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Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot

Báo cáo khoa học: Complex gangliosides are apically sorted in polarized MDCK cells and internalized by clathrin-independent endocytosis doc

Báo cáo khoa học: Complex gangliosides are apically sorted in polarized MDCK cells and internalized by clathrin-independent endocytosis doc

... iodine vapour. The position of GM1 is indicated on the right of the plate. Lipids migrated as multiple bandson the HPTLC plate because of the hetero-geneity of the fatty acyl chains of the ... domain (cytosolic tail, transmembranedomain and few amino acids of the stem region) of Gal-NAc-T fused to the N-terminus of YFP (GalNAc-T-YFP)was obtained by subcloning the corresponding cDNA ... rafts at the level of the TGN [19,20]. The prevention of the associa-tion of apical proteins with lipid rafts perturbs the apicalsorting of these proteins [21].Polarized distribution of sphingolipids...
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Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot

Báo cáo khoa học: Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles pot

... 5689–5702 ª 2009 The Authors Journal compilation ª 2009 FEBS Suppression of nuclear factor-jB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles Clara ... factor nuclear factor-jB (NF-jB) has been implicated. In this study, the in uence of CMR on the activity of NF-jB in macrophages and its modulation by the fatty acid composition of the particles ... changed by any of the four types of CRLPs.Effect of the fatty acid composition of CRLPs onCOX-2 mRNA expression The effect of CRLPs of varying fatty acid composition on expression of COX-2,...
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Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf

Tài liệu Báo cáo khóa học: Suppression of b1,3galactosyltransferase b3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycans Lydia Mare and Marco Trinchera pdf

... a linearized plasmid containing a 553-bpfragment of b3Gal-T5 cDNA, that includes the initial360 bp of the coding sequence and 192 bp of the 5¢untranslated region of the gene, placed in the ... obtained by Bio-Gel P-4 purification of the included volume of the column in (A), largeO-glycans (j), obtained as the included volume of the column in (C),and small O-glycans (s), obtained as the ... O-glycans, recovered in the includedvolume of the Bio-Gel P4 column, and large O-glycans,collected with the excluded volume of the Bio-Gel P4 and the included volume of the Sephadex G-50 column(Fig....
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Báo cáo khoa học: Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region pdf

Báo cáo khoa học: Suppression of a cold-sensitive mutant initiation factor 1 by alterations in the 23S rRNA maturation region pdf

... 5¢-side of the processing stem, gave rise to rRNA with the majority of termini in the mature form, whereas pD3, with amutation on the 3¢-side, gave rise rRNA with the majority of the termini in the ... rRNA termini are present in both the 50S and the 70S fractionsWe then investigated whether the observed extendedtermini present in the 23S processing stem mutantswere incorporated into the 50S ... there is a decrease in the extent of subunit association, as suggested in Fig. 6. In the case of the Drnc strain, this effect might haveresulted from decreases in the cellular pool of boththe...
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Báo cáo khoa học: Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells doc

Báo cáo khoa học: Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells doc

... Western blotting showed that the FOXO1 content decreased in the cytoplasm butincreased in the nucleus. In contrast, the level of PDX-1increased in the cytoplasm but decreased in the nucleus(Fig. ... cellsinduced by d-glucose. Suppression of NOX2 substantially restoresD-glucose-induced dysfunction and apoptosis of NIT-cellsTo investigate the potential role of the NOX family in the glucose-induced ... Expres-sion of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistancetoward apoptotic stimuli without affecting theirglucose-induced insulin secretion....
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx

Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx

... treatment resulted in an increase in the number of binding sites and a decrease of the affinity of the uPAR[38,39]. The quantification of uPAR expression by mea-surement of the amount of uPA bound ... through suppression of upstreamtargets of ERK. Thus, one of the functions of bikunin is the regulation of uPA synthesis and uPA binding by modulat-ing uPAR. It is most likely that the PMA-induced ... protein.However, little is known concerning the potential role of bikunin in the regulation of uPAR mRNA and its protein. In this paper, the positive modulation of uPAR mRNAand protein by PMA...
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Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx

Báo cáo khoa học: Suppression of microtubule dynamics by benomyl decreases tension across kinetochore pairs and induces apoptosis in cancer cells potx

... resulting in the formation of the kinetochorefibre, leads to a reduction in the concentration of the motor proteins and spindle checkpoint proteins [19].This reduction of checkpoint proteins is ... FEBSActivation of the spindle checkpoint proteinBubR1 by benomyl treatmentTo investigate the status of the checkpoint proteinBubR1 following benomyl treatment, we examined the cellular localization of the ... decreased the distance between the sister kinetochore pairs in metaphase cells andincreased the level of the checkpoint protein BubR1 at the kinetochoreregion, indicating that benomyl caused loss of...
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Báo cáo khoa học: Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs potx

Báo cáo khoa học: Suppression of heat- and polyglutamine-induced cytotoxicity by nonsteroidal anti-inflammatory drugs potx

... of the expression of hsps differed depending on the drug.Induction of thermotolerance of cells by INDAs IND and NDGA caused hsps to accumulate in mammalian cells, we next examined whether these ... temperature that is otherwiseinsufficient. In contrast, IND induces the expression of Hsp70 in human umbilical vein endothelial cells [18] orinduces the nuclear localiz ation of Hsc70 in mammaliancells ... he thermotoleran ce of cells [2]. Here, we further examined whether other NSAID ssuch as IND (a COX inhibitor) and NDGA (a LOXinhibitor) induced the expression of hsps in mammaliancells. IND...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... fluctuations in the levels of blood glucose [13], fatty acids [12,14,15] and certain amino acids [16].A linkage between fatty acid synthesis in the CNSand feeding behavior was uncovered with the findingthat ... directedinto the fatty acid synthesis pathway. Glucose metabo-lism in the CNS en route to fatty acids gives rise toATP and NADH, and inhibits isocitrate dehydroge-nase, thereby increasing the ... containing mitochon-dria maintain some ability to beta-oxidize long-chain fatty acids, adult neurons do not robustly oxidizelong-chain fatty acids [40]. The rate-setting step in long-chain fatty...
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Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

Tài liệu Báo cáo khoa học: Design, structure and biological activity of b-turn peptides of CD2 protein for inhibition of T-cell adhesion ppt

... ddition of penicillamine and cysteine to form a disulfide bond willincrease the number of amino acids in the peptide. The information obtained from truncating the peptides willalso be useful in the ... of b-turn in CD2 protein. In addition, the binding sites of the peptides to CD58 protein predicted by autodock were near the CD2–CD58 interface, either in the topcavityofCD58orneartheCC¢ sheet ... morepotential since it may directly interrupt the binding mech-anism of CD2–CD58. Inhibition of cell adhesion involvesinterrupting the interaction of key residues at t he protein–protein interface....
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