... destabili-zation of the overall structure of the sHsp [35,36].Therefore, we analyzed the effect of point mutations in the linker connecting the b5 and b7 strands of HSP22 on its thermal stability. The ... interaction of the sHsp with different unfolded target proteins [17,40].Therefore, it is desirable to analyze the effect of K137E and K137,141E mutations on the chaperone-like activity of HSP22. The ... on a comparison of the primary structure of different sHsp, predictions of their secondary structure and on superposition of the mammalian protein sequence on the 3D structure of already crystallized...