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Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx

Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx

Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx

... 2003 Telomere length detection (Eur. J. Biochem. 270) 403REVIEW ARTICLE Assessment of telomere length and factors that contribute to its stability Sabita N. Saldanha1, Lucy G. Andrews1 and ... evaluated.Drugs that assist in telomere shortening may contribute to tumor regression. Therefore, factors that contribute to telomere stability may influence the efficiency of the drugs that have potential ... [79,80].Importance of telomeres and telomere length Telomeres extend up to 10–15 kb at each humanchromosome end (Fig. 1) and protect the ends of thechromosomes. The geometric configuration of telomeresappears...
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Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc

Báo cáo khoa học: Assessment of porcine and human 16-ene-synthase, a third activity of P450c17, in the formation of an androstenol precursor doc

... biosynthesis of androste-nol, a potential endogenous ligand for the orphan receptorsconstitutive androstane receptor and pregnane-X-receptor,requires the presence of enzymes of the steroidogenic ... also in theproduction of androstadienol which is considered to be anintermediate in the 16-androstene pathway leading to thebiosynthesis of androstenol and of 5a(16)androsten-3-one, apheromonally ... detoxification of drugs and of a largeseries of exogenous compounds from the environment,androstenol and 5b-pregnanedione that modulate cyto-chrome P450 levels could have a profound effect on thedetoxification...
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Báo cáo khoa học: Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening doc

Báo cáo khoa học: Selection of full-length IgGs by tandem display on filamentous phage particles and Escherichia coli fluorescence-activated cell sorting screening doc

... time-consuming and challenging [40–43]. To reduce the initial library to a size that is manage-able by FACS and to demonstrate that full -length IgGlibraries can be displayed on phage particles and undergo ... highest-affinity and lowest-affinity IgGswere determined to have KDvalues of 1 and 440 nm,respectively.Enrichment of high-affinity and moderate-affinityIgGs To evaluate the utility of tandem phage ... IgG to the extracellular fluid. Twocolor flow cytometry steps, using PA63–fluorescein iso-thiocyanate (FITC) and Alexa Fluor 647–anti-(humanIgG) to monitor for affinity and expression of full-length...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

... identified by its ability to bind to enhan-cer regions of SV40 and human metallothionein IIA [1].The AP-2 family of transcription factors is composed of five members: AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e[2–7], ... day 16.5 and display a failure of chondrocyteprogenitor cells to differentiate into hypertrophic chon-drocytes [56].Two members of the Runx family of transcription factors, Runx2 and Runx3, ... treatment of the chick face with RA, and this is accompanied byan increase in apoptosis [73]. The authors of this studyascribe the regulation of outgrowth of limb buds and patterning of the digits to...
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Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

Tài liệu Báo cáo khoa học: Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr docx

... mmdithiothreitol for 30 min and then assayed. The level of inactivation was determined by comparing the specificactivity of oxidized PhyAsr to that of enzyme that had notbeen exposed to H2O2. ... average B -factors of the P-loop residues in theunoxidized and oxidized structures were 14.3 A˚2 and 15.4 A˚2, respectively. This is 4–5 A˚2lower than theoverall B -factors of the structures ... strength from 100 to 500 mm enhanced thebinding of InsP6 to PhyAsr (Table 1). Given the absence of structural changes as a function of ionic strength and ligand binding, the effect of ionic strength...
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Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors docx

Tài liệu Báo cáo khoa học: Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors docx

... omparison of hydroden bonds (2.4–3.6 A˚) of inhibitors OE, RE and SE towards their HIV-1 proteases. Stated numbers are distancesbetween inhibitor and protease atoms in A˚.Reside of Atoms of Inhibitor ... quality of refined m odel of t he nativeHIV-1 protease c omplexed with inhibitor OE.ParameterNo. of non-H protein atoms 1516No. of non-H inhibitor atoms 50No. of refined water oxygens 159R factor ... by t he fact that it hasthe lowest B -factors of the whole inhibitor.The w ater molecule W401 that hydrogen bonds to themain chain NH group of both flaps as well as to theinhibitor carbonyls...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf

... 2004 Anti-mitogenic action of EPA and DHA (Eur. J. Biochem. 271) 4465Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAsInduction of cyclin D1 is one of the e ... effects of mitogenic factors lea ding to cell c ycle re-entry, G1-phaseprogression, and transition to t he DNA synthetic S phase.We examined the effects of PUFA on cyclin D1 by measuring its concentration ... addition to growth factors or cytokines, we have shown previously that n-3 polyunsaturated fatty acids (PUFAs) act in opposition to n-6 PUFAs by modulating various steps of the inflam-matory process....
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "Applications of GPC Rules and Character Structures in Games for Learning Chinese Characters" doc

... Learning to read and write Chinese characters is a challenging task for learners of Chinese. To read everyday news articles, one needs to learn thou-sands of Chinese characters. The official ... as the manage-ment of players’ accounts and the maintenance of players’ learning profiles. Yet, due to the page limits, we focus on the parts that are most relevant to the demonstration. ... which could be used to rebuild “甲” in a sense. By comparing the internal codes of Chinese characters, it is possible to find that (1) “理” and “裡” include “里” and that (2) “理” and “玾” are visually...
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Tài liệu Báo cáo khoa học: Consequences of COP9 signalosome and 26S proteasome interaction doc

Tài liệu Báo cáo khoa học: Consequences of COP9 signalosome and 26S proteasome interaction doc

... from cauliflower in the presence of ATP and phosphatase inhibitors indicated that the CSN1 and CSN6 subunits coelute in the same fractions as subunits of the 26S regulatory complex. Moreover, coimmuno-precipitations ... proteins such as p53 and regulatethe stability of the tumour suppressor towards the Ubsystem [11]. It has been demonstrated that subunits of the eIF3 complex interact with components of the CSN[12,13]. ... cells as a negative regulator of photomorphogen-esis [1]. It occurs in all eukaryotic cells and consists of eight core subunits, CSN1–CSN8 [2]. Six of the CSNsubunits contain PCI (proteasome,...
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Tài liệu Báo cáo khoa học: Prevention of thermal inactivation and aggregation of lysozyme by polyamines docx

Tài liệu Báo cáo khoa học: Prevention of thermal inactivation and aggregation of lysozyme by polyamines docx

... presence of 100 mMspermidine and spermine, the inactivation curve of 1.0 mgÆmL)1lysozymewas identical to that of 0.2 mgÆmL)1lysozyme. The rateconstants of inactivation in the presence of spermidine ... Institute of Science and Technology, Ishikawa, Japan;2Department of Bioscience,School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan;3Department of Synthetic Chemistry and ... precisemechanism of formation and inhibition of aggregates, ourdata imply that the formation of ion pairs with localnegative charges would effectively increase the net charge of the protein, leading to increased...
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