... generation ofphosphatidylinositol (3,4,5)-trisphosphate from phos-phatidylinositol (4,5)-bisphosphate, a reaction that is reversed by the enzymes phosphatase and tensin homo-logue (PTEN) and ... metabolism,development, cell cycle progression, migration and sur-vival [1–4]. The Akt subfamily of protein kinases con-sists of three isoforms – Akt1, Akt2 and Akt3 (alsotermed PKBa, PKBb and ... targetof rapamycin, and ribosomal S6 kinase 1 signaling path-ways by thyroid- stimulating hormone (TSH) and stimu-lating type TSH receptor antibodies in the thyroid gland. J Biol Chem 278,...