Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc
... Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser21 ... that mitochondria contribute to the induction of oxidative stress during ischemia ⁄ reperfusion in brain. There is a growing body of information concerning the mechanism of ROS generation by the ... open-ing of the mPTP. There is evidence that ADP inhibitsopening of the mPTP by occupying binding siteslocated in the inner and outer mitochondrial mem-brane [39,40]. The binding of ADP stabilizes...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... relative to the level of wild-type tobacco, taken as 1,referring to the transcripts of CAT1 in the same samples. (C) The total activities of the antioxidant enzymes SOD, CAT and APX in the tobacco ... species scavenging capability and oxidative stress tolerance. These results increased our understanding of the role of the group C GhMPK2 gene in multiple defense-signaling pathways,including those ... partlyblocked by the addition of Ag+. These results suggestthat GhMPK2 might be involved in the oxidative stress response and in the JA ⁄ ET signaling pathway.Overexpression of GhMPK2 in tobacco plantsimproved...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... nitrate and H2O2,are normally produced in the brain. H2O2 is convertedinto water by catalase and glutathione peroxidase,which involves GSH, a cofactor of this enzyme [5,8].GSH is one of the ... related to the mechanisms involved in the initiation and ⁄ or propagation of seizures induced by pilocarpine. Our results are in agreement with another study showing unalteredsuperoxide dismutase ... 1307inefficiency of the electron-carrying components of the mitochondrial transport chain, monoamine degradation,xanthine oxidase reaction, and metabolism of arachidon-ic acid. However, the...
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Báo cáo khoa học: Oxidative stress induces a reversible flux of cysteine from tissues to blood in vivo in the rat pptx
... of biosynthesis and sites of utilization. Little is known about the effect of oxidative stress on the distribution of low- molecular-mass thiols and their exchange rate between tissues. In this ... key role in defense against oxidative stress. The availability of GSH is ensured in tissues by systems devoted to its mainte-nance in the reduced state and by the flux of GSH and cysteine betweensites ... little is known about the in uence of oxidative stress on cysteine and glutathioneexchange among tissues. Indeed, the factors that main-tain the redox homeostasis of plasma thiols as well asthe...
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Báo cáo khoa học: Oxidative stress and apoptotic events during thermal stress in the symbiotic sea anemone, Anemonia viridis potx
... [7,52,57].Nevertheless, independently of the resulting effect of the thermal stress, all mechanisms point to the involve-ment of oxidative stress in the early stages of symbiosisbreakdown. In fact, ... be involved in necrosis or in so-called postmitochondrialphase of apoptosis [26]; or (b) they could be involved in the initiation phase of apoptosis contributing to celldeath signaling [27].Programmed ... animal tissue of A. viridis The occurrence of oxidative stress in the animal tissue(ectoderm and gastroderm) and freshly isolated zoox-anthellae of A. viridis was monitored during heat stress (+8...
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Tài liệu Báo cáo khoa học: "THERE STILL IS GOLD IN THE DATABASE MINE" potx
... the Michigan doctors and Pennsylvania dentists, produced a list of all the people who were either doctors or dentists and who lived in either Michigan or Pennsylvania. This is the state of ... databasesl" has resulted in this panel, which is supposed to debate the necessity of continuing work in this area rather than to debate technical issues in the area. And yet if this problem has been ... ambiguity (the word "yield" is ambiguous if there is both financial and productivity data in the knowledge base), and other complex linguistic phenomena. Let us go on to define the other...
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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... differences in function or localization of these isoforms in the brain. In order to try to understand how these isoforms may differ, we exam-ined the expression of the isoforms known to be tran-scribed ... reported in fetal liver and brain [2], butno isoforms containing exon 3 have yet been described. The RCAN1 protein is able to bind to and inhibit the catalytic subunit of calcineurin (protein phosphatase ... the ser-ine–threonine protein phosphatase calcineurin [5]. The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is highly expressed in this organ,...
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Báo cáo khoa học: P-Glycoprotein is localized in intermediate-density membrane microdomains distinct from classical lipid rafts and caveolar domains potx
... entirely in the Brij-96-insoluble domains, and only partially in the Triton X-100-insoluble membrane microdomains. We studied the sensitivity of these domains to cholesterol removal, as well as their ... on the fact that Triton X-100 rafts are most often isolated using a1% concentration, and the upper limit of the solubility of Brij-96 at 4 °C is 0.5%. Each lysis buffer contained the following ... removal on GM1 and caveolin-1 distribution was far more profound in the Triton X-100 rafts than in the Brij-96 rafts. The GM1- and caveolin-1-containing domains not onlyshowed a shift to higher...
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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in fishes doc
... which, in turn, regulate the expression of genes involved in osmotic stress acclima-tion. In addition to intracellular signaling mechanisms, the systemicresponse to osmotic stress in euryhaline ... [21] and in the closing or opening of apical crypts of gill chloride cells[22]. Furthermore, changes in ion transport duringhyper- and hypotonic stress require intact F-actin and microtubules in ... are involved in osmotic stress signaling [18]. Anotherosmoregulatory hormone, angiotensin II, increases freeintracellular calcium in fish tissues [19], confirming that the effects of osmoregulatory...
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Tài liệu Báo cáo khoa học: Human Cdc45 is a proliferation-associated antigen pdf
... for 30 min with preformed macromolecularcomplex consisting of avidin and biotinylated peroxidase(Vector Laboratories, Burlingame, CA), which retainsbiotin-binding sites. The staining reaction ... culturing them up to passage26 or 28. Intracellularly, senescence was exerted and maintained through the function of the cyclin-kinaseinhibitors p21CIP1 and p16INK4A[32]. In agreementwith the ... cyclin-dependent kinases and Cdc7 kinase[10]. Following activation of these kinases, replicationfactors such as Cdc45, GINS and Mcm10 are recruited to the origins [11]. Cdc45 has a critical role in the Keywordshalf...
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