Báo cáo khoa học: "Rule-based Acquisition and Maintenance Lexical and Semantic Knowledge" doc

Tài liệu Báo cáo khoa học: "AUTOMATIC ACQUISITION OF SUBCATEGORIZATION FRAMES FROM UNTAGGED TEXT" doc

... sufficiently large corpora and sufficiently cheap computation have become available. Three recent papers in this area are Church and Hanks (1990), Hindle (1990), and Smadja and McKeown (1990). The ... Nonetheless, two obvious barriers still stand on the path to a fully automated SF dictionary: a deci- sion algorithm that can handle random error, and techniques for detecting many more types ... [Church and Hanks, 1990] K. Church and P. Hanks. Word association norms, mutual in- formation, and lexicography. Comp. Ling., 16, 1990. [Church, 1988] K. Church. A Stochastic Parts Program and...

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... loss-of-functionof BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, Rani Faryal1,2, Dara K. Mohammad1, Abdalla J. Mohamed1,4 and C. I. Edvard ... metazoans [1] and com-prise ﬁve members in mammals: Bruton’s tyrosinekinase (BTK), inducible T-cell kinase (ITK), TEC,BMX [also known as epithelial and endothelial tyro-sine kinase (ETK)] and TXK ... our under-standing of signaling mechanisms in general.Mutation spectrum in XLA and genotype–phenotype correlationsFigure 1 depicts the linear organization of the domainsin BTK and Fig. 2 shows...

Tài liệu Báo cáo khoa học: a-enolase: a promising therapeutic and diagnostic tumor target ppt

... 917–924.133 Fernandez Madrid F (2005) Autoantibodies in breastcancer sera: candidate biomarkers and reporters oftumorigenesis. Cancer Lett 230, 187–198.a-enolase in tumor diagnosis and therapy ... therapeutic and diagnostic tumortargetMichela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco NovelliDepartment of Medicine and Experimental Oncology, Center for Experimental Research and ... expressed in muscle tissues and c-enolase is found in neurons and neuroendocrinetissues [1,7–9]. The monomer of ENOA consists of asmaller N-terminal domain (residues 1–133) and a lar-ger C-terminal...

Tài liệu Báo cáo khoa học: Paradoxical interactions between modiﬁers and elastase-2 Patricia Schenker and Antonio Baici docx

... poly-disperse, and the chondroitin sulfates exist as co-poly-mers of the 4- and 6-sulfate isomers (Ch4S, Ch6S) withvarious compositions and mean molecular masses thatdepend on animal species and tissue. ... of the 4 and 6 isomers within the same chain, and also contain sulfate-free sequences. Ch4S from bovinetrachea contained 69% 4-sulfate and 25% 6-sulfate; Ch6Scontained 45% 4-sulfate and 54% ... and physiological ﬂuids, where the enzymeis engaged in multiple interactions with glycosamino-glycans bound to the matrix, or released from it, and naturally occurring inhibitors.Results and...

Tài liệu Báo cáo khoa học: How disorder inﬂuences order and vice versa – mutual effects in fusion proteins containing an intrinsically disordered and a globular protein docx

... con-tent of unordered stretches (50–59%) and a low con-tent in a-helices and b-strands (2–3% and 22–29%,respectively), whereas GFP is rich in b-strands (46%) and exhibits a low content in unordered ... thecontent of a-helices, b-strands, b-turns and unorderedregions of the individual intrinsically unstructured proteins and GFP moieties.Analytical gel ﬁltration and calculation of StokesradiiGel ... involved in the coordination of cell wallsynthesis and cell growth [18], the nucleoprotein and phosphoprotein from measles and Sendai viruses[19,20] and the Rhabdoviridae phosphoprotein [21].Although...

Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf

... develop-mental processes such as gametogenesis and neuro-genesis, in the maintenance of sensory and ciliatedtissues, and in immune responses [12–14]. HSF1- and HSF3-mediated mechanisms of cellular ... HSF1 and HSF2 in female [53,74] and male [71,75–77] germ cells. Neuronal differentiation and migrationwere affected in the HSF2-null cerebral cortex [78].Furthermore, the differentiation and maintenance ... Chr.8 q24.3 and mouseChr.15 D3 for HSF1; human Chr.6 q22.31,mouse Chr.10 B4 and chicken 63.95–63.98 Mb for HSF2; human Chr. X q12,mouse Chr. X B4 and chicken 0.252–0.265 Mb for HSF3; and human...

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... xenotoxins. At the blood–brainbarrier, and in placental trophoblasts, testis and bonemarrow, it provides protection of vital body parts and, in the gut, liver and kidney, Pgp helps to eliminate ... [15–18]. On the other hand, MRP1is present in virtually all human tissues and in mosthuman tumor cell lines and tumor samples [4]. Usingmice genetically deﬁcient in both the mdr1a and mdr1bgenes ... lM dye and 20 lM NBD-Cl (trian-gles) or 5 lM dye and 50 lM MK571 (squares). Another cell sample was depleted of ATP by incubation in a medium containing CCCP and 10 mM deoxyglucose and in...

Tài liệu Báo cáo khoa học: A facile method for expression and puriﬁcation of the Alzheimer’s disease-associated amyloid b-peptide pdf

... suppliedwith the enzyme, and contained Aba, Abb and Abcat40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP,dGTP and dTTP. The product ... Ab(1–40) and Ab(M1–40) are at least 97%pure. In the lanes containing Ab(1–42) and Ab(M1–42), there were prominent bands at approximately4 kDa and faint bands at approximately 14 kDa. Theband at ... and synthetic peptides are highly pure and behave similarly on SDS-PAGE and HPLC. Peptides were isolated by SEC and analyzed by reverse-phase HPLC [(A) Ab(1–40), (B) Ab(1–42), (C) Ab(M1–40) and...

Tài liệu Báo cáo khoa học: DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling pptx

... dynamics and oncogenic Ras signalingInsights from FAS, FAS ligand and RASSF1ASamir K. Patra1,* and Moshe Szyf21 Cancer Epigenetics Research, Kalyani, India2 Department of Pharmacology and Therapeutics, ... byH-Ras and K-Ras signaling that is facilitated by lipidrafts, on the one hand [98,144] (Fig. 3A), and radia-tion ⁄ chemotherapy can cause demethylation-inducedFAS expression, on the other hand ... affect mem-brane raft composition, on the one hand [91,172–178] and the DNA-methylation status [26–28] of many genes (e.g. FAS and CLU), on theother hand. EGCG can bind to GpC-rich regions of DNA....

Tài liệu Báo cáo khoa học: Calcium-binding to lens bB2- and bA3-crystallins suggests that all b-crystallins are calcium-binding proteins pptx

... proteins and induceluminescence peaks at 492 nm and 547 nm via energytransfer from Trp and Tyr residues [32]. Terbium bindsto bB2- and bA3-crystallins and induces luminescencepeaks at 492 and ... acidic(bA1 ⁄ A3, bA2 and bA4) and three basic b-crystallins(bB1, bB2, and bB3). b-Crystallins have high sequencesimilarity and identity [4]. Acidic b-crystallins haveboth N- and C-terminal extensions, ... calcium-binding to bB2- and bA3-crys-tallins, we suggest that all b-crystallins bind calcium. Our results haveimportant implications for understanding the calcium-related cataracto-genesis and maintenance...

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