... examined to determine the roles of these DHSs on the transcription of Ig-b gene and on the mainten-ance of the active chromatin state.ResultsGeneration of DT40/Cre cells with a long deletionin ... genes,and one in the downstream region of the GH gene.Transcriptional enhancing activity, as determined bytransient transfection, was associated with DHSs in the Na channel gene and in the first ... regionbetween the Ig-b and GH genes. A member of the OCT family transcription factors appeared to beinvolved in the transactivation of the region which had the highest enhancing activity of the three...