Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf
Báo cáo Y học: Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice pdf
... response to western-type diet. Specifically, we foundthat apolipoprotein E3 knock -in mice fed western-type diet for 24 weeksbecame obese and developed hyperglycemia, hyperinsulinemia, hyperleptin-emia, ... LDLr)/) mice do not becomeexcessively obese, and do not develop hyperglycemia and glucose intolerance in response to western-typediet. In our experiments, we studied the role of ApoE in the development ... diet-induced obesity and related metabolic dysfunctions. Indeed, a recentstudy showed that adipose-tissue-specific deletion ofthe LDLr -related protein makes mice less sensitive to obesity [49]. In...
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Báo cáo y học: "Maternal Outcomes According to Placental Position in Placental Previa"
... multiparity, previous abortion, previous cesarean section are frequently associated with placenta previa. They are accounted as risk factors of excessive bleeding and peripartum hysterectomy, even ... difference. And also these two groups showed no significant difference in maternal diseases such as endometriosis, myoma and incidence of myomectomy performed simultaneously during cesarean ... surgery were reviewed in all patients. To compare maternal outcomes, the hemoglobin level of prior to surgery, 1 day after surgery, and 3 days after surgery, the amount of transfusion during...
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Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"
... studies that are useful include α-fetoprotein (AFP) level, HCV genotype and RNA level. The AFP is widely used in screening of HCC, while HCV genotype and RNA level can later guide the treatment ... treatment. Besides genotypes 1, 2 and 3, other genotypes were not representative in the above mentioned studies, but in general, genotypes 4, 5 and 6 are thought to respond more like genotype 1. ... pharmacokinetics which allows once-weekly subcutaneous injections as compared to the non-pegylated interferons, which required three times weekly injections. There are currently two available pegylated...
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Báo cáo y học: "A Practical Approach to Management of Chronic Hepatitis B"
... virological responses to these treatments. Comparing to HCV treatment, the frequency needed for follow-up HBV DNA measurement is less defined during HBV treatment. However, it is recommended whenever ... should be monitored regularly. The interval of follow-up visits may vary depending on regimen and duration of the HBV treatment. For instance, those on IFN therapy may need to be monitored every 4-6 ... improved histology. The overall response to one year of ADV treatment as determined by HBeAg seroconversion is approximately 12% (vs. 6% in placebo group) that could be increased to 23% by the end...
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Báo cáo y học: "An innovative method to evaluate the suture compliance in sealing the surgical wound lip"
... 355the challenge of being able to select the thinnest suture, especially the one with non-absorbable material, pos-sibly non-filamentous, easy to be tied, and easily and painlessly removed. ... permeability of the three different suture threads examined in this study was tested using bro-moethylene blue stain. The results showed that the polyurethane suture threads were the most imperme-able, ... laparocele surgery. Note that the scar in the middle part of the suture line where polyurethane was used is very thin, as compared to wider scars in the lateral segments of the suture line where...
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Báo cáo Y học: Complexation of ytterbium to human transferrin and its uptake by K562 cells pot
... the molecules within individual cellsusing appropriate fluorescent probes [36–38]. The greenfluorescence inside cells indicated that FITC-Yb2-Tf enteredcells and may have been located in cytoplasm ... (Fe2-transferrin) complex intoK562 cells. The results demonstrate that the complex ofYb3+-transferrin complex was recognized by the transferrinreceptor and that the transferrin-receptor-mediated mech-anism ... iodide labeled DNA and RNA in cellsindicated that the Yb3+entered the cells. The Yb3+-trans-ferrin complex inhibited the uptake of the fluorescein labeledferric-saturated transferrin (Fe2-transferrin)...
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Báo cáo Y học: Oxidation of propionate to pyruvate in Escherichia coli Involvement of methylcitrate dehydratase and aconitase pot
... additional repetitive extragenic palindromic element(REP-element) between the prpB and prpC coding sequence. TheDNA sequence of the intergenic region containing the REP-element isshown in the upper ... identified as methylcitrate [1].Further investigations revealed other enzymes necessary fora functional methylcitrate cycle. The enzymes, however,were only partially characterized and no genomic ... dissolved in 100 lL nuclease-free water. Theintensity of the digoxygenin label of the probes was checkedby cross-linking the specific probes on a nylon membrane and detection of the label by standard...
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Báo cáo Y học: Amyloid-fibril formation Proposed mechanisms and relevance to conformational disease docx
... formation and conformational disease areunderlined. Existing models for the mechanism need to betested by experiment. The kinetic and energetic bases of theprocess are reviewed. The main controversial ... diseases, many ofwhich are hitherto incurable, and secondly, because itremains to be explained in physical terms (energetically and structurally). The process leads to fibrous aggregates in theform ... compo-nents of amyloid as observed in vivo remains to bedetermined. In vitro studies of the disease related proteins,as well as other amyloidogenic proteins, have beenconcerned mostly with the...
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Báo cáo Y học: The unorthodox histidine kinases BvgS and EvgS are responsive to the oxidation status of a quinone electron carrier ppt
... histidine kinasesmay either be the consequence of a decrease in the histidinekinase activity, or, alternatively, of an increase in an intrinsicautophosphatase activity present in the BvgS and EvgSproteins ... respiratorydiseases in man and animals, respectively [3,4]. It controlsexpression of a huge virulence regulon including the genesencoding the pertussis and adenylate cyclase toxins and several ... system does not onlycontrol expression of virulence related functions but alsoseveral housekeeping genes including cytochrome c and cytochrome d oxidases of the respiratory chain and severalputative...
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Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx
... NLSinv)were cultured, and the proteins were purified as describedpreviously [45].Nuclear import assayDigitonin permeabilized HeLa cells were prepared essen-tially as described by Adam et ... coding sequenceinto mammalian expression vector pEGFP-C1 (Clontech). To introduce deletions into the NLD-I sequence of nPTBwe used a two-step PCR method. In the first step we usedthe following ... collected and washed three timeswith binding buffer. After washing, one-twentieth of thebeads were removed and the amount of immobilized GSTfusion proteins were analyzed by SDS/PAGE. The rest...
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