... function, as well as in the regulation of the heartbeat, is now well establishedand, increasingly, their importance in other organs isbeing acknowledged [3–7]. Generally, the G- proteinb ⁄ ... the role of the S ⁄ Ts in the regulation of GIRK1 via PKA in a manner that is unbiased by the eventual contributions of the other subunits in a het-erooligomer, the corresponding mutations were ... a markedincrease in the affinity of the phosphorylated channelprotein to G b ⁄ c[20]. A signalling complex comprising(amongst other signalling molecules) GIRK1, GIRK4, G b ⁄ c, PKA, PP2A and...