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Báo cáo khoa học: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole ppt

Báo cáo khoa học: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole ppt

Báo cáo khoa học: Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole ppt

... Thyroid Ca2+/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil and methimazole Andrea C. Freitas Ferreira, Luciene de Carvalho Cardoso, Doris Rosenthal and Denise ... effects.Keywords: antithyroid drugs; H2O2;NADPHoxidase; thyroid. The mechanism by which antithyroid drugs, such as propylthiouracil (PTU) and 1-methyl-2-mercaptoimidazoleor methimazole (MMI), block thyroid ... of TPO by MMI and PTU involves a reaction between these drugs and theoxidized TPO heme group, which is produced by theinteraction between TPO and H2O2. In addition, Taurog and Dorris [5]...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf

Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf

... with this hypothesis, we have shown recently thatMUC2 and MUC4 are transcriptionally regulated by Cdx homeodomain proteins and GATA factors[14–16]. Thyroid transcription factor-1 (TTF-1) is animportant ... 10) and cold T84 (lane 16); supershift analysis with anti-GATA-4 (lanes 5, 11 and 17), anti-GATA-5 (lanes 6, 12 and 18) and anti-GATA-6 (lane 7, 13 and 19) IgGs. The DNA–protein complex (GATA) and ... < 0.05 was considered to be significant and is indicated by an asterisk. Three asterisks indicate P < 0.001.AcknowledgementsWe thank Dr M P. Buisine (Inserm U837, Team #5,Lille, France)...
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Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts ppt

Báo cáo khoa học: Protein transport in organelles: Dual targeting of proteins to mitochondria and chloroplasts ppt

... challenges in this field is provided, and the insights that may be gained from a greater under-standing of the mechanism of dual targeting for thetargeting of location-specific proteins is discussed.Targeting ... chloroplasts (Toc)64 and Toc159 system used by proteins involved in photosynthesis [36]. TheToc159 family in Arabidopsis consists of four proteins:Toc159, Toc132, Toc120 and Toc 90 [37]. It is possiblethat ... complete understanding of dual targetingalso requires an understanding of why it occurs. This is probably best achieved by converting dual-targetedproteins to location-specific isoforms and assessingorganelle...
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Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx

Báo cáo khoa học: Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines docx

... pro-liferation and suppress apoptosis of islet cells [53–55].It is conceivable that this effect of leptin is mediated by activation of STAT5.An unexpected finding was the capability of Tyr1138,which is ... mammals and birds [15,16]. Tyr1138 is located in acanonical box3 motif (Tyr-x-x-Gln) and recruits thetranscription factor STAT3, which is subsequentlyphosphorylated by JAK2, dimerizes and translocatesto ... activation of STAT factors wasmonitored by Western blot analysis with phospho-spe-cific antibodies and by reporter gene assays (Fig. 4).Consistent with the established consensus sequence forbinding...
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Báo cáo khoa học: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis pptx

Báo cáo khoa học: G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis pptx

... generation ofphosphatidylinositol (3,4,5)-trisphosphate from phos-phatidylinositol (4,5)-bisphosphate, a reaction that is reversed by the enzymes phosphatase and tensin homo-logue (PTEN) and ... metabolism,development, cell cycle progression, migration and sur-vival [1–4]. The Akt subfamily of protein kinases con-sists of three isoforms – Akt1, Akt2 and Akt3 (alsotermed PKBa, PKBb and ... targetof rapamycin, and ribosomal S6 kinase 1 signaling path-ways by thyroid- stimulating hormone (TSH) and stimu-lating type TSH receptor antibodies in the thyroid gland. J Biol Chem 278,...
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Báo cáo khoa học:

Báo cáo khoa học: "Fast Syntactic Analysis for Statistical Language Modeling via Substructure Sharing and Uptraining" ppt

... qi.w and qi.t are the word and its POS tag in the queue. dist(s0,s1) is the linear distancebetween the head-words of s0 and s1.subtrees s0, s1, . . . (s0 is the top tree) and Q ... ENDORSE A CANDIDATE(9) AL GORE HAS PROMISED THAT HE WOULD ENDORSE A CANDIDATE FOR(10) AL GORE HIS PROMISE THAT HE WOULD ENDORSE A CANDIDATEFigure 1: Example of repeated substructures in candidate ... initial state is π0= {∅, {w0, w1, . . .}}, and final states occur whenQ is empty and S contains a single tree (the output).Ω is determined by the set of dependency labelsr ∈ R and one of...
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Báo cáo khoa học: Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase a-primase ppt

Báo cáo khoa học: Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase a-primase ppt

... replication is stimulated by NF-I in vivo but not in vitro support thisexplanation [50]. This view is consistent with the knowledgethat introducing an SV40 sequence into the JCV genomeFig. 4. SV40 and ... a-primase is at least in part involved whencompounded by other factors not present in our assays.This view is supported by the recent finding that the JCvirus receptor is widely distributed ... beforehand with a primase assay on poly (dT). Lanes1 and 2, control reaction with DNA polymerase a-primase lackingTAg or vice versa; lanes 3 and 4, 0.2 U and 0.4 U of human; lanes 5 and 6, 0.2 U and...
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Báo cáo khoa học:

Báo cáo khoa học: "A Model for Robust Processing of Spontaneous Speech by Integrating Viable Fragments*" ppt

... tactic, prosodic and pragmatic information as well as tense and aspect and sortal information. An ex- ample of a VIT for the sentence Montag ist gut ('Monday is fine') is given in (1). ... ponent in Verbmobil-2 is to collect these partial analyses and try to put them together on the basis of heuristic rules to produce deep linguistic analy- ses even if the input is not completely ... the WHG that can be assigned a complete and spanning syntactic- semantic analysis. This is mainly due to two factors: • spontaneous speech phenomena, and • speech recognition errors. However,...
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Báo cáo khoa học: The lipid translocase, ABCA4: seeing is believing Naomi Laura Pollock and Richard Callaghan ppt

Báo cáo khoa học: The lipid translocase, ABCA4: seeing is believing Naomi Laura Pollock and Richard Callaghan ppt

... significance it hasin the visual cycle is unclear. The investment in creat-ing the unique lipid composition of the OS discs, and the existence of other visual disorders caused by aber-rant lipid sorting ... [19,48], indicate that this is a criticalprocess to enable vision. As ABCA4 is localizedexclusively to this membrane, it is likely that its activ-ity is also influenced by the unique membrane ... fromthis region results in the loss of central vision that is characteristic of SD [24].Apical to the OSs of the PRCs is the retinal pigmentepithelium (RPE) (Fig. 1B). It is underpinned by abasement...
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Báo cáo khóa học: Fidelity of targeting to chloroplasts is not affected by removal of the phosphorylation site from the transit peptide doc

Báo cáo khóa học: Fidelity of targeting to chloroplasts is not affected by removal of the phosphorylation site from the transit peptide doc

... material by biolistic transformation, and the location of GFP fluorescence was determined by confocal microscopy as described [19].Results Generation of fusion constructs and mutagenesisof the ... phosphorylation motif described by Waegeman and Soll [13]. (B) The transit peptides of tobacco and pea SSU and ArabidopsisCtRS and HtRS, with the phosphorylation motif underlined and the predicted site ... radio-labelled precursors were incubated with isolated pea chlo-roplasts, followed by reisolation of the organelles, and theproteins were analysed by SDS/PAGE and fluorography(Fig. 2). Figure 2A shows...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ