... Asn73 of BMP -6 in the wrist epitope is
crucial for recognition by the activin receptor type I. In the absence of the
carbohydrate moiety, activin receptor type I- mediated signaling of BMP -6
is totally ... totally diminished. Thus, flexibility within the binding epitope of BMP -6
and an unusual recognition motif, i. e. an N-glycosylation motif, possibl...
... in that they do not
appear to contain a signal sequence or pro-sequences
[6 8].
Surprisingly, the amino acid composition of proteins
purified from Atlantic snailfish skin tissue is quite sim-
ilar ... snailfish contradicts the
A
B
C
D
Fig. 4. Distribution of type I AFP mRNA in skin and liver tissues
from Atlantic and dusky snailfish. (A) Northern blot analysis of skin
tissue RNA...
... organism to adapt to its fluctuating nutri-
tional status or to varying environmental conditions.
However, the identification of the key factors of mito-
chondrial biogenesis in the context of proliferating
cells ... oxygen consumption following the
inhibition of ERRa confirmed the effect of this factor
on the mitochondrial respiratory chain. Inhibition of
both members...
... of con-
ventional mononuclear cis-diamminedichloroplatinum(II) (cisplatin). These
examinations took into account the fact that the local conformation of the
DNA at the sites of the contacts of ... this
additional protection in the duplex 1,4-IEC in the
5¢)5¢ direction is more extensive (Fig. 6) . The latter
additional protection is observed for two sites on the...
... G
(1991) The purification of tissue inhibitor of metallo-
proteinases-2 from its 72 kDa progelatinase complex.
Demonstration of the biochemical similarities of tissue
inhibitor of metalloproteinases-2 ... know the
role of individual MMPs, their expression pattern and
activation mechanisms. The best-described activation
mechanism for MMP-2 is the two-step cell-surface
ac...
... mediated via two distinct sig-
naling pathways. The first is enhanced Ca
2+
mobilization by the inositol
1,4,5-trisphosphate receptors due to inhibition of protein kinase A. The
second pathway concerns ... PI3-Kc
specific inhibitor, AS252424, antagonized the P2Y
12
-
dependent part of the Ca
2+
response, indicating that
PI3-Kß is the main isoform in Ca
2+
signal modulati...
... CPY -binding sites participates in
regulation of the specific binding of I
C
to the anionic
phospholipid membranes (Fig. 4A). The participation
of the N-terminal region of bovine PEBP in its mem-
brane ... mutational studies on the membrane
binding of I
C
and the disposition of the I
C
residues that
are positively charged and make up the CPY -binding
s...
... least
in part through inhibition of the NFjB signaling pathway. In addition,
in vivo, LXR agonists reduced TF expression within aortic lesions in an
atherosclerosis mouse model as well as in kidney ... prevent
functional activation of NFjB. Several models might
explain the inhibitory effect of LXR agonists on func-
tional NFjB activity. It is known that transcriptional
activatio...
... replication mechanism
of the hepatitis C virus (HCV), we have studied the role of sequences at
the 3¢-end of HCV minus-strand RNA in the initiation of synthesis of the
viral genome by viral RNA -dependent ... though it is about 25%
that of the wild -type (–)IRES. However in the latter
case the synthesis is less processive as a pause is
observed in about hal...
... in the crucial
position in ( 26) , unrelated to the positional condi-
tion DP~r9 on the argument of the predicate itself,
to define the distinguished position of the predicate
argument of the ... like (15)
are still allowed Coecause of the non-identity noted in
the discussion of (18) between the distinguished posi-
tion of arguments of functions and...