Báo cáo khoa học: " The Signal System in Interlingua — A Factor in Mechanical Translation" potx

... researcher in mechanical translation as amounting to the elabo- Signal System in Interlingua 57 ration of a system whereby all the elements ap- pearing in the finished translation are unambigu- ... the signal systems of the departure language and the target language. In other words In a given pair of languages that are to be inter- related by the process of mechanical translation, the ... translation and of mechanical translation in particular is not that the signal system of departure language and target language be complete in any absolute sense of the term but rather that...

Báo cáo khoa học: "THE CONTRIBUTION OF PARSING TO PROSODIC PHRASING IN AN EXPERIMENTAL TEXT-TO-SPEECH SYSTEM" doc

... integrate the material in the comptemennzer Wltla the material in the core sentence as they are analy.zing the material in the core bentence or after that analysis IS completed. If they integrate ... contrast, a finer treatment of local syntactic constraints on boundary values preceding final constituents is within reach. From the data we have examined, it appears that the character of the prosodic ... groups, all right- adjoining: on each, in 48-channel, can power, the echo, that are and in that. These groups of adjoined words appear as terminals in the prosody tree in Figure 2. In subsequent...

Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt

... participates in picolinicacid (PA), quinolinic acid (QA) and NAD homeostasis. Indeed, the enzymestands at a branch point of the tryptophan to NAD pathway, and deter-mines the ﬁnal fate of the amino acid, ... related by a dyad axis in the crystal, and a mixture of monomeric and dimeric forms in solution[18]. Therefore, the available structural data suggestthat the minimal functional unit in the ACMSDenzyme ... ultimatelycontrols the metabolic fate of tryptophan catabolismalong the kynurenine pathway, and is a medically rele-vant enzyme in light of the important roles played byQA and PA in physiological and pathological...

Tài liệu Báo cáo khoa học: The chitinolytic system of Lactococcus lactis ssp. lactis comprises a nonprocessive chitinase and a chitin-binding protein that promotes the degradation of a- and b-chitin doc

... dominant polymorph a- chitin (antiparallel packing of the chitin chains);b-chitin (parallel packing of the chitin chains); and the minor polymorph c-chitin (mixture of parallel andantiparallel ... complemen-tary strategies to gain access to and degrade individualpolymer chains. First, the chains are degraded by bothendochitinases, that attack the chitin chain randomly,and exochitinases, that attack ... suppliers’ instructions, containingends compatible with the expression vector (forwardprimer, 5¢-GGTATTGAGGGTCGCCATGGTTATGTTCAATCACCA-3¢; reverse primer, 5¢-AGAGGAGAGTTAGAGCCTTACAAGAAGGGTCCAAAGA-3¢)....

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... (for a fraction ‡ 90%), the apo-L8 5A isapproximately 75% dimeric, whereas the apo-L27 6A and the apo-L8 5A ⁄ L8 5A mutants are in the mono-meric state. The association state of the holoenzymescan ... to weaken their interaction with the N-terminal a- helix. This can be imagined to be the main cause of subunit dissociation in apo-eSHMT. At the same time, the mutations may indirectly alter the structure ... complexes. A single subunitfolds into two domains [6]. The central feature of the N-terminal, larger domain is a seven-stranded b-sheet. In some instances, the N-terminal tail does not partici-pate as...

Báo cáo khoa học: The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme–substrate complex ppt

... Geneservices(Cambridge, UK) using the primers 5¢-GTCTTCGAA A CCATGGAGAATCAAGAGAAGGCGAGTATCGCGGG-3¢ and 5¢-GAGAGCTCGAGAACAGAACTTCAAGACCGTGGCAGGAGC-3¢. The NcoI and Xho I sites used forfurther cloning are ... equation using nonlinear least-squares analysisincorporated into the origin software package (OriginLabCorp., Northampton, MA, USA), and the maximal cata-lytic centre activity (kcat) and the ... m)1Æcm)1[29], and using a Varian Cary 50 Bio spectrophotometer (Varian Inc., PaloAlto, CA, USA). The concentration of benzylamine wastypically in the range 0.02–2 m m, and the assay was startedby the addition...

Báo cáo khoa học: The hinge region operates as a stability switch in cGMP-dependent protein kinase Ia doc

... release of the auto-inhibitory domain from the active site, thereby activa-ting the kinase. This is indicated by a remarkableincrease in the proteolytic sensitivity of the N-terminus in the ... 1–77(9128.3 ± 0.7 Da), as depicted in the inset of Fig. 4.These N-terminal fragments all conﬁrmed the above-stated N-terminal acetylation and elimination of the ﬁrst methionine amino acid. At the retention ... domain interactions in presence andabsence of cGMP. The interaction of the auto-inhibi-tory domain with the catalytic domain in the presenceand absence of cGMP is of particular interest, as itforms...

Báo cáo khoa học: The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme’s stability and conformational transitions linked to Na+ binding pdf

... and B-chains In WT thrombin, the A- chain assumes an overallboomerang-like shape interacting with the B-chain sur-face opposite to the active site [17]. Stabilization within the A- chain and between ... perturbed intra- and interchainbonds.After 180 min denaturation with 6 m urea and0.2 mm b-mercaptoethanol, the A- chain was releasedand the the native enzyme form disappeared for bothWT and mutant ... mutant than in WT thrombin. Applica-tion of the Brønsted theory on acid ⁄ base-catalyzedreactions indicated that in the thrombin amidase cycle the His57 imidazolium form acts as a general acid...

Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

... not menadione, provokes a decrease in the ATPand an increase in the inosine levels in Saccharomyces cerevisiaeAn experimental and theoretical approachHugo Osorio1,2, Elisabete Carvalho1, ... concom-itant appearance of inosine (Fig. 1A) . Incubation timeslonger than 30 min in the presence of H2O2did not greatlychange the ratio SATP + ADP + AMP/Ino. Similarchanges in ATP and inosine ... – mathematical simulation of somemetabolic pathways related to adenine nucleotide meta-bolism. This was a theoretical approach. The simulationwas started by stating the metabolic pathways...

Báo cáo khoa học: "THE TEXT SYSTEM FOR NATURAL LANGUAGE GENERATION" doc

... of the schemas, providing constraints on what can be said at any point. These mechanisms have been implemented as part of a generation method within the context of a natural language database ... of system (such as a tutorial system, for example). The semantics are not particular, however, to the domain of the database. When transferring the system from one database to another, the ... described in more detail after setting out the framework of the system. 2.0 APPLICATION In order to test generation principles, the TEXT system was developed as part of a natural language interface...

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