Báo cáo khoa học: Methylene analogues of adenosine 5¢-tetraphosphate Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases pot
... adenosine 5¢-tetraphosphate
Their chemical synthesis and recognition by human and plant
mononucleoside tetraphosphatases and dinucleoside
tetraphosphatases
Andrzej Guranowski
1
,El
_
zbieta Starzyn
´
ska
1
, ... pCH
2
pCH
2
pA.
Synthesis of adenosine- 5’-[a,b,b, c-bis (methylene) ]-
tetraphosphate, ppCH
2
pCH
2
pA.
Synthesis of adenosine- 5’-[a,b;c,d-...
... EA
D
is
off the reaction pathway responsible for the principal
transformation.
Values of K
SH
and k
f(H)
correspond to K
D
and k
f
for the
reaction of nondeuterated substrate, and K
SD
, k
f(D)
and
k
r(D)
are ... kinetics of quinonoid intermediate formation for the
reactions of TPL with
L
-phenylalanine,
L
-methionine, and
their a-deuterated analogs in D
2
O, and compare...
... presence of increasing concentrations of unlabeled Ggly. The
ApoTf–Ggly complex was separated from the unreacted Ggly by SDS ⁄ PAGE, and the extent of incorporation of radioactivity was determined
by ... of ferrous ions from the enterocyte by ferro-
portin and their oxidation to ferric ions by hephaes-
tin, circulating Gamide or Ggly might act as
chaperones for the upt...
... diagnostics and therapy, primarily because of
their relative ease of production by many systems,
including microbial culture. However, because of their
heterodimeric domain structure and weak heavy ... display
modes enables side -by- side evaluation of antigen-bind-
ing ability and V
H
⁄ V
L
interaction strength of the tar-
get Fv, and also rapid screening of Fv that...
...
(hundreds to thousands of words) and most lexical
information is not transportable across domains.
The problem of lexicon transport is worsened by
the growing degree of lexicalization of IE systems: ... ontology. This map-
ping between words and ontology is generally to
be built by hand. Most of the time in transport-
ing the lexicon is spent in identifying and buil...
... characterized by the ratio of
m
app
, determined by gel filtration chromatography, and the
absolute value of m, calculated from the amino acid
sequence of the protein.
NMR spectroscopy
1
H-NMR spectra of ... (2004) The role of structural
disorder in the function of RNA and protein chaper-
ones. FASEB J 18, 1169–1175.
28 Li SS (2005) Specificity and versatility of SH3 an...
... characteristic of molecular chaperones and shown here to be shared
by apoferritin and ferritin. This is the first report that apoferritin ⁄ ferritin
may protect cells from stress other than by iron sequestration. ... vitro,a
capability shared by apoferritin and ferritin, and con-
fers stress tolerance on transfected mammalian cells.
Artemin and ferritin may have arisen from t...
... relative
volume of a protein occupied by aliphatic side chain. On the
other hand, Bt-Lon is characterized by a higher content of
V (56 vs. 48), P (33 vs. 28), and E (84 vs. 76) and by a lower
content of G ... promoter region of Bt-lon. Potential )35 and )10 regions and the RBS are underlined. The )16 region is bold underlined. An
inverted repeat of dyad symmetry is box...
... characterized
by featu res of both A and BDNA. Possible implications
of this on the topological restrictions of 2¢,5¢ DNA, and
its rejection by nature, are discussed.
Materials and methods
DNA synthesis and ... uanti-
tation of anomeric effect in adenosine and guanosine by
comparison of th e thermodynam ics of the p seudorotational
equilibrium of the pentofura...
... 2,3-dioxygenase
and production of quinolinic acid by human
microglia, astrocytes, and neurons. Glia 49,
15–23.
3 Guillemin GJ, Wang L & Brew BJ (2005) Quinolinic
acid selectively induces apoptosis of human ... formation of NO• by the activation of nNOS. Highly reactive free
radicals are formed, which can cause oxidative damage to DNA lead-
ing to over-activation of P...