... reinstatement of sustained, specific non-responsiveness of the native immune system to self-antigen. Manipulation of T cell activation and differentiation pathways has been at the center of current ... can cause death (Berger and Koralnik, 2005; Langer-Gould et al., 2005; Ransohoff, 2005). As a result of this treatment related risk, Natalizumab utilization is usually reserved for patients with ... Multiple Sclerosis Pathogenesis and Treatment 15 7. References (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678....