... Cohen’sdiscovery of the ‘tooth-lid factor’ led to the identifica-tion of the genetic causes of certain types of humancancers, and to the genetic classification of a variety of tumors of apparently the same ... regula-tory domain. These provide docking sites for downstream molecules and lead to the evasion of apoptosis, to proliferation, to invasion and to metas-tases, all of which are important for the ... the control of doxycyclin [22,23].Expression of either EGFR mutant led to the develop-ment of adenocarcinomas similar to human BACs, and the withdrawal of doxycycline to reduce expression of the...