Báo cáo khoa học: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma pot
Báo cáo khoa học: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma pot
... S100A9 and LASP-1 may play animportant role in the development and progression of CRC. Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the ... role in the progression and metastasis of CRC.In summary, the techniques of proteomic analysis provide a dramatic means of screening for genesis- and metastasis -associated proteins in CRC. The results ... proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma Liang Zhao1,2,*, Hui Wang3,*, Xuegang Sun4 and Yanqing Ding11 Department of Pathology,...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... performed with thispreparation. The 1H NMR chemical shifts and the grouping of the signals in pairs (one pair at dH3.30 and 3.19, and the other atdH3.03 and 2.95; see below) resembled those of ... between the LPS of wild-type R C1 and phase variant 811 [ 24] or between the L PS of the avirulentwild-type 5097 and the corresponding mutant 137 [17]. As the mAb 2625 LPS epitope was found to be associated ... acid was the smallest one that displayed t hese signals and, moreover, the relative intensity of these signals was the highestcompared to other pools from the same strain. Therefore,further structural...
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... cells with developmental potentials that are indistinguish-able from that of the mother cell. This process is cen-tral to development, as well as to the maintenance of adult tissues in complex and ... cells(Fig. S1). On the other hand, the northern blotting and quantitative real-time PCR analysis also showed that the expression of differentiation marker genes such asfgf5, gata4 and gata6 was not ... 5C, and then analyzed the DNA contents of the cells by flow cytometry. Up until 4 h after the release, the DNA content patterns were essentially the same inPtb) ⁄ ) and wild-type ES cells, and...
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Báo cáo khoa học: "A Stacked Sub-Word Model for Joint Chinese Word Segmentation and Part-of-Speech Tagging" potx
... SegC and SegTagLare the predictions of the three coarse-grained solvers. For the three words at the begin-ning and the two words at the end, the three predic-tors agree with each other. And these five ... the reference of previous systems thatrepresent state -of -the- art results. The comparison of the accuracy between our stacked sub-word system and the state -of -the- art systems in the literature ... a theoretical average length of sub-words, we can still show the empirical one. The av-erage length of sub-words on the development set is1.64, while the average length of words is 1.69. The number...
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Báo cáo khoa học: Comparative structure analysis of proteinase inhibitors from the desert locust, Schistocerca gregaria pptx
... ifference i n the internal ¯exibility of t he molecules. The rigid nature of the second b strand is consistent with the presence of the indole r ing of Trp25 bridging strands 1, 2 and 3. It should ... and and in the 20±25 loop, as well as in the P2¢ and P 3¢positions of the binding loop. The residues with the greatestDdNHvalues are Thr16 and, more interestingly, Gln35. The majority of the ... elongatedshape with the N- and C-terminus located at the oppositeends. The backbone of the N-terminal residues adopts anextended conformation and runs parallel with the loopconnecting the second and...
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Báo cáo khoa học: "Fast Syntactic Analysis for Statistical Language Modeling via Substructure Sharing and Uptraining" ppt
... hypothesis in a local neighborhood of the current-best hypothesis, leading to a much more ef-ficient algorithm in terms of the number, N, of hy-potheses evaluated (Rastrow et al., 2011b); the ... accuracy of 97.2% on BN.We train the syntactic discriminative LM, with head-word and POS tag features, using the fasterparser and tagger and then rescore the ASR hypothe-ses. Table 3 shows the ... si.nch is the number of children of a subtree. qi.w and qi.t are the word and its POS tag in the queue. dist(s0,s1) is the linear distancebetween the head-words of s0 and s1.subtrees...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
... vascu-lar tissue of cotyledons and mature leaves, whereas, in the flowers, the anthers, connectives and filaments and the base and tip of the stigmata were stained. Similarto BPM2, BPM3 and BPM5 promoter:GUS ... cotyledons and in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves werestained in the vascular tissue of the leaf blade, whereas the petiole and older ... BPM proteins interact with members of the ERF ⁄ AP2 family. (A) Y2H assays demonstrate the assembly of BPM1(1–189) and BPM3 with RAP2.4 and RAP2.13, respectively. (B) Schematic drawing of the...
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Tài liệu Báo cáo khoa học: Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster doc
... may affect the metabolism of the target cells inmore ways than just the therapeutic purpose of the introduced gene. The normal function of nucleosidekinases is to provide the cells with deoxyribonucleo-tides ... : 4 in these cells. In the presence of exogenous dNs, the Dm-dNK expressing H9 cellsshowed a significant increase of 10- and sixfold of the dTTP pool (P<0.01) and of the dGTP pool (P ¼0.01), ... using the second-derivative maximum of eachamplification reaction and relating it to its respective stand-ard curve. The results from the quantitative PCR wereexpressed as the ratio of the mean...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... function of the kinetic constants of the enzymesinvolved in that pathway [3]. Application of this methodpointed to the inhibition of the rate of synthesis of ATP by the glycolytic route as a potential ... with H2O2, which produced a decrease in both the consumption of glucose and synthesis of ethanol. The apparent effect of H2O2on glycolysis was further confirmedby the lack of effect of ... concentrations of ATP and ADPwere considered as variables. With these characteristics, the maximum velocities in the direct (V8d, synthesis of ATP) and in the reverse (V8r,synthesis of ADP) directions...
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Báo cáo khoa học: Active-site-specific chaperone therapy for Fabry disease Yin and Yang of enzyme inhibitors pptx
... chaperone therapy. Synthesis of proteins takes place at ribo-somes, and newly synthesized proteins are secreted to the lumen of the ER. The ER has developed a ‘quality-control system’ to ensure the full ... proteins from reentering the refolding process, and serves as a signal for targeted ERAD. Inhibition of ER a-mannosidase I often delays the degradation of glycoproteins in the ERAD in favor of ... rather to the maintenance of the enzyme’s tertiarystructure.Molecular basis of the deficiency of human mutant a-Gal A enzymes The deficient activity of mutant a-Gal A enzymes canresult from the...
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