Báo cáo khoa học: The importance of being dimeric pptx

... via a dimeric intermediate. Biochemistry 39,11667–11676.G. Mei et al. The importance of being dimeric FEBS Journal 272 (2005) 16–27 ª 2004 FEBS 27REVIEW ARTICLE The importance of being dimeric Giampiero ... (d) and dimeric (s) proteins as a function of the total number of amino acids. The importance of being dimeric G. Mei et al.18 FEBS Journal 272 (2005) 16–27 ª 2004 FEBSTable 1. List of dimeric ... linear trend of the DG values vs.their size. The importance of being dimeric G. Mei et al.20 FEBS Journal 272 (2005) 16–27 ª 2004 FEBSsmall proteins of class A (Fig. 4A, dashed area). The crystallographic...

Báo cáo khoa học: The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts doc

... Department of Health Risk Analysis and Toxicology, Maastricht University, the NetherlandsColorectal cancer is the third most commonly diagnosedcancer in the world and is one of the major causes of cancer-associated ... absorbed in the intestinal tract, and reach the colon mainly intact [27]. They are therefore bio-available to the epithelial cells in the intestinal wall,where procyanidins and other phenolics ... investigated the relationship of different structural factors of procyanidins, such as the mean degree of polymerization and percentage of galloylation, with their antiproliferative potential andtheir...

Báo cáo khoa học: "The Importance of Rule Restrictions in CCG" doc

... grammarGTthat generates the yields of the set of all transformed derivations of G.As the set of terminals of GT, we use the set of terminals of G. To form the set of nonterminals, wetake ... happens to the proof of The- orem 1 in the context of pureB&K-CCG. Thereis only one point in the entire proof that could bedamaged by the introduction of slash types, andthat is the result ... categoryjy,plus the arguments of x. We number the arguments of a category from outermost to innermost. The arity of a category is the number of its arguments. The target of a category c is the atomic...

Tài liệu Báo cáo khoa học: The occurrence of hemocyanin in Hexapoda docx

... possible ‘intermediate’. The evolution of hemocyanin subunits follows the widely accepted phylogeny of the Hexapoda and provides strong evidencefor the monophyly of the Polyneoptera (Plecoptera, ... On the tracheal system of Collembo-la, with special reference to that of Sminthurus viridis,Lubb. Q J Microsc Sci 71, 15–30.39 Williams CB (1913) A summary of the present knowl-edge of the ... with genedoc 2.7 [41]. The tools provided with the ExPASy Molecular BiologyServer of the Swiss Institute of Bioinformatics (http://www.expasy.org) were used for the analyses of DNA andamino acid...

Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf

... decrease in the amount of precipitation in the presence of high concentrations of Arg-HClin the absence of the chaperone precluded analysis of the effect of this concentration on the protectiveability ... pre-cluding analysis of the effect of these concentrationson the chaperone activity of aB-crystallin (Fig. 4B,C).None of the compounds had an effect on the morphol-ogy of the amyloid ﬁbrils ... calculated from the standard errorsassociated with the means of the measured values (i.e. bycalculating the square root of the sum of the associatedindividual errors squared). The maximum percentage...

Tài liệu Báo cáo khoa học: The sequentiallity of nucleosomes in the 30 nm chromatin ﬁbre pptx

... amount of dinucleosomes, as well as the grad-ual decrease of the number of nucleosomes in the mainpeak, indicates that crosslinking is almost complete in the middle of the fibre, but some of the ... Indeed, there is evidence that the tails of thesehistones follow the path of the linker DNA [5]. Theyare crosslinked first to each other first and subse-quently to the core histones [19]. The even ... in which the presence of linker his-tone is questionable. Furthermore, the presence of alloligomers, with dimers up to the half the size of the original samples after digestion of the linkers,...

Tài liệu Báo cáo khoa học: The stereochemistry of benzo[a]pyrene-2¢-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases pptx

... accordance with this, the depend-ence of the ﬂuorescence of the (+)-trans adduct on itsposition relative to the target dC was revealed in the case of the formation of the complexes of M.SssIwith ... with the intercalativeconformation of the (+)-cis adduct and the minor-groove conformation of the (+)-trans adduct, the lat-ter interfering with interactions of the catalytic loops of the MTases ... of the DNA double helix into the M.HhaI active-sitepocket [45]. The ﬂipped out cytosine forms contactswith the catalytic loop of the enzyme from the DNAminor-groove side. The contacts of the...

Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx

... role for components of the ER–Golgi vesicle transport. Through the use of mark-ers for the ER (PDI) and the Golgi apparatus(GM130, p230), the phosphorylated isoforms of the K650M mutant were ... FEBSother mutants (Fig. 1C). The 130 kDa isoform of the K650M mutant was only weakly and variably detectedin immunoblots. Scanning densitometry of the gel fur-ther indicated that the intensity of ... prevented by blocking transport from the ER to the Golgi. BFA had no effect on the relativelack of the 130 kDa isoform of the K650M mutant.Endo H digestion of the immunoprecipitated wild-typeand Y373C...

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... center of the membrane(Fig. 4);(b) the major axis of the dimeric RNase was made coinci-dent with the z axis of the system, hence orthogonal to the membrane plane (Fig. 4);(c) the dimeric ... N-terminal structural regions,respectively, of the two A and B monomers of the dimeric RNase. The black circle between the monomers indicates the mass center of the dimer.E. Notomista et al. Electrostatic ... EIEmaxvalues. As a measure of the RNase cytotoxicity we used the reciprocal of the IC50parameter. The values of IC50, the RNase concen-tration at which 50% of the cytotoxic effect is dis-played,...

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... fusion with the membrane of intra-endosomal vesicles contained within MVBs,thereby releasing the nucleocapsid into the lumen of these vesi-cles. Then, the capsid uses these intra-endosomal vesicles ... which leads to the generation of recombino-genic intermediates. DNA recombination enables the cells tocross the mitotic boundary, but the damage that remains kills the cells during the subsequent ... Thus, in the absence of recombination, the cells become hypersensitive to killing bymethylating agents and arrest already in the ﬁrst G2. We arecurrently searching for the structures of the recombination...

Xem thêm