Báo cáo khoa học: Deadenylation of interferon-b mRNA is mediated by both the AU-rich element in the 3¢-untranslated region and an instability sequence in the coding region pot
... Deadenylation of interferon-b mRNA is mediated by both
the AU-rich element in the 3¢-untranslated region and an instability
sequence in the coding region
Muriel Paste
´
, Georges Huez and ... However, the deadenylation and
degradation of IFN-b mRNA is under the control of two
independent elements, one of which is located in...
... approaching the reversal potential of the
ANT [23]. At 0 mV, during which both the ANT and
the F
0
F
1
-ATP synthase operate in reverse mode, the
increase in ADP–ATP exchange rate mediated by the
ANT ... an
insignificant increase (1.38–1.7%) in the ADP–ATP
exchange rate mediated by the ANT in maximally
polarized (forward mode of both ANT and ATPase...
... Chemistry and Bioengineering, Changsha University of Science and Technology, Hunan, China
3 College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, ... promote the expres-
sion of SR-BI, resulting from the binding to putative KLF4 binding
element on the promoter of SR-BI. All results indicate a potential function...
... that induction of apt1 and and induc-
tion of gpx1 depend solely on the Pap1 and Atf1 tran-
scription factors, respectively, and that induction of
ctt1 is dependent on both Pap1 and Atf1 in Sc. ... ubiquinone biosynthesis occurs in
mitochondria in yeasts. In summary, our results indicate that coq7 is
required for ubiquinone biosynthesis and the coq7 mutant i...
... or cofactor. In detail, the N-terminal
module is the homocysteine (Hcy)-binding domain; the
second domain binds 5-methyltetrahydrofolate, the third
domain binds CH
3
-Cbl; and the fourth domain ... design of inhibitors of methionine synthase. Our results indicate that
the potency of the tested compounds is related to a planar region of the
inhibitor that can...
... hydrolysis to aldehyde and
quinolamine. The band disappeared on admission of
oxygen into the solution. The band at 350 nm formed by
LCAO, upon bleaching of the radical, suggests that the
neutral ... as
shown by the measured amounts of H
2
O
2
, by the initial
intensity of the radical spectrum and by the bleached
500 nm band. Which of the two equilibri...
... chain
length of the cells expressing the mutant enzymes,
and sedimentation of the cells in standing cultures;
(c) their enzymatic activities, both in the cell and
supernatant fractions; and (d) autolysis ... proteins, but not in archaeal proteins [14].
From an analysis of proteins containing LysM
domains it is clear that the number of domains and
their po...
... characterized by swelling of organelles and cells,
followed by lysis of the plasma membrane and random
DNA degradation. In contrast, apoptosis is a process that is
characterized by cell shrinkage, ... was
suppressed by SB202190, a potent inhibitor of p38, in F9
cells. These findings indicated that the activation of p38 is an
essential step for apoptosis in...
... enthusiastic
assistance with statistical analyses. This work was sup-
ported by the Endocore Research Trust, the Maurice
and Phyllis Paykel Trust, and the New Zealand Lot-
tery Grants Board, and by Programme ... caspase-3
activation by 30%; as did combined SB203580 and JNK inhibitor I, by
about 70%; and the combination of SB203580, the JNK inhibitor I and a
ca...
... Because
these inhibitors decrease both hyperglycemia and
hyperinsulinemia, they reduce insulin resistance and
stress on the beta-cells of the pancreas, thus preventing
further insulin-dependent disorders ... for use in kinetic and inhibi-
tion analysis as well as future use in structural studies.
Kinetic analysis confirmed the enzyme activity of the
recombinant protein,...