... Quercetindid not inhibit ROS generation, and enhanced cytotoxicity of Topotecan in both cells. In contrast, NAC enhanced resistanceagainst doxorubicine and vincristine in MRP1 overexpressingcells. ... perplexing diversity of lesions is continuously induced in our genes ranging from sin-gle and double strand breaks, to chemical alterations of nucleo-tides including adducts, as well as inter- ... activation of JNK, serineAbstracts19phosphorylation of insulin receptor substrate 1 (IRS1), andinhibition of insulin action. Hence, we conclude that JNK acti-vation and ER stress, integrates in ammatory...