Báo cáo khoa học: Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli pdf
Báo cáo khoa học: Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli pdf
... molybdate to molybdopterin generates the molybdenum cofactor, which can be inserteddirectly into molybdoenzymes binding the molybdopterin form of the molybdenum cofactor, or is further modified in bacteria ... mixture did not result in theirinsertion into MPT (data not shown). In addition, wetested the insertion of metal ions into MPT-containinghSO. None of the metals was inserted into hSO(Fig. 3B), ... the biosynthesis of Moco in bacteria [22]. In addition to copper, various metals are known to bind tightly to sulfur-rich sites, leading to the question of whether other metal ions can bind to...
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Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... cycles in such a combinationdo not touch each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence ... rise to a negative in the characteristic equation(a positive autoinfluence). The absolute magnitude of acombined autoinfluence path is the product of all the ratesdivided by the product of all the ... cause instability. Then only the negative autoinflu-ence path of Eqn (16) remains, which then cancels the positive autoinfluence of Eqn (17). Revolving around the cycle then does not lead to an increase...
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Tài liệu Báo cáo khoa học: A peptide containing a novel FPGN CD40-binding sequence enhances adenoviral infection of murine and human dendritic cells doc
... hour of binding, regardless of the input titer (Fig. 1B).FPGN-containing peptides facilitate the uptake of adenovirus into CD40-expressing cells To test the ability of CD40 -binding peptides in ... Infection of cells by AdV-GFPcomplexed to the AAAA2-KBP peptide was at levels similar to those obtained in the absence of peptide, indicating that the FPGN motif is essential. To eliminate the ... facilita-ting adenovirus entry into CD40-expressing cells, we useda method in which a bifunctional peptide containing the peptide of interest is covalently linked to a peptide thatbinds to the adenoviral...
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Báo cáo khoa học: Ca2+/calmodulin-dependent kinase II signalling cascade mediates P2X7 receptor-dependent inhibition of neuritogenesis in neuroblastoma cells docx
... phospha-tidylinositol 3-kinase (PI3K), Akt and glycogensynthase kinase 3 (GSK3). Together, our resultssupport a role of P2X7 receptors in the regulation of neuritogenesis and in the fine control of the ... receptors in the maintenance of neuroblastoma cells in a nondifferentiated state, andpoint to P2X7 receptor antagonists as future potentialtherapeutic agents in the treatment of neuroblastomatumour ... allowed the exchange of the medium surrounding a cell in < 200 ms. Stock solu-tions of drugs were diluted daily in extracellular saline andincorporated into the perfusion system a few minutes...
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Báo cáo khoa học: "Who, What, When, Where, Why? Comparing Multiple Approaches to the Cross-Lingual 5W Task" pptx
... evaluation, the 5W task. The 5W task seeks to summarize the informa-tion in a natural language sentence by distilling it into the answers to the 5W questions: Who, What, When, Where and Why. To solve ... ambiguity. In the case of multiple top-level predicates, any of the top-level predicates may be chosen. In the case of passive verbs, the Who is the agent (often expressed as a by clause”, ... and then the remaining pieces of the sen-tence were returned as the What. The goal was to make sure to return a complete What answer and avoid missing the object. English-LF, on the other...
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Báo cáo khoa học: Super life – how and why ‘cell selection’ leads to the fastest-growing eukaryote doc
... value), the biomass concentration is determined only by the buffering capacity of the in owing medium (BCR,defined as the amount of acid or base required to change the pH of 1 L of the medium in the ... examined. Both the cell surface area and volumeincreased with the increasing number of generations asdetermined by the number of bud scars. Our calcula-tion of s ⁄ v ratios on the basis of these ... from the reservoir into the culture vessel responded to pHchanges in the culture vessel, and maintained the culturepH at the optimal pre-set value of 4.5. By this method,it was possible to maintain...
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Báo cáo khóa học: Mycoplasma pneumoniae HPr kinase/phosphorylase Assigning functional roles to the P-loop and the HPr kinase/phosphorylase signature sequence motif doc
... unknown. The three amino acidsG159, K160, and S161 are involved in binding of the triphosphate moiety of ATP or GTP [19,32]. The muta-tions G159A and K160A completely abolish the binding of ATP ... This is in good agreement with the proposal that S161 is involved in the catalytic activity, in addition to its role in triphosphate binding. In the HPrK/P of B. subtilis, the corresponding S160A ... curveindicative of co-operative binding was obtained. The dissociation constant Kdwas calculated to be5.4 ± 1.3 lM.For the HPrK/P of B. subtilis, it was shown that Piinhibits binding of...
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Báo cáo khoa học: Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells pdf
... the cells in the presence of DIF-1, we examined the effect of DIF-1 onglucose consumption by monitoring the glucose concen-tration in the incubation media (Fig. 3A). As expected,DIF-1 at the ... enzymes involved in glucose metabolism in 3T3-L1 fibroblasts To further investigate the mechanism of the action of DIF-1, we examined the effects of DIF-1 on the enzy-matic activities of glucose ... that the totalvolume of the reaction mixture was 1 mL in our experiment. In addition, to examine the direct effect of DIF-1 on the enzyme activity, the control cell lysates were assayed for the enzyme...
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Báo cáo khoa học: On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes ppt
... Mutations in the 23S ribosomal RNA in the vicinity of the double hook binding or in the b-hairpin of protein L22 were shown to bypass the elongation arrest [72]. The swing of protein L22 hairpin ... and the L22 doublehook should trigger the swing of the entire b-hairpin tip, in amanner similar to that caused by TAO binding. As a result of the swinging, the space for the bulky side chains ... arrest the biosynthesis of the leader peptide of E. coli tryptophanase (tnaC) operon [74]. In both cases the combination of tryptophane and the proline and the spacing between then (a tryptophane...
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Báo cáo khoa học: Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b doc
... is the mostimportant DNA–protein complex that contains the candidate transcriptional factors induced by TPA.Taken together, by examining the pattern of SII wesuggest that the in vitro DNA -binding ... for in vitro DNA -binding activity of the candidate transcriptional factors The critical role of the overlapping EGR-1/SP-1 regionwas further investigated by EMSA using nuclearextract obtained ... unknown Snail -binding regions might beinvolved in this process. This interesting issue is worthy of further investigation.We propose the model for TPA-induced sequential binding of SP-1, EGR-1...
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