... Biological Chemistry,Academia Sinica, Nankang, Taipei, Taiwan.Fax: + 886 226530014,E-mail: shchiou@gate.sinica.edu.tw and A. H J. Wang, Institute of Biological Chemistry, AcademiaSinica, Nankang, ... Nankang, Taipei, Taiwan.Fax: +886 227882043, E-mail: ahjwang@gate.sinica.edu.twAbbreviations: SVMP, snake-venom metalloproteinase; MMP,matrix metalloproteinase; ADAM, a disintegrin-like and metalloproteinase ... Bothrops jararaca and Echis carinatus laekeyi,respectively,wereshowntobeabletoreleasetheactiveTNFa at the envenomation site [25], corroborating thestructural similarities between SVMPs and TACE asmentioned...