Báo cáo Y học: Nuclear proteins that bind to metal response

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... 2002 Ku proteins regulate transcription of the WD gene (Eur. J. Biochem. 269) 2161 Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens ... presence of nuclear factors that bind speciﬁcally to MREa. Two MREa-binding proteins of 70 and 82 kDa were puriﬁed using...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients

... effects and minimize toxicities [16-19]. Since digoxin is mainly eliminated via the kidneys, the renal function of the patients and its alteration during therapy are important factors to conduct ... concluded that Cys-C is a more useful marker for GFR than Cr [5]. A multinational expert meeting was held in Germany to summarize the latest findings also...

Ngày tải lên : 31/10/2012, 17:08

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Báo cáo y học: "Autofluorescent Proteins as Photosensitizer in Eukaryonte"

... death in yeast and in saccharomyces cerevisiae is documented 16,17 . In com- parison, in case of radical or reactive oxygen forma- tion, the amount of data investigations about pro- karyotes and ... interest on pharmacologically inactive molecules which are converted after activation by daylight to photosensitizing agents and which are able to dam- age, mutat...

Ngày tải lên : 26/10/2012, 09:48

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Báo cáo Y học: Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells pptx

... receptors. All- trans -RA inhibits the DNA binding activity of NFAT To understand the molecular m echanism of RA-induced inhibition of NFAT activity, we investigated whether the DNA-binding activity ... homeostasis of lymphocytes, and the main- tenance of peripheral tolerance. Retinoids, vitamin A and its natural and synthetic derivatives, regulate a wide array...

Ngày tải lên : 24/03/2014, 03:21

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Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx

... oxygenase and reductase domains is determined by the regulatory enzyme calmodulin that interacts a t a speci®c site between the t wo domains. In the cases of the nNOS and e NOS isoforms, the calmodulin ... catalytic oxygenase domain t hat binds heme, tetrahydrobiopterin and the substrate arginine, and (b) the electron-supplying reductase domain that binds N...

Ngày tải lên : 31/03/2014, 15:20

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Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot

... role for histone acetylation, namely to create binding sites on the amino-terminal tails of core histones for acetylated lysine binding domains, such as the bromodomain (reviewed in [91]), similar ... to the way that methylated H3-K9 serves as a binding site for chromodomain-containing proteins (des- cribed above). A mechanism like this may allow for the recrui...

Ngày tải lên : 31/03/2014, 21:21

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Báo cáo Y học: Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system docx

... 5¢-GAATTCATGCATCCCTTCTACACC-3¢ (TobF) 5¢-GTCGACTTAGTTAGCCATAACAGGC-3¢ (TobR) (59–345) 5¢-GAATTCCACATAGGGGAGAAAGTG-3¢ TobR (84–345) 5¢-GAATTCGGCAATCTGCCACAGGAT-3¢ TobR (114–345) 5¢-GAATTCGTGGATGATAATAATGAA-3¢ TobR (1–315) TobF 5¢-GTCGACTTAGCCTCCATAGGCTGC-3¢ (1–277) ... 5¢-GTCGACTTAGCCTCCATAGGCTGC-3¢ (1–277) TobF 5¢-GTCGACTTAAGGAAAAATAAATTCCTT-3¢ GFP–Tob (285–345) 5¢-GAATTCACCAATGGAATGTTCCCA-3¢...

Ngày tải lên : 31/03/2014, 21:21

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Báo cáo y học: "Using Medical Emergency Teams to detect preventable adverse events"

... critical care nurse, and a critical care-trained respiratory therapist. The MET can be activated by any hospital staff and is active 24 hours a day. Providers in our hospital use standard criteria ... calls. Within a week of the MET call, a multi- disciplinary team reviewed the information and rated the cause of the outcome using a previously developed rating...

Ngày tải lên : 25/10/2012, 10:06

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Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"

... pharmacologically active form of pravastatin is open hydroxyl-acid so that its hydrophilicity is markedly higher than that of other statins. The oral bioavailability of this statin is low due to degradation ... so that they are used in the treat- ment of many diseases such as osteoporosis, Alz- heimer disease, organ transplantation, stroke and di- abetes [...

Ngày tải lên : 25/10/2012, 11:10

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Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"

... risk. The main aim is creating validated biomarkers for early thera- peutic intervention in malignant diseases [47, 48]. A large number of organizations are now participating in cancer biomarker ... cellu- lar signal transductors and thus act mainly cytostati- cally compared with classical cytotoxic drugs require special timing of scans [68]. International guidelines f...

Ngày tải lên : 25/10/2012, 11:10

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