Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
Báo cáo khoa học: A novel metallobridged bis(b-cyclodextrin)s fluorescent probe for the determination of glutathione doc
... according to the formula C = KS0⁄ S, where K = 3 (standard devia-tion = 1.36), obtained from a series of 11 reagentblanks, and S is the slope of the standard curve. The relative standard deviation ... solution of slightly excess cop-per (II) chlorate in an ice-water bath. Several drops of chlo-roform were further added, and the resultant solution waskept at 5 °C for 2 days. The solution was then ... Foun-dation of China (No.20575036) Important Project of Natural Science Foundation of Shandong Province inChina (No.Z2006B09) and the Research Foundation for the Doctoral Program of Ministry of Education(No.20060445002).References1...
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Báo cáo khoa học: Alternative splicing: good and bad effects of translationally silent substitutions pdf
... leading to the expression of novel splicing isoforms and ⁄ or loss of an existing one.This phenomenon can either generate new substrates for evolution or causegenetic disease when aberrant isoforms ... on splicing. A variety of tools are available to us for this purposeand further investigation of these sequence variants willnot only further our understanding of the splicing mechanism and ... understanding of the importance of cisregulatory sequences located either in the introns or in the coding sequence for the splicing process, the scien-tific world has become aware that there...
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... explain what makes an exon an exon or an intron an intron. The discovery of the basic splice site consensus sequences during the same years [4,5], and later on of enhancer and repres-sor elements, ... recruitment of the splicing factors to the targeted splicing competentcis-elements, thus forcing the machinery to use the nat-ural sites. Dominski and Kole [61] were the first topioneer the antisense-mediated ... review of the mechanisms that lead to pseudoexon activation in human genes and how the various cis- and trans-acting cellular factors regulate their inclusion.Moreover, we list the potential therapeutic...
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Báo cáo khoa học: Alternative splicing: global insights potx
... patterns of FOX1 and -2.Analysis of breast and ovarian cancer using an RT-PCR panel of alternative splicing events indicated thatone-third of cases of increased exon skipping in cancerwere ... NOVA-regu-lated alternative splicing of an exon in the GABAAgene. Analysis of alterations in alternative splicing in the neocortex of wild-type and Nova2) ⁄ )mice using an Affymetrix prototype ... sequence. The counting of reads corresponding to inclusion (upper) andskipping (bottom) allows for the estimation of ‘inclusion ratios’ for the different alternatively spliced isoforms. Alternative splicing: ...
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Báo cáo khoa học: Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action docx
... binding proteins Tat and Revare key regulators for the expression of the other viralgenes, for the synthesis of full-length genomic RNAand, ultimately, for the production of progeny virions(reviewed ... medica-tion schedules, the lack of patient compliance, side-effects associated with the drugs, and, ominously, the development of drug-resistant HIV. For these reasons, alternative or adjuvant treatment ... novelantiretroviral therapyAs stated above, the RNA binding proteins Tat andRev are key regulators for the expression of HIV-1viral genes, for the synthesis of full-length genomicRNA and, ultimately, for the...
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Tài liệu Báo cáo khoa học: a-Defensins increase lung fibroblast proliferation and collagen synthesis via the b-catenin signaling pathway doc
... released from granules of leukocytes and are implicated ininflammatory and fibrotic lung diseases. In the present study, the effects of a-defensins on the proliferation and collagen synthesis of lung ... proliferationand collagen synthesis of two other cell lines of lung fi-broblasts (HFL-1 and LL86). However, the mechanismresponsible for the a-defensin-induced proliferation of lung fibroblasts ... Foster City, CA, USA) with the conditions: 95 °C for 10 min, 40 cycles of 95 °C for 15 s and 60 °C for 1 min.All the primers and probes were purchased from AppliedBiosystems. The results were expressed...
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Tài liệu Báo cáo khoa học: "Using Multiple Sources to Construct a Sentiment Sensitive Thesaurus for Cross-Domain Sentiment Classification" doc
... domain, there isstrong potential for improving the performance of our method in this domain. The analysis of vari-ance (ANOVA) and Tukey’s honestly significant dif-ferences (HSD) tests on the classification ... where the value of the j-th element djis set to the total number of occurrences of the unigram or bigram wjin the review d. To find the suitable candidates to expand avector d for the review ... weights in the feature vector for the element u that also co-occur with the features in the feature vector for the ele-ment v. If there are no features that co-occur with both u and v, then the relatedness...
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Tài liệu Báo cáo khoa học: "Mining User Reviews: from Specification to Summarization Xinfan Meng Key Laboratory of Computational Linguistics " doc
... on the data and eval-uate the precision and recall. We also run the al-gorithms described in Hu and Liu (2004a) on the same data as the baseline.From Table 2, we can see the precision of base-line ... consider another kind of association: the association between features andunits of measurement. For example, in the sen-tence “A mobile phone with 8 mega-pixel, not verycommon in the market.” ... structured, provide a natural concep-tual view of products;2. Include only relevant information of the product and contain few noise words;3. Except for the product feature itself, usuallyalso provide...
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Báo cáo khoa học: Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline⁄serine-rich C-terminus doc
... colony clone were analyzed for the expression of the expected recombinant proteins.Bacterial expression and purification of the recombinant mouse SULTspGEX-4T-2 harboring either the full-length ... obtained with an autoFLEX II TOF ⁄ TOF (BrukerDaltonics, Billerica, MA, USA), and the data were ana-lyzed by a mascot search against the SwissProt database.Cosedimentation analysis with CSB andimmunoblot ... generatedthrough alternative splicing of their exon 1, and theytherefore differ only at their N-termini [9]. SULT2B1ahas been characterized as a pregnenolone sulfotransfer-ase, and SULT2B1b as...
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Báo cáo khoa học: Caenorhabditis elegans metallothionein isoform specificity – metal binding abilities and the role of histidine in CeMT1 and CeMT2 potx
... ESI-MS analysis of the samples at acid pH makes it possible todelimit the Cu species present in the sample. For the analy-sis of the apo-MT forms, obtained from recombinantZn–MT forms, and of the ... (CeMT1) and MT2 (CeMT2)wild-type and mutant forms The obtained pGEX constructs were transformed intoE. coli BL21 cells for the expression of the cloned cDNAsas fusions with GST. The recombinant ... of Biochemistry of the University of Zurich, Switzerland) andalso used as a template for the construction of regionscoding for the deletion mutant CeDHis and the independentN-terminal and C-terminal...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Chuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ