

Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc

... speci- fic roles of the various members of the DIM family, e.g. DIM A and DIM B, in these functions have never been investigated. The recent developments in our understanding of the biosynthetic ... between the number of CFUs of the wild-type strain and that of the PMM56 mutant strain in lungs and in the spleen (Fig. 7A). Indeed, both strains multi...
Ngày tải lên : 23/03/2014, 09:20
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Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

Tài liệu Báo cáo khoa học: Functional dissection of the Schizosaccharomyces pombe Holliday junction resolvase Ydc2: in vivo role in mitochondrial DNA maintenance pptx

... base-pairs in the centre of the junctions [19]. Detailed understanding of the functional role of these interactions would require the crystal structure of the Ydc2–junction complex. In this study the ... [14,20]. Binding of CCE1 results in the complete unpairing of the four base-pairs in the centre of the junctions with a lesser disruption of the...
Ngày tải lên : 20/02/2014, 11:20
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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx

Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx

... least for the Fig. 2. Schematic view of the parallel between Pin1 and CKS in protein degrada- tion. Top: Model of the SCF CDC4 E3 ligase and the role of Pin1. Pin1 is brought in with the cyclin E ... similar binding pockets of Pin1 and FKBP and the structural resem- blance between their respective high-affinity inhibitors [28] further underscore the si...
Ngày tải lên : 07/03/2014, 05:20
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Báo cáo khoa học: Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis Functional analysis of the promoter identifies a calcium sensitive region required for basal activity doc

Báo cáo khoa học: Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis Functional analysis of the promoter identifies a calcium sensitive region required for basal activity doc

... were subcloned into pBSSK (Stratagene). The structure of the gene including the 5¢ and 3¢ flanking regions was determined by double-stranded DNA sequencing, exons were identified according to the sequence of ... sites within the MGP coding sequence (Fig. 2 ). Analysis of the phase of each of the xMGP introns located within the coding region revealed that introns 2 a...
Ngày tải lên : 08/03/2014, 10:20
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Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

... structures of the wild-type, single- and double-mutant EhPGKs in a closed conformation will certainly help to clarify the molecular arrangement in the guanine ring binding site during the binding of ... B); and Val339, Gly340 and Val341 (patch C). The corresponding reported amino acid residues involved in adenine binding in the other crystallized proteins, as w...
Ngày tải lên : 16/03/2014, 01:20
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Báo cáo khoa học: Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation pdf

Báo cáo khoa học: Molecular dynamics of the DNA-binding domain of the papillomavirus E2 transcriptional regulator uncover differential properties for DNA target accommodation pdf

... gain insights into the structural dynamics of the DNA-binding domains of two prototypic strains, human papillomavirus strain 16 and the bovine papillomavirus strain 1. The simulations underline ... to alanine of the residues Lys325 and Lys327, located in the b2–b3 loop, produce a decrease in the DNA bind- ing [22] that is restored upon back mutation into arginine,...
Ngày tải lên : 16/03/2014, 10:20
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Báo cáo khoa học: Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae pot

Báo cáo khoa học: Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae pot

... B (transactivation domain), C (DNA-binding domain), D (hinge region) and E ⁄ F (ligand- or hormone-binding domain) [8,9]. The X-ray crystal structures of the ligand-binding domains of EcR, USPs and RXRs have been ... specific binding of LaEcR-A was not increased in the presence of LaRXR. These results are in contrast to the insect receptors where the specific binding...
Ngày tải lên : 30/03/2014, 04:20
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Báo cáo khoa học: Molecular analysis of the interaction between cardosin A and phospholipase Da Identification of RGD/KGE sequences as binding motifs for C2 domains pdf

Báo cáo khoa học: Molecular analysis of the interaction between cardosin A and phospholipase Da Identification of RGD/KGE sequences as binding motifs for C2 domains pdf

... [12,14,15,19,20,22], there are no reports on the true nature of the RGD- containing proteins and their interacting partners. The involvement of the PLDa C2 domain in these Fig. 7. C2 domain is degraded by cardosin ... at the tip of a loop protruding away from the core of the protein. This amino-acid motif mimics RGD in terms of charge and is positioned at th...
Ngày tải lên : 30/03/2014, 11:20
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Báo cáo khoa học: Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition pptx

Báo cáo khoa học: Structural flexibility of the methanogenic-type seryl-tRNA synthetase active site and its implication for specific substrate recognition pptx

... linked, and incorrect binding of ATP can affect serine binding and vice versa [22]. Asn435, together with Asp416 and Glu432, contributes to binding of the Mg 2+ ion between the a- and b-phosphates of ... r.m.s.d of C a atoms after superposition of the catalytic domains in complex with different substrates and the cata- lytic domain of the apo-enzyme. The...
Ngày tải lên : 16/03/2014, 06:20
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Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt

Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt

... strains revealed the presence of a single point mutation in 1337 nucleotides of BmIVD. In the sku mutant, the 1127th guanine from the start codon was substituted by thymine and none of the other sites ... acts in the third step of leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, this mutant may be useful in the...
Ngày tải lên : 18/02/2014, 04:20
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