Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... control in Alzheimer’s disease X. Li et al.4220 FEBS Journal 272 (2005) 4211–4220 ª 2005 FEBS Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease ... correla-tion with tau nonphosphorylated at Tau1 sites.Total and phosphorylated levels of eEF2K and eEF2 in AD and control brains Levels of p-eEF2K were significantly increased( 40%) in AD brains, as ... 4E-BP1, eEF2, and eEF2Kwere investigated in relationship with tau in homogen-ates of the medial temporal cortex from 20 AD and 10control brains.Results Levels of total and phosphorylated mTOR in...
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Tài liệu Báo cáo khoa học: Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis pdf
... signal-regulated kinase; JKAP, c-JUN N-terminal kinase pathway-associatedphosphatase; JNK, c-JUN N-terminal kinase; JSP, c-JUN N-terminal kinase stimulatory phosphatase; JSP1-CS, inactive mutant of JSP1(active ... [37].Myristoylation can also in uence the movement and final destination of a signaling protein within thecell. We observed that myristoylation of JSP1 deter-mined its localization to distinct sites in the cyto-plasm. ... create stable cell lines expressingJSP1-wt constitutively, and almost all of the existingcell lines we have examined do not express detectable levels of JSP1 protein. In fact, in order to generate...
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Tài liệu Báo cáo khoa học: Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae pptx
... pheromonesto elicit a mating response in cells of the oppositemating type. Cdc42 is involved in pheromone signal-ling that eventually results in G1arrest and the for-mation of a mating projection ... formation of a matingprojection [28]. Furthermore, homologues of oxysterol-binding proteins, a family of proteins that regulatethe synthesis and transport of sterols, were found toparticipate in ... morphology of the strains used in this study. (A) Morphology of deletionstrains. The indicated strains were grown in YPD to stationary phase. The cells werethen fixed with formaldehyde and examinedby...
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Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx
... Analysis of two CBP(cAMP-response-element-binding protein-bindingprotein) interacting sites in GRIP1 (glucocorticoidreceptor-interacting protein), and their importance forthe function of GRIP1. ... conforma-tional change of GRIP1 might have resulted frominter- and intramolecular interactions within its C-ter-minal and other regions. Hence, the modulation of GRIP1 transactivation and co-activation ... related proteins, and possibly by acety-lating or methylating histones or other proteinsinvolved in the transcription machinery [5,10,19–21].Two separate domains of p160 co-activators can bindto...
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Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
... Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involve-ment of RNase L, protein kinase R, and alternativepathways. ... and stimulate innate and adaptive immune responses [1–3].Among the kinases activated are mitogen-activatedprotein kinase, Jun-N-terminal kinase (JNK) and p38,which phosphorylate AP-1 [4,5], IjB kinase ... converting l-arginine into l-ornithine and urea, a critical step in the polyamine biosynthesis path-way. Subcellular localization of the two isoforms dif-fers, with ArgI located in the cytoplasm and...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... biochemicalactions of sphingolipid-derived messengers such as S1P weremediated through various protein kinase and monomericGTP-binding protein signaling pathways including MAPkinases and Rho GTPases ... were treated with specificinhibitors for either protein kinase C, PI 3 -kinase or p42/p44MAP kinase. Similarly, a specific protein kinase A (PKA)Fig. 6. Selective inhibition of S1P-induced Cyr61/CCN1 ... extracellular-regulated kinase 1/2(ERK1/2), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein (MAP) kinase and nonreceptor tyrosinekinases [19,20]. These signaling pathways are linked totranscription...
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Báo cáo khoa học: Photoregulation of DNA transcription by using photoresponsive T7 promoters and clarification of its mechanism doc
... clarification of its mechanismXingguo Liang1, Ryuji Wakuda1, Kenta Fujioka1 and Hiroyuki Asanuma1,21 Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya ... transcription of the GFP gene initiated by the photoresponsive T7 pro-moter involving two Azos.Fig. S3. Direct observation of differences in bindingaffinity between the trans–trans and cis–cis forms usingsurface ... that of Azo [30]. Thus,a photoresponsive T7 promoter involving DM-azo haspromise either in vivo or in vitro for clear-cut photos-witching at a wide range of temperatures and timeintervals.Kinetic...
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Báo cáo khoa học: Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms pot
... dependingon TPT1 promoter sequences or TCTP mRNA 5¢⁄3¢-UTRs and investiga-tion of the interaction of RNA-binding proteins with UTRs by UV-cross-linking. PMA, forskolin, dioxin, cobalt and nickel ... transcription with actinomy-cin D and followed the kinetics of TCTP mRNAdecay (Fig. 6). Interestingly, inhibition of transcriptionby actinomycin D treatment did not accelerate mRNAdecay as expected; instead, ... cobalt and nickel act via inhi-bition of TCTP mRNA decay, and that this is associ-ated with differences in the interaction of cytosolicproteins with the TCTP mRNA 5¢-UTR and 3¢-UTR.Dioxin induced...
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Báo cáo khoa học: Binding of berberine to human telomeric quadruplex – spectroscopic, calorimetric and molecular modeling studies pot
... FEBSinteraction of berberine with quadruplex. The occur-rence of sharp isobestic points at 359, 383 and 445 nmclearly indicates the existence of equilibrium in thebinding. Ligand binding with ... limits the interaction to a single binding mode.It was seen that addition of increasing concentrations of quadruplex results in a gradual increase in thefluorescence intensity of berberine, indicating ... (34–40%) in the k341 nm of berberine. The red shift in the absorp-tion maxima and the observed hypochromicity of ber-berine in the presence of quadruplex may beinterpreted in terms of stacking interactions...
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Báo cáo khoa học: Inactivation of tyrosine phenol-lyase by Pictet–Spengler reaction and alleviation by T15A mutation on intertwined N-terminal arm docx
... view of red-lined box in overall structure. Green linesrepresent intimate molecular interactionsincluding hydrogen bond networks in vicinity of Thr15 on intertwined N-terminal arm.H-bond information ... assay solution, and examined for their remaining activity using 1 mml-tyrosine as the substrate. The remaining activity of the mutant and native enzymes decreased according tothe incubation time, ... ethanol and 15 units of enzyme.The reaction bottle was flushed with nitrogen gas, tightly sealed with a rubber stopper, and incubated at 45 °C. Samples were with- drawn using a syringe in a stream of...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ