Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
Báo cáo khoa học: Amyloid structure – one but not the same: the many levels of fibrillar polymorphism potx
... 4601MINIREVIEW Amyloid structure – one but not the same: the many levels of fibrillar polymorphism Jesper S. Pedersen1, Christian B. Andersen2,3and Daniel E. Otzen41 Department of Biochemistry, Molecular ... releasefrom the cells, these amyloid structures would gradu-ally dissociate into active monomers in the blood-stream [17], which would imply that the amyloid structures formed by these hormones in ... antiparallel b-sheet structures[36,37] depending on the structure of the seeds. The peptide GNNQQNY(7-13) forms two different types of quasifibrillar crystal [38] and three different types of amyloid according...
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Báo cáo khoa học: "Re-Ranking Models For Spoken Language Understanding Marco Dinarelli University of Trento Italy" potx
... annotation, in terms of the edit distance from the manual annotation,among the 10-best hypotheses of the FST model;(C) as above but siis selected among the 100-best hypotheses. The pairs are also ... we noticed that many times the hypothesis ranked first by the SCLM is not the closest to the correct concept sequence, i.e. its er-ror rate using the Levenshtein alignment with the manual annotation ... nc(n1) is the number of chil-dren of n1and cjnis the j-th child of the noden. Note that, since the productions are the same,nc(n1) = nc(n2). ∆(n1, n2) evaluates the num-ber of STFs...
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Báo cáo Y học: Ruk is ubiquitinated but not degraded by the proteasome ppt
... variations in the level of endogenousRuk L, suggesting a long half-life for the protein (Fig. 4C).Furthermore, we examined the effect of selected inhibitors of protein degradation on the level of endogenous ... retains only the C-terminal coiled-coil region.Although the precise role of this Ruk/CD2AP family isstill unknown, they are involved in the control of apoptosisand the regulation of cytoskeletal ... SDS/PAGE,since their molecular masses differ from approximatly one kDa (A). An aliquot of each cell lysate was immunoblotted with anti-EE Ig to check the expression of EE-Ruk isoforms (B). The blot in the...
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Báo cáo khoa học: A designed curved DNA segment that is a remarkable activator of eukaryotic transcription potx
... the tk promoter, although the extent of activation differed among these segments. For the seg-ments from T4 to T32, the extent of transcriptional acti-vation correlated with the length of the ... expression of transgenes,which is of importance in many areas of the biologicalsciences. Moreover, such technology could lead to the development of useful nonviral vectors for gene ther-apy. Therefore, ... andinserted between the PmaCI and XhoI sites of pLHC20 ⁄ TLN. Then, the KpnI–DraI region of the resultingconstruct was isolated and inserted between the KpnI andNruI sites of pLHC20 ⁄ TLN-6....
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Báo cáo khoa học: Crystal structure of human cystatin C stabilized against amyloid formation pdf
... and B) in the asym-metric unit display the canonical cystatin fold, (N)–b 1– a–b2–L1–b3–AS–b4–L2–b 5–( C), with a five-strandedantiparallel b-sheet gripped around a long a-helix(Fig. 1). The AS is ... the presence of this extra bridgedoes not perturb the conformation of the main chain in the region of these point mutations. This is possiblebecause the side chain of Cys47 fills the space of ... of the b-sheet towards the interfacewith the a-helix. The side chains of Val31 and Tyr34(from the a-helix), Val66 (b3), Phe99 (b4), and Cys9 7– Cys117 (b4–b5), and the backbone of the SRA(4 4–4 6)segment,...
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Tài liệu Báo cáo khoa học: Crystal structure of an ascomycete fungal laccase from Thielavia arenaria – common structural features of asco-laccases ppt
... potential(E°) of the substrate must be low enough, as the rate of the reaction has been shown to depend on the dif-ference between the redox potentials of the enzymeand the substrate (DE °) [2 8–3 1].This ... attached to the T2 copper, as observed in the crystal structure of MaL. The unique fea-ture of TaLcc1 and MaL as compared with other laccases structures isthat, in both structures, the processed ... laccases [2 2–2 4]. The other phylum of the fungi, the Ascomycota or sac fungi, is much less studied,and only the crystal structure of Melanocarpus albomy-ces laccase (MaL) has been solved [25].The...
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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt
... and amidebackbone groups. The one exception to this is the location of the amide group of Lys204 at P3, wherethere is a break in the main-chain density at the 2.8rmap level. The corresponding ... primarily occurs by the formation of a hydrogenbond between the side-chain hydroxyl group of Tyr205and the importin-a main chain at the C-terminus of the ARM1 H3 helix. The hydrogen bond is ... formed by the loop connecting ARMrepeats 1 and 2 (Leu104–Pro111). Indicative of the tightness of the fit, there are a large number (30) of atom-to-atom van der Waals’ contacts between the Tyr205...
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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf
... [26]. These findingslead to the hypothesis that Fe-bound ApeSOD mimics the product-inhibited form and the shift of Tyr39 sup-presses the release of the peroxide product. This maybe one of the ... the ter-tiary structure of ApeSOD has not been elucidated.In the present study, for the first time, we describe the crystal structure of ApeSOD. In particular, we focuson the coordination of ... solution. Figure 1C illustrates the superimpo-sition of ApeSOD with the cambialistic SOD fromP. shermanii. The overall structures of these enzymeswere similar; the rmsd of the 747 Ca atoms was0.695...
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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc
... well. The hydrogen bond between the backbone nitrogen atom of Asp291 and the 3-phosphate of the substrate is the only interaction with the protein backbone; all other contacts are formedusing the ... identified. These are not part of the predictedbinding mode of phytate to PhyK. Out of the watermolecules included in the structure none is bound in the catalytic cleft. However, it cannot be ruled ... is the only direct contactbetween the protein backbone and the substrate. The side chain of Thr292 is found to recognize the 2-phos-phate in both the binding model of PhyK and the crys-tal structure...
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Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... of intrinsically dynamic behav-ior. These regions correspond to D11–E14, A46–R51,G53–C57, K83–G89, S101–A104, D117–N119 andG122–F125.Description of hirsutellin A structure The structure of ... transphosphorylation, which implies the ABFig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-siteresidues of the 20 conformers of the solu-tion structure of HtA. Catalytic ... connecting the second-ary structure elements. As in other ribotoxins, theseABCFig. 2. Representation of the 3D structure of HtA in solution. (A) Superposition of the 20 best structures obtained...
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