Báo cáo khoa học: Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas-induced apoptosis ppt
Báo cáo khoa học: Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas-induced apoptosis ppt
... Journal compilation ª 2008 FEBS Reduced FAS transcription in clones of U937 cells that have acquired resistance to Fas- induced apoptosis Jeanette Blomberg, Kristina Ruuth, Maria Jacobsson, Andreas ... growth in progressively increasing con-centrations of stimulating Fas antibody [16]. To inves-tigate the molecular basis that underlies the resistance to Fas- induced apoptosis, the resistant cells ... resultsshowed that a decrease in Fas expression was the mostprominent reason for resistance, and that the reintro-duction of Fas expression abolished Fas resistance. Notably, the reduced amount of Fas in...
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc
... ganglion cells might contribute to providing chromophore to melanopsin to maintaintheir light sensitivities. The expression and function of RPE65c in other cell types in the retina remains to beinvestigated.Earlier ... recycling of 11cRAL through a processinvolving multiple enzymes and retinoid-binding pro-teins between photoreceptors and retinal pigment epi-thelium (RPE); it is essential for maintaining normalvision ... con-taining atRE (A), liposomes containing atRE in the presence of 1mM bipyridine (B) and liposomes containing atRE, in the presence of 1 mM bipyridine and 6 mM FeSO4(C). The generated retinoidswere...
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Báo cáo khoa học: Adipophilin protein expression in muscle – a possible protective role against insulin resistance pot
... per-formed to obtain more insight into the regulation of Adfp expression in muscle cells. We studied the effect of palmitic acid and oleic acid on insulin signaling andthe accumulation of TAG in relation ... both in HFD-P versus HFD-Oversus HFD-S). As a result, the homeostasis modelassessment of insulin resistance (HOMA-IR) index (cal-culated from fasting glucose and fasting insulin levels:fasting ... acid indeed impaired insulin signaling in C2C12 cells, which is in line with numerous studiesaddressing the effect of palmitic acid on variousaspects of insulin sensitivity [36–38].The protein...
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Báo cáo khoa học: "Enhancing Language Models in Statistical Machine Translation with Backward N-grams and Mutual Information Triggers" ppt
... probabilitiesduring a beginning -to- ending (left -to- right) decod-ing process, the succeeding context for the currentword is either yet to be generated or incomplete in terms of n-grams. The ... Pb(wm1) to wm1by looking at thesucceeding context according to Pb(wm1) =mi=1P (wi|wmi+1) ≈mi=1P (wi|wi+n−1i+1) (2)3.1 TrainingFor the convenience of training, we invert ... or-der in each sentence in the training data, i.e., fromthe original order (w1 wm) to the reverse order(wm w1). In this way, we can use the same toolkit that we use to train a forward...
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Báo cáo khoa học: Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals pdf
... major domainsfor its adaptor function, the importin b binding (IBB)domain in its N-terminus and the C-terminal NLS-binding domain. In the absence of importin b,anauto-inhibiting part of the ... Triton X-100 ⁄ -NaCl ⁄ Pifor 5 min. To stain thenuclei, the cells were incubated for 5 min at room tempera-ture in 1 lgÆmL)1DAPI (4¢6¢-diamidino-2-phenylindole)stain solution. Finally, cells ... peptide of the cargo binds in extended conformation to the binding pockets of the superhelical surface of importin a. These bindingpockets contain several conserved residues (e.g. aspara-gine,...
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Báo cáo khoa học: "Atestbed for research in origins of language" doc
... tion of results. 1 Introduction Over the past few years, a growing number of researchers have begun to look at some of the fundamental questions in linguistics in a new light, using new tools ... into subpanes that group related con- trols together. Figure 2 shows a stylised view of the interface, showing each of the main control panes. Access to interface functions is available to ... by a single window that allows the user to launch simulations, to set experimental parameters, to configure data reporting tools and even to write simple batch scripts to control ongoing simu-...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... incompetentprotein. Binding to CaM shifts this equilibrium to thebioactive competent protein.The region of the catalytic subdomain, where a single Cysresidue C75 was introduced (instead of a Tyr) in theconserved ... strong too.This indicates that this segment in the protein behavesrather independently from the rest of the molecule. It istempting to speculate that it adopts a similar conformation in AC–CaM to ... thequantification of microgram quantities of protein utilizing theprinciple of protein-dye binding. Anal. Biochem. 72, 248–254.36. Laemmli, U.K. (1970) Cleavage of structural proteins during theassembly of...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf
... latentgrowth factors have already been reported. Insulin-likegrowth factors are inactive when bound to insulin-likegrowth factor-binding proteins. Transforming growthfactor-b is produced ... found that single-chain HGFwas inactive in the presence of serine protease inhibi-tors in a hepatocyte proliferation assay, whereas thetwo-chain form was active even in the presence of theinhibitors ... activation of HGF in response to tissue injury In order to elucidate the in vivo roles of proteolyticprocessing of HGF, we examined the molecular forms of HGF by immunoblotting using a heavy chain-specific...
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Báo cáo khoa học: Molecular basis for specificities of reactivating factors for adenosylcobalamin-dependent diol and glycerol dehydratases pptx
... seems to result in the dissociation of a tightly bound damaged cofactoror adenine-lacking cobalamin [36,37]. To elucidate themolecular basis of the specificities of reactivating fac-tors in the ... consideredmodels of the damaged cofactor (adenine-lackingcobalamin) and intact coenzyme (adenine-containingcobalamin), respectively. As shown in Fig. 3A, whenthe diol dehydratase–CN-Cbl complex was incubatedwith ... [38,41].Specificities of reactivating factors in theactivation of inactive enzyme–CN-Cbl complexThe specificities of reactivating factors in the in vitroactivation of inactive enzyme–CN-Cbl...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
... Manning C, Akbarali Yet al. (2003) Responses to the proinflammatory cyto-kines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other jointtissues involve ... therapeutics as well. Together withour previous reports of the role of ESE-1 as an inducer of nitric oxide syn-thase in endothelial cells and as a mediator of pro -in ammatory cytokines in vascular and ... role of Ets factors in inflammation and in theregulation of cytokine-responsive genes has not beenstudied in detail. However, several genes, includingurokinase-type plasminogen activator, matrix...
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