Báo cáo khóa học: Phospholipase C, protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells ppt
Báo cáo khóa học: Phospholipase C, protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells ppt
... 2004 Phospholipase C, protein kinase C, Ca 2+ /calmodulin-dependent protein kinase II, and redox state are involved in epigallocatechin gallate-induced phospholipase D activation in human astroglioma cells Shi ... 2004).Abbreviations: CaM ki nase II, Ca 2+ /calmodulin-dependent protein kinase II; DCFH, 2 ¢,7¢-dichlorofluorescein diacetate; DCF, 2¢,7¢-dichlorofluorescein; DMEM, Dulbecco’s modified Eagle’s m edium;EC, epicatechin; ... 3475 activation is dependent on Ca 2+ and possibly involves the Ca 2+ -activated protein kinase, CaM kinase II.Involvement of PKC in EGCG-induced PLD activation Phosphoinositide-specific PLC activation...
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Tài liệu Báo cáo khoa học: Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects doc
... occurring mainly within domain III ofETA-A. Cell-free endosomes preloaded in vivo with ETA intraluminallyprocessed and extraluminally released intact ETA and ETA-A in vitro in apH-dependent and ... [22].The antibody against KX5KDEL also binds to undefined endosomalproteins distinct from ETA, both in control and in toxin-injected rats,whose levels have been shown to be modified by toxin treatment[22]. ... acid proteasecathepsin D, as indicated by the following observa-tions: (a) the inhibitor profile of the endosomalETA-degrading activity was very similar to that ofcathepsins B and D [30]; and...
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Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt
... unknown.Binding of cGMP during deactivation of PabcNext, we investigated whether cGMP binds to Pabcduring deactivation of Pabc to Pabcc. Binding ofcGMP may be involved in Pabc deactivation in twoways: ... change is indeed involved in PDEregulation.Suppression of cGMP binding during activation of PabccTwo possible stages for cGMP binding to Pabc are expected in PDE regulation: during Pabcc activation to ... toGAF domains in amphibian rod photoreceptor cGMPphosphodiesterase (PDE). Identification of GAFdomains in PDE alphabeta subunits and distinctdomains in the PDE gamma subunit involved in stimu-lation...
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Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc
... byFernandez-Recio and coworkers [30] as integrated in themodeling packageICM(Molsoft LLC, San Diego, CA, USA). This first protocol included a pseudo-Brownianrigid-body docking, an extended force ... constantsobtained by fitting all time courses to the random-ordercleavage model as described in Materials and methods,under the constraints that k306is minimally in uenced byheparin and using k¢306obtained ... calculated as described in Materials and methods.Ó FEBS 2004 Heparin and APC-catalyzed inactivation of FVa (Eur. J. Biochem. 271) 2727FVaLeideninactivation in the absence and presence ofheparin....
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Tài liệu Báo cáo khoa học: Novel aggregate formation of a frame-shift mutant protein of tissue-nonspecific alkaline phosphatase is ascribed to three cysteine residues in the C-terminal extension pdf
... (1559delT) were replaced with serines, the aggregation disappeared and instead this modified mutant protein formed a noncovalently associ-ated dimer, strongly indicating that these cysteine residues ... medium and the rest was polyubiquitinated,followed by degradation in the proteasome. SDS ⁄ PAGE and analysis bysucrose-density-gradient analysis indicated that TNSALP (1559delT) formsa disulfide-bonded ... (antipain, aprotinin, chy-mostatin, elastatinal, leupeptin, pepstatin A) was added tocell lysates and media (10 lgÆmL)1for each). Unless statedotherwise, iodoacetoamide was not added to the...
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A pot
... jB-luc) in Jurkat cells by cAMP elevating agentsincluding FSK (A), db-cAMP (B), and Br-cAMP (C). (D) Inhibition of TNFa-induced HIV-LTR-luc activation in Jurkat cells by FSK and db-cAMP. (E and F) ... PKA, cAMP-dependent protein kinase; PKAc, catalytic subunit of PKA; FSK, forskolin;db-cAMP, dibutyryl cAMP; Br-cAMP, 8-Bromo-cAMP; CREB,cAMP response element binding protein; CBP, CREB binding ... the protein kinase A (PKA)-mediated phosphorylation oftranscription factors, including the cAMP response ele-ment binding protein (CREB) [9]. Interestingly, cAMPinhibits the induction of a distinct...
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Báo cáo khoa học: Retention of the duplicated cellular retinoic acid-binding protein 1 genes (crabp1a and crabp1b) in the zebrafish genome by subfunctionalization of tissue-specific expression doc
... reti-noids and steroids [1–3]. In mammals, two differentgroups of cellular retinoid-binding proteins with dis-tinctive binding properties have been identified, thecellular retinol-binding proteins ... (CRBPs) and the cel-lular retinoic acid-binding proteins (CRABPs). CRBPs,including CRBPI, CRBPII, CRBPIII and CRBPIV,show greatest binding affinity for retinol and retinal,but do not bind retinoic ... neurogenesis in both the devel-oping and adult CNS is the brain-type fatty acid bind-ing protein (B-FABP) gene [33–35]. In adult canary,B-FABP mRNA is distributed widely in the brain and is abundant in...
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Báo cáo khoa học: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways doc
... of dematincontaining 84 amino acids of the core domain and completeheadpiece domain mediated binding with the DH domain of human Ras-GRF2 (Fig. 1). In contrast, a bait constructcontaining ... N-ter minal PH domain, followed bythe coiled coil (cc) and IQ motifs, a single DH domain that isclosely linked to an other PH domain, REM and CDBmotifs, and a C-terminal Cdc25 exchanger domain ... most abundantly expressed in brain [5,6], wescreened a brain cDNA library prepared from adult human brain tissue to isolate cDNAs encoding for the dematin-interacting proteins. In the initial...
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Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt
... physiological and pathological roles beyondthrombosis and hemostasis in humans [10]. However, in rodents, including rats and mice, PCI is detected only in the testes and ovaries, and not in the liver ... serineproteases are involved, and its molecular targets mayinclude APC and thrombomodulin–thrombin [6], whichplay roles in the anticoagulant protein C pathway,thrombin and plasma kallikrein [7], which ... triggered by HGFA in the mouse model, and clinical data related to the regulation of HGFAby PCI in patients and normal individuals afterhepatectomy.PCI inhibits HGFA by formingHGFA–PCI independently...
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Báo cáo khoa học: Characterization of testis-specific serine–threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling doc
... b- D- thiogalactopyranoside; MBP, myelin basic protein; p70S6K, p70 ribosomal S6 kinase; PDK1, phosphoinositide-dependent protein kinase- 1; PKA, protein kinase A; PKB, protein kinase B; PKC, protein kinase C; ... sequencewithin the T-loop is also highly conserved in the Ca 2+ -and calmodulin-dependent protein kinase family(CaMK) to which TSSK3 is classified [1] and yetPDK1 does not phosphorylate CaMK kinases ... expression of mouse phosphoinositide-dependent protein kinase- 1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem 274,8117–8122.36 King CC, Gardiner EM, Zenke FT,...
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