Báo cáo khoa học: Sin3 is involved in cell size control at Start in Saccharomyces cerevisiae Octavian Stephan and Christian Koch ppt

... Journal compilation ª 2009 FEBS Sin3 is involved in cell size control at Start in Saccharomyces cerevisiae Octavian Stephan and Christian Koch Department of Biology, Friedrich-Alexander-University ... regu-lated by reversible recruitment of Sin3 and or Rpd3,rather than by regulating Sin3 ⁄ Rpd3 directly.A good candidate for a factor regulating Sin3 ⁄ Rpd3binding is Stb1, because it binds ... inactivation of SIN3 leads toan advanced induction of Start- speciﬁc transcription in G1daughter cells and that budding is initiated at asmaller cell size. Consistent with a direct role for Sin3 in...

Báo cáo khoa học: Visfatin is induced by peroxisome proliferator-activated receptor gamma in human macrophages pdf

... dataAcLDL12Visfatin/cyclophilin mRNAVisfatin/cyclophilin mRNAVisfatin/cyclophilin mRNACD36/cyclophilin mRNAFABP4/cyclophilin mRNAVisfatin/cyclophilin mRNAVisfatin/cyclophilin mRNAVisfatin/cyclophilin mRNA343 ... NAD pool is maintained, at least in part, by visfatin, which is important, forinstance, in b -cell insulin secretion [2]. Although stillcontroversial, visfatin is thought to have insulinmimetic ... TNF-a and IL-8 in THP-1 monocytes [8]. These effects of visfatin wereabolished when insulin receptor signalling was blocked[8], in line with the report that visfatin could bind and activate insulin...

Báo cáo khoa học: AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells pdf

... insulin action, such as insulin receptor sub-strates and adiponectin [8,9], resulting in obesity-relatedinsulin resistance [11–13]. In an in vitro model of ERstress induced by proteasome inhibition, ... [1].Adiponectin, which is abundantly expressed in adiposetissue, is a circulating peptide hormone with directinsulin-sensitizing activity. This adipokine has amelio-rative effects on insulin resistance ... putative ATF3-binding site in the 5’ ﬂankingregion, suggesting that direct binding of this tran-scription factor might negatively regulate AdipoR2expression. We hypothesize that ER stress-inducibleATF3...

Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx

... involved in vivo, possibly inducing cell death.T7 phage display methods are powerful and highthroughput tools for in vitro [12] and in vivo [13] iden-tiﬁcation of peptides or protein ligands. In ... plasmonresonance (SPR) analysis of binding betweenSQAG and MCAKThe full length MCAK protein is not soluble and is found in inclusion bodies. Therefore binding betweenSQAGs and a truncated version (MCAK184) ... centromere-associated kinesin (MCAK) is a molecular target ofSQAGs. The SQAGs inhibit the MCAK function and are likely to bind to its ‘neck region’. As this M-typekinesin is localized at centromeres and...

Tài liệu Báo cáo khoa học: "An ERP-based Brain-Computer Interface for text entry using Rapid Serial Visual Presentation and Language Modeling" ppt

... chan-nel is band-pass filtered. Second, each channel is temporally-windowed. Third, a linear dimensionreduction (using principal components analysis) is learned using training data and is subsequently ... letter.RDA is a modified quadratic discriminant anal-ysis (QDA) model. Assuming each class has amultivariate normal distribution and assuming clas-sification is made according to the comparison ofposterior ... ModelingLanguage modeling is important for many text pro-cessing applications, e.g., speech recognition or ma-chine translation, as well as for the kind of typ-ing application being investigated...

Báo cáo khoa học: "Abstracts of Papers for the 1963 Annual Meeting of the Association for Machine Translation and Computational Linguistics" pptx

... rules of relative clause formation are in- cluded as intermediate links in the chain of operations describing attributive phrases. The fact that in particular cases a relative clause in the one ... ‘Alcina’ wrote some operas in English,” is rewritten in a quasi-logical notation, “The X/A such that X/A is a composer and X/A wrote Alcina wrote some X/B such that X/B is an opera and X/B is ... syllabification and the relation of this phenomenon to the practice of word-breaking in dictionaries and style manuals. It is not at all clear at the start that dictionary word- breaking is subject...

Báo cáo khoa học: Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae pot

... panels in Fig. 2C), indicatingthat the pore-forming activity is determined by perox-isomal proteins but not by contaminating proteinsfrom other organelles.Fig. 1. Puriﬁcation of peroxisomes ... thefully-open state (Fig. 4B,C). These observations indi-cate that the intermediate amplitude is a substate of asingle-channel molecule inserted in the membrane,rather than amplitudes of two independently ... weakvoltage-dependence of channel gating. Interestingly,according to our preliminary data (unpublishedresults), the diameter of the peroxisomal channel is rather small (< 0.6 nm) and, in this sense, the channelshows...

Báo cáo khoa học: hhLIM is a novel F-actin binding protein involved in actin cytoskeleton remodeling ppt

... fluorescent protein (GFP)-tagged hhLIM pro-tein accumulated in the cytoplasm of C2C12 cells and colocalized withF-actin, indicating that hhLIM is an actin-binding protein in C2C12 cells.Overexpression ... identi-fication of their actin-binding domains. To date, noneof the actin-binding domain sequences registered in databases is present in hhLIM or CRPs. The goals ofthis study were to define the actin-binding ... actin co-sedi-mentation assay. hhLIM, SM22a or BSA were incubated with actin for 30 min in F-actin buffer containing ATP and Ca2+ and then centri-fuged at 10 000 g for 30 min. Proteins in...

Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

... endocannabinoid system byE2 in the ischemic striatum seems to involve the activa-tion of intracellular ERs. In fact, administration of theFig. 3. FAAH and CB1 receptor content in the striatum of rats ... in adult rats subjected to permanent ortransient MCAo [14,15], and in neonatal rats exposedto an intrastriatal microinjection of NMDA [41]. This is consistent with our data, documenting that ... brain were cut at 2 mm intervals from the fron-tal pole and incubated in TTC, which stains viable tissue red butnot infarcted areas. The infarct volume (B) was calculated by sum-ming the infarcted...

Tài liệu Báo cáo khoa học: NirF is a periplasmic protein that binds d1 heme as part of its essential role in d1 heme biogenesis pdf

... of a binding to a nucleotide-containingcofactor. This motif has also been found in severalother dehydrogenases involved in tetrapyrrole biosyn-thesis pathways, including CysGA and SirC in thesiroheme ... the C-terminal d1heme-containing domain ofcytochrome cd1. Strikingly, the axial ligand of iron in d1heme in P. pantotrophus cd1(His200) is conserved in NirF (His41); this conservation applies ... accumulation and consumption in Paracoccus pantotro-phus strains. Starter cultures were grownaerobically in LB with shaking before inocu-lation of mineral salt medium containing20 mM nitrate in...

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