... contaminat-ing protein that is either an accessory protein or aminor recombinant protein [34]. Studies show that anR88A mutation (arginine to alanine) in the nucleotide-binding site eliminates ... nucle-olin in the inhibition of c-Myc gene expression isshown in Fig. 5(A,D).The next logical series of experiments will examinethe differential binding of Sp1, Pol II, CNBP,hnRNP K, nucleolin ... [34].Identification of nucleolin as a c-MycG-quadruplex binding proteinTo identify potential c-Myc G-quadruplex-bindingproteins, an affinity chromatography method was usedfollowed by LC-MS/MS sequencing analysis...