... anti-SigF domain of MursiF, the RsbW ⁄ kinase domain (WKD), shows 40% similarityto B. subtilis RsbW, a serine kinase belonging to the GHKL family of kinases. This family of kinases isdefined by the presence ... common domain, RsbU ⁄ phosphatase domain (). The sequences homologous to other two domains, the RsbW domain () and the RsbV domain ( ), of Rv1364c (A) exist as independent genes in nonpathogenic ... nucleotide binding, and ispresumed to couple ATP binding to function-specificinterdomain associations [27]. Mutagenesis of the pro-posed hinge of the ATP lid in a GHKL family kinase,EnvZ,...