Báo cáo khoa học: Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics docx

... 405–426.Characterization of glutaminyl cyclase isoenzymes A. Stephan et al.6536 FEBS Journal 276 (2009) 6522–6536 ª 2009 Probiodrug AG. Journal compilation ª 2009 FEBS Mammalian glutaminyl cyclases and their isoenzymes have ... 2009)doi:10.1111/j.1742-4658.2009.07337.x Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate resi-dues at the N-terminus of several peptides and proteins from plants and animals. Recently, isoenzymes of mammalian ... hormone(TRH), gastrin, ﬁbronectin and neurotensin [1–3]. Glu-taminyl cyclases (QCs) have been identiﬁed in mammals,invertebrates and plants, catalyzing pGlu formationfrom glutaminyl precursors [4–8]....

Tài liệu Báo cáo khoa học: ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin docx

... –SO3PO3HNa. (A)Expanded view of peaks at m ⁄ z 2800.36 and 2832.35 and the fragmentation of the peak at m ⁄ z 2800.36. (B) Expanded view of peaks atm ⁄ z 2934.36 and 2950.35 and the fragmentation ... ubiquitous thiol-containing peroxidas-es that have been implicated in antioxidant defense and signal transduction.Although their biochemical features have been extensively studied, little isknown ... M)1Æcm)1), and, asindicated, 10 lM 2-Cys Prx, 3 mM ATP and 3 mM Mg2+. Proteinsolutions were excited at 370 nm and emission spectra werescanned from 410 to 600 nm. The spectral bandwidths...

Tài liệu Báo cáo khoa học: Physico-chemical characterization and synthesis of neuronally active a-conotoxins docx

... reduced and the cysteine residues alkylated in order to verify their identiﬁcation. Although there are standard procedures forreduction and alkylation, their application to conopeptideanalysis and ... to expand the diversity and utility ofthe pool of available a-conotoxins. Their identiﬁcationandcharacterizationdependonasuiteoftechniqueswith increasing emphasis on mass spectrometry and micro-scale ... a-conotoxins GI and GII together with the neuronally acting a-conotoxinsGIC and GID [1,5,10] and C. magus venom contains theTable 1. Comparison of selected known a-conotoxins from a4/7, a4/6 and a4/3...

Tài liệu Báo cáo khoa học: "Joint Word Segmentation and POS Tagging using a Single Perceptron" docx

... modeling and utterance classiﬁca-tion (Saraclar and Roark, 2005) and labeling and chunking (Shimizu and Haas, 2006). Though ourmodel is built speciﬁcally for Chinese word segmen-tation and POS ... joint segmentor and POS tagger.AcknowledgementsWe thank Hwee-Tou Ng and Mengqiu Wang for their helpful discussions and sharing of experimen-tal data, and the anonymous reviewers for their sug-gestions. ... isused to process known-words, and character infor-mation is used for unknown words in a similar wayto Ng and Low (2004). In comparison, our modelhandles character and word information simultane-ously...

Tài liệu Báo cáo khoa học: "Hand-held Scanner and Translation Software for non-Native Readers" docx

... computers (or even PDAs) and uses a hand-held scanner to get the input material. In otherwords, TwicPen consists of (i) a simple hand-heldscanner and (ii) parsing and translation software.TwicPen ... morphological and syntactic parsermakes it possible (i) to disambiguate toa large extent the word selected by theuser (and hence to drastically reduce thenoise in the response), and (ii) to handleexpressions ... German-French and Italian-French.1 IntroductionAs a consequence of globalization, a large and in-creasing number of people must cope with docu-ments in a language other than their own. Whilereaders...

Tài liệu Báo cáo khoa học: "Matching Readers’ Preferences and Reading Skills with Appropriate Web Texts" docx

... coherence(e.g.,(Miltsakaki and Kukich, 2004), (Barzilay and Lapata, 2008), (Bruss et al., 2004), (Pitler and Nenkova, 2008)) can also be integrated after psy-cholinguistic evaluation studies are completed and their ... infor-mation retrieval system (Collins-Thompson and Callan, 2004) is based on web data that have beenannotated and indexed off-line. Also, relatedly,(Schwarm and Ostendorf, 2005) use a statisticallanguage ... the Max-Ent classiﬁer to assign thematic labels and reportsresults for the super categories and basic cate-gories, which have been tested and shown to bereliable.3 Predicting difﬁcult words...

Báo cáo khoa học: "Extracting Opinion Expressions and Their Polarities – Exploration of Pipelines and Joint Models" pot

... expressionsegmentation and polarity labeling and comparethem to the joint opinion extractor and polarity clas-siﬁer by Choi and Cardie (2010). Secondly, we ex-tend the global structure approach and add featuresreﬂecting ... points in intersectionF-measure and 7 points in recall. The improvementsover Choi and Cardie (2010) ranged between 10 and 15 in overlap F-measure and between 17 and 24 inrecall.This is not only ... in(Johansson and Moschitti, 2010b), we showed thatglobal structure matters: opinions interact to a largeextent, and we can learn about their interactions onthe opinion level by means of their interactions...

Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx

... and TmEcRwere similar, as anticipated by their sequence similar-ity. In the PonA-bound HvEcR-LBD complex, theLBD is composed of 12 helices and three smallb-strands, and possesses a long and ... [261], planthormones and heat shock treatment have also beendeveloped.Future studiesEcR and USP (RXR) belong to the NR superfamily and have been identiﬁed in various insects and otherarthropod ... a-helices (H1 and H3–H12) and two shortb-strands, which make a three-layered helical sand-wich. This crystal structure contains three bindingpockets with signiﬁcantly lower ligand occupancy,Table...

Tài liệu Báo cáo khoa học: Mammalian mitotic centromere-associated kinesin (MCAK) A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents pptx

... collect and purifySQAGs from natural sources but we have succeeded inthe chemical synthesis of a number of forms. We have found a-anomers that possess potent antitumor activ-ity but do not have ... microtubles, SQAGs, and reactioncomponents were mixed, and then were incubated at 24 °C for30 min. The reaction mixture was centrifuged at 223 000 g and thesupernatant and the pellet were ... without MCAK184, with MCAK184 and ATP,with MCAK184 alone, and with MCAK184 and AMPPNP. Depoly-merized microtubules were visualized in the lane of the supernatant(S), and polymerized in the lane...

Báo cáo khoa học: Dual mitochondrial localization and different roles of the reversible reaction of mammalian ferrochelatase ppt

... structures, mechanisms and [2Fe-2S] clus-ters. Cell Mol Life Sci 57, 1909–1926.6 Taketani S (2005) Aquisition, mobilization and utiliza-tion of cellular iron and heme: endless ﬁndings and growing evidence ... ofcytochrome oxidase are phosphorylated both in vivo and in vitro [12]. NADH dehydrogenase and pyruvatedehydrogenase are phosphorylated and their activitiesare changed for physiological purposes ... pcDNA-HA-FECH, and incubated for 23 h. They were then ﬁxed, per-meabilized and reacted simultaneously with anti-ATP synthase and anti-HA sera to demonstrate localization of ATP synthase and ferrochela-tase....

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