... with valine, the cavity volume increased to 43 A˚3, reflecting a reduction in the surface area of the residue (% 59 A˚2)andintheinteractions occurring there (Fig. 8). Met88 resides in the Fig. ... the M88V mutant (by substitutionusing the same program) for the existence of internal cavities in this region in the structure. A significant cavity in the WTphage structure in the neighboring ... possessing a temperature sensitivegrowth phenotype. Overall, our data show how point sub-stitutions in the capsid protein, which affect either the packing or the interaction at the protein–RNA interface,result...