Báo cáo khoa học: Rapamycin inhibits lipopolysaccharide indu

Báo cáo khoa học: Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing the levels of octamer-binding factor-2 doc

... 2010 The Authors Journal compilation ª 2010 FEBS Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages ... an inhibitory effect of rapamycin on the lipopolysaccharide (LPS)-induced expression of both inducible nitric oxide synthase (iNOS) and...

Ngày tải lên : 22/03/2014, 17:20

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Báo cáo khoa học: Tumor suppressor p16INK4a ) modulator of glycomic proﬁle and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells ppt

... relationship between galectin-1 and the expression of the p16 INK4a protein could be delineated. In this sense, the p16 INK4a -dependent increase of the presentation of binding sites by reduced a2,6-sialylation ... reducing the extent of binding of labeled galectin-1 to the cell surface (data not shown). These results imply that the a 5 b 1 -integrin is a bin...

Ngày tải lên : 16/03/2014, 10:20

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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... full-length v-KIND; DKIND1, deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 ... lacking KIND2 (D KIND2 and DKIND1 + 2) failed to bind to GST-CD2 (Fig. S2A). This indicates that the KIND2 domain of v-KIND is involved in the interaction with t...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt

... binding. Only one ion pair seems to be involved in the binding process, which suggests the presence of a single binding site. Combining the results of our substrate competition studies with the ... governing the inhibition of the lethal factor protease by aminoglycosides. For example, the kinetic mechanism of inhibition by neo- mycin B has been reported as being...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt

... reaction. An interesting aspect of the H298E mutation is the orientation of the T300 ⁄ T302 side chains. Both have been implicated in the binding of ACP [2], probably by donating hydrogen bonds to one of ... all point to the orientation of H333 and its hydrogen bond donor properties as being the cornerstone of obtaining and ⁄ or retaining residual decarboxylase...

Ngày tải lên : 19/02/2014, 08:20

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Tài liệu Báo cáo khóa học: Non-speciﬁc depolymerization of chitosan by pronase and characterization of the resultant products pptx

... linear polymer, its freeze-drying results in the aggregation of the chains by inter- and intrachain hydrogen bonding network resulting in the formation of particle- like structure [1]. ESEM of ... 3600–3000 cm )1 in the spectra of both chitosan and LMWC indicated the absence of free -OH groups and the involvement of both -OH… 3and -CH 2 OH…6 in intra-...

Ngày tải lên : 19/02/2014, 12:20

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Báo cáo khóa học: Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line docx

... lgÆmL )1 castanospermine, an inhibitor of glucosidases I and II. In the presence of castanospermine, the levels of both Glc1Man9GlcNAc2 and peak X were increased (Fig. 2A,B). Under these conditions, the decreasing amounts ... 2003 Most of the evidence for the occurrence of degradation signals involved in ERAD has been obtained by studying the effect of inhi...

Ngày tải lên : 16/03/2014, 16:20

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Báo cáo khoa học: Purple membrane lipid control of bacteriorhodopsin conformational ﬂexibility and photocycle activity An infrared spectroscopic study docx

... under the loop region containing the charged acidic amino acids should produce a strain limiting the mobility of both the amino-acid-containing loops and the attached transmem- brane a-helices. These ... reconstitution in lipid dispersions containing vari- ous concentrations of NaCl which control the extent of lipid rebinding. The intrinsic mobility of the transmem...

Ngày tải lên : 17/03/2014, 03:20

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Báo cáo khoa học: Discriminating between the activities of human cathepsin G and chymase using ﬂuorogenic substrates potx

... Speciﬁc inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and pro- teinase 3: evidence for distinct cleavage sites within the aminoterminal domain of ... speciﬁcity of CG and chymase The crystallographic data reported by Hof et al. [1] indicate that the side-chain of Arg41 located on the 30S insertion loop in CG pro...

Ngày tải lên : 28/03/2014, 22:20

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Tài liệu Báo cáo khoa học: Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine ﬁbrosarcoma L929 cells doc

... by 3-methy- ladenine or small interfering RNA against LC3 and Beclin 1 promoted oridonin-induced cell apoptosis. The effects of p38 and nuclear factor- kappa B in oridonin-induced apoptosis and ... As shown in Fig. 9B, the inhibition of autophagy increased the oridonin-induced SubG 1 cell proportion in L929 cells. Furthermore, we knocked down the expressions of B...

Ngày tải lên : 18/02/2014, 13:20

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