... dowregulation of
NMNAT1 expression does not affect the rate of axon
degeneration in vitro.
Discussion
These data indicate that complete NMNAT1 gene
inactivation is incompatible with the normal develop-
ment ... Journal compilation ª 2011 FEBS 2679
Reducing expression of NAD
+
synthesizing enzyme
NMNAT1 does not affect the rate of Wallerian
de...
... apparent
additivity of the stoichiometries of the complexes ren-
dered by the separate moieties of CeMT1 and
CeMT2, the summation of their CD spectra did not
give rise in any case to spectra close to those of the
entire ... for the native and recombi-
nant Cd(II)–CeMT2 isoform [16,20]. The slight blue-
shift of the spectrum of Cd
6
Zn
1
–CeMT1 in relation to
th...
... which influences the flu-
orescence intensity. Therefore, the influence of the vol-
ume of buffer was measured. Because the volume of
buffer added (1.00–3.00 mL) had little effect on the
fluorescence ... fluorophores. The compound could be dis-
solved in aqueous solution and showed high binding
ability because of the two adjacent bis(b-CD)s.
Because of the conformation o...
... maintained.
Detection of the products of substrate oxygenation by the
adsorbed MMOH was achieved by holding the potential at
)0.5 V for 30 min in the presence of substrate and then
removing the liquid (50 ... fitted with GPES software. The
surface of the 4-mm diameter gold electrode (Oxford
Electrodes) was modified by cycling the electrode at
reducing potentials in th...
... consists of the set
of trees with whose root node is labelled X and
whose ith child is a member of T
B
i
.
1149
The set of trees generated by the CFG is T
S
,
where S is the start symbol, and the ... but it
has the advantage that the LDA distributions map
straight-forwardly onto PCFG nonterminals).
The terminals W of the CFG consist of the vo-
cabulary V of...
... (Milan Theater) and is not at the beginning
of that constituent. Finally, the syntactic depen-
dence trace of a word is the path of IOB values
from the root of the tree to the word itself. The
last ... used to guide the align-
ment. Starting from the bottom right entry of the
matrix, we go to the matrix entry from which the
value of the current cell is...
... function of man-
ganese in the transcriptional regulation of the nrd
operon [35] may not be considered in the light of the
results obtained in the present study. Rather, the
involvement of manganese ... to the catalytic site of the R1E subunit. As
reported in the Results, upon completion of substrate
conversion, the radical is then rapidly passed back
from t...
... mark the
boundary of the predicted substrate-binding pocket,
reveals that some of them are conserved in the inac-
tive isoform (i.e. Trp191 and Phe294). Even though
the precise role of these ... human ACMSD. The presence of the metal-
locofactor in human ACMSD might also be inferred
by our study on the enzyme pH dependence, showing
that the increase of the concen...
... quantitative strategy to offset the lack or
excess of kinetic energy (as a measure of temperature)
and its effect on enzyme activity.
Alternatively, we know of a number of examples of
qualitative strategies, ... considered in
the context of the relevance for the performance of
metabolic networks, because the theory of metabolic
control analysis states that enzyme...
... unable per se of regulating the expression of
ICAM-1, and other immune recognition molecules
other than Nor3.2-reactive CD1d.
To our knowledge, iron loading does not regulate
members of the MHC class ... cytometry revealed that the inhibition of cell
growth was due to a decrease in the percentage of cells
in the S and G2 ⁄ M phases of the cell cycle (Fig. 3B).
In...