Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
Báo cáo Y học: Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors potx
... stress (Eur. J. Biochem. 269) 3085 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors Jashmin Patel1, Laura E. ... study the roles of stress-activated signalling pathways on cell func-tion. We find that these stresses rapidly and profoundly inhibit protein synthesis and markedly alter the phos-phorylation and/ or ... consider their effectson protein synthesis when studying the effects of thesestress conditions on cell physiology. Other agents that inhibit protein synthesis (such as cycloheximide and anisomycin...
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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... University of Adelaide, South AustraliaTwo neuropeptides have been isolated and identi®ed from the secretions of the skin glands of the Stony Creek FrogLitoria l esueuri. The ®rst of these, the ... Ca2+calmodulin, the inhibition dropped by 50% in each case. In addition,these peptides also inhibit the activity of calcineurin, anotherenzyme that requires the presence of the regulatory protein Ca2+calmodulin. ... aturallesueurin by e lectrospray mass spectrometry, and HPLC.Bioactivity assaysAntimicrobial testing. Synthetic lesueurin was t ested forantibiotic activity by the M icrobiology D epartment o f the Institute...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... in the plasma membrane of dormant granulocytes in spite of the fact that they wereobserved abundantly in cytoplasm. Whereas reactiveoxygen species are classically thought of as cytotoxic and mutagenic ... from the column were pooled and employed to detect PAK and Rac by Western blot. Protein was quantitated by the method of Bradford [25], using BSA.Immunoprecipitation Protein samples of cytosol and ... member of the serine/threonine kinase family,which includes three types of isoform, PAK68, PAK65 and PAK62. They have been shown to have a high degree of sequence homology with the Saccharomyces...
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Báo cáo y học: "Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service"
... designed the study, collected the data, performed the statisticalanalysis and drafted the manuscript. HML and ES helped design the study and draft and review the manuscript. All authors have read and ... Norway.2Department of Anaesthesiology and IntensiveCare, Stavanger University Hospital, Stavanger, Norway.3Department of Surgical Sciences, Faculty of medicine, University of Bergen, Norway.Authors’ ... Norway, and its primary areas of operation are the mixed urban and rural districts of Rogaland County,which consist of just over 400,000 inhabitants. The medi-cal conditions treated by the HEMS...
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... satisfaction with the duration of effect of the study medication on their child'sADHD symptoms.Regarding medication satisfaction with tolerability of MTS, at study endpoint the majority of caregivers ... that the study medication decreased their child'sappetite. The majority of caregivers (88.1%) disagreedthat the study medication made their child feel sleepy dur-ing the day, but 34.8% of ... not used in the current study but part of the AIM-C)Are the following statements TRUE or FALSE for yourchild?• My child's behavior stays about the same throughout the day• My child's...
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Báo cáo y học: "Oral Rehydration Therapy for Preoperative Fluid and Electrolyte Management"
... therapy. We investigated the safety and effectiveness of oral rehydration therapy (ORT) for preoperative fluid and electrolyte management of surgical patients. Methods: The study consisted of ... of ORT for the preoperative fluid and electrolyte management of patients receiving general anesthesia before breast surgery, and in the follow-up study on the safety of ORT, we assessed the ... rehydration by administration of the study solutions. These observations can be inter-preted to mean that many patients were dehydrated in the morning of the day of surgery as a result of preoperative...
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Báo cáo y học: "Spinal Intramedullary Cysticercosis: A Case Report and Literature Review"
... to dissect the cyst with minimal injury to the peripheral tissue, the cystic liq-uid was partly withdrawn first and the slackened cyst was removed totally. The liquid was yellowish and transparent. ... and the spinal cord was found swollen. When a midline myelotomy was performed, a white cystic lesion was seen and clear fluid was then aspirated. The cyst wall of which slightly stuck to the ... discussed the principles of diagnosis and treatment of intramedullary cysticercosis in combination of literature review. Key words: intramedullary, cysticercosis, spinal cord Introduction Neurocysticercosis,...
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Báo cáo y học: " Helicobacter pylori induces mitochondrial DNA mutation and reactive oxygen species level in AGS cells"
... (CagA) protein a nd vacuolating cytotoxin (VacA) protein are the main virulence factors of Hp and closely relevant with the occurrence of gastric ulcer and carcinoma [2]. Most H. pylori strains ... mutations was de-pendent on the bacterial virulence factors. The changes in mtDNA in peptic ulcer tissues may further impair the ATP synthesis and increase the mtDNA copy number to compe n s a ... reduction of ATP synthesized in mitochondria and affect cell viability. Both the pathogenic factors of Hp (VacA and CagA), especially the VacA, play an important role in the Hp induced mtDNA...
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Báo cáo y học: " Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance"
... on the far wall of the common carotid artery along a 1 cm sec-tion of the artery proximal to the carotid bulb. The IMT was defined as the distance between the inti-mia-blood interface and the ... (Modula Analytics PP, Roche). Both intra-assay and inter-assay coefficient of variations were less than 2.1% and 4.4%, respectively. Plasma levels of IL-6 and TNF were measured by en-zyme-linked ... in-cluded 16 boys and 6 girls with a mean age of 11.1 ± 2.1 years (ranging from 7.6 to 14.8 years). Consent was obtained from the parents and the Ethical Committee of the Children’s Hospital of Zhe-jiang...
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Báo cáo y học: "Maitake Mushroom Extracts Ameliorate Progressive Hypertension and Other Chronic Metabolic Perturbations in Aging Female Rats"
... utilizes the synthetic tri-peptide substrate N-[3-(2-furyl)acryloyl] phenylalanylglcylglcine (FAPGG). FAPGG is hydro-lyzed by ACE to furylacryloylphenylalanine (FAP) and glycylglycine. Hydrolysis ... and throughout the re-mainder of the study. The entire BP profile and heart rate were as-sessed near the end of the study as shown in Table 3. Measured by another method, the SBP remained ... estimate activity of the NO system with an increase in SBP connoting augmented system activity. Cytokine Assay: Various cytokines were measured by ELISA methodology using kits from the following...
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