Báo cáo khoa học: "Search in the Lost Sense of “Query”: Question Formulation in Web Search Queries and its Temporal Change" pptx
Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... 20–564), and the model iscomposed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study areshown in Fig. 3. To elucidate the mechanism of the substrate ... of 3.2) [45] was a solution in the Dali result. It islikely that the inte rface between N-terminal and b-he licaldomains participate in binding of the polysaccharide,pullulan.Comparison of ... 372, and 373are the potential catalytic r esidues of I PU. Also, Trp425 of Dex49A, which is the corresponding residue of Trp402 of IPU, is reportedly located in the vicinity of the active siteand...
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Báo cáo khoa học: Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain pptx
... structures, the rest of bacitracin A as ‘Bacitracin A’, and all other amino acids not involved in the crosslink by the sin-gle-letter code. The PDI peptide side of the disulfide bond is named R1, and the ... of bacitracin on PDI that involves covalent binding of anopen thiol form of bacitracin to free cysteines in the substrate-binding domain of PDI. However, the inter-action between bacitracin and PDI ... rate of catalysis in the presence of bacitracin. These findings can be explained by ourresults showing that bacitracin targets the substrate-binding domain of PDI, but not the catalytic domain.Furthermore,...
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Báo cáo khoa học: Intrabodies against the EVH1 domain of Wiskott–Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells potx
... in the following combinations: 18SVH–linker and linker)18VL, 18VH–linker and linker)18VL, 21SVH–linker and linker)21VL, 21VH–linker and linker)21VL and single-chain antibodies, ... overexpressing the EVH1 domain. These results indicate that the EVH1 intrabodies inhibit only the EVH1 domain function that regu-lates IL-2 synthesis signaling without affecting the overall domain structure of ... intrabodies synthes-ized in the ER are released from the ER membraneinto the cytosol by retro-translocation in lymphocytesincluding T cells [25]. In general, when proteins synthesized in the...
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Báo cáo khóa học: Acharan sulfate, the new glycosaminoglycan fromAchatina fulica Bowdich 1822 Structural heterogeneity, metabolic labeling and localization in the body, mucus and the organic shell matrix docx
... belocated in the body of this species using alcian blue staining and it was suggested to be the main constituent of the mucus. In the present work, we provide further information on the structure and ... of them. The finding of Achatina fulica in the area may berelated to its commercialization as a food item [15]. The giant African snail is considered a major pest in many parts of the world and ... volumes of sodiumacetate buffer (pH 5.5) containing 40 mg papain in the presence of 5 mMEDTA and 5 mMcysteine, and incubatedat 60 °C for 24 h. GAGs were isolated and purified from the papain-digested...
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Tài liệu Báo cáo khoa học: "Methods for the Qualitative Evaluation of Lexical Association Measures" doc
... to the recall curves (Figures 3 and 4), we find: (i) Examination of 50% of the data in the SLs leads to identification of between 75%(AdjN) and 80% (PNV) of the TPs. (ii) For the first 40% of the ... mixed;(ii) the grammatical status of the individual wordcombinations in the base set, i.e., whether theyare part of or constitute a phrase or simply co-occur within a given text window; (iii) the ... outper-formed by the t-test afterwards. Looking at the first 40% of the data, there is a big gap between the good measures (t-test, log-likelihood, and fre-quency) and the weak measures ( and ). In the second...
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Báo cáo khóa học: Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy pptx
... is the ÔcoreÕ of the CaM-binding site of the enzyme[9,16–21]. The mechanism of AC activation by CaM, and in particular the role of the conformational change resultingfrom CaM binding, remains ... couplingFig. 5. Binding of Ant-dATP to AC (d) and AC–CaM (m). The degree of binding of the ligand was calculated from the value of the ampli-tude of the long lifetime, which characterizes the ... of the CaM-binding domain probed by W242W242 dominates the intrinsic fluorescence emission of the protein [20]. It is situated in the middle of the 72-amino-acidsegment responsible for 90% of...
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Báo cáo khoa học: "A Chain-starting Classifier of Definite NPs in Spanish" docx
... arearound the eighties, and around the seventies in the case of Vieira and Poesio (2000), who use the Penn Treebank.Luo et al. (2004) make use of both a linking and a starting probability in their ... chainstarting.5. If m is a simple definite,(a) and the head of m appears in the list of storageunits, classify as chain starting.(b) and the head of m is AP-preference, classify aschain ... resolution, but the startingprobability happens to be the complementary of the linking one. The chain-starting classifier webuild can be used to fine-tune the starting probabil-ity used in the construction...
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Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
... to examine how the second kinase in the cascade determines the time dependence of the activity of the third kinase, we varied the Vmax of the secondkinase reaction and recalculated the concentration ... strength; the dur-ation of the signal; the final signal strength and the integral signal strength. The summing is over all the processes in the system, and its results are given in the final column of ... duration and integral signal strength. Of course, these findings can be no more than sugges-tions, as they were obtained for a certain set of kineticparameters and a certain type of kinetics of the...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... the sequences of 1CEV and 1RLA and pasted into the structural alignment. The alignment was then corrected byhand. Since the sequences of the two arginases and agmatinase greately differ in the ... agmatinase with the GfiAandCfiT substi-tutions in the coding and noncoding strands, respectively, and using the 5¢ and 3¢ primers mentioned above, the fulllength agmatinase cDNA coding for the ... agmatine to putrescine and urea [1].Agmatine, which results from decarboxylation of arginineby arginine decarboxylase [2], is a metabolic intermediate in the biosynthesis of putrescine and higher...
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Tài liệu Báo cáo khoa học: Evidence that the assembly of the yeast cytochrome bc1 complex involves the formation of a large core structure in the inner mitochondrial membrane pdf
... repre-sent the last subunits incorporated into the bc1com-plex. On the other hand, the absence of Qcr9p in the DQCR9 ⁄ DQCR10 strain prevented the binding of ISP(Fig. 4B). Interestingly, in the ... addition of ISP and Qcr10p).On the other hand, in the transition from the 500 kDaband to the 670 kDa band, a structural rearrangement of the bc1complex may occur due to the binding of ISP and ... specificallyrequired for the insertion of ISP into an immature bc1complex and that the association of the Qcr9p subunitwith the bc1complex precedes the binding of ISP. In fact, the direct absence of ISP (DISP),...
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Từ khóa: Nghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM