Báo cáo khoa học: a-Conotoxin analogs with additional positive charge show increased selectivity towards Torpedo californicaand some neuronal subtypes of nicotinic acetylcholine receptors pdf

... results show that introduction of a positive charge to the C-terminus of a-conotoxins givesnew analogs of distinct selectivity whose mode of action, with the purpose of future design of novelantagonists, ... Novel a-conotoxin analogs FEBS Journal 273 (2006) 4470–4481 ª 2006 The Authors Journal compilation ª 2006 FEBS 4481 a-Conotoxin analogs with additional positive charge show increased selectivity towards ... series of a-conotoxins with correctly closed disulﬁdes.Binding of synthesized a-conotoxin analogs tomembrane-bound Torpedo nAChRThe activity of analogs was evaluated in competition with radioiodinated...

Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx

... Cd1methyl of the Ile50 sidechain forms C-HÆÆÆO interactions with the hydroxyloxygen of Thr80¢ and carbonyl oxygen of Pro79¢, andthe Cd1 of Ile50¢ interacts with the hydroxyl of Thr80.Mutation ... These lines of evidence, taken together, strengthen the suggestion thatloss of the C-HÆÆÆO interaction of residue 50 with thehydroxyl of Thr80, as well as loss of hydrophobic con-tacts with inhibitor, ... APVshowed subnanomolar inhibition with a Ki of 0.16 nmfor PRWTand PRL90M.PRI54Mand PRI54Vshowedmodestly increased (three-fold) relative Kivalues. Thelargest increases in Kiof...

Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx

... mutants showeda very different dependence on l-dopa as cofactor toeliminate the characteristic lag period of tyrosinases[8,20,21]. Figure 3 shows the rate of TH activity as afunction of the ... copper-binding histidines of the twoPPOs do not show any differences (Table 1), but some distinctions must exist. The most reliable way of exploring this is comparison of crystal structure data.The ... location of melanizationseems to be essential for the prevalence of one of thesetwo opposing processes. In any case, many of the bac-teria that express PPO activities are strains that interactwith...

Tài liệu Báo cáo khoa học: "Semantic Parsing with Bayesian Tree Transducers" doc

... percentage of sentences with correct answers),as well as F1: the harmonic mean of precision (theproportion of correct answers out of sentences with a parse) and recall (the proportion of correct ... ithchild of theparent produced by rule m. Aside from ensuringthe grammaticality of the generated MR, rules of this type also model the probability of the MR, con-ditioning the probability of a ... Ψ(r:s(r)=tˆα(r)).493The parameters of q(θt) are deﬁned with respectto q(xi) and the parameters of q(xi) with respectto the parameters of q(θt). q(xi) can be computedefﬁciently...

Tài liệu Báo cáo khoa học: "Word Alignment with Synonym Regularization" doc

... decreased as a result of em-ploying the SRH.We show the performance of GIZA++ and HM-BiTAM with the SRH in the lines entitled with SRH” in Table 1. The GIZA++ and HM-BiTAM with the SRH slightly ... 21872 30294 with SRH 9737 20077 27970Table 2: The number of vocabularies in the 10k,50k and 100k data sets.were replaced with the word ‘sick’. As shown inTable 2, the number of vocabularies ... replac-ing all occurrences of ‘chief’ and ‘forefront’ with ‘head’ do sometimes harm with word alignmentaccuracy, and we have to model either the contextor senses of words.We propose a novel...

Tài liệu Báo cáo khoa học: "Coreference Resolution with Reconcile" pdf

... implementation of the basic ar-chitecture of contemporary state -of- the-art coref-erence systems and a variety of individual mod-ules employed in these systems. Additionally,Reconcile handles all of the ... Reconcile,that can serve as a software infrastructure to sup-port the creation of, experimentation with, andevaluation of coreference resolvers. Reconcilewas designed with the following seven desideratain ... comes with a compre-hensive set of implemented components – thoseavailable for steps 2–5 are shown in Table 2. Rec-oncile contains over 38,000 lines of original Javacode. Only about 15% of the...

Tài liệu Báo cáo khoa học: "Disentangling Chat with Local Coherence Models" pdf

... 11881189Proceedings of the 49th Annual Meeting of the Association for Computational Linguistics, pages 1179–1189,Portland, Oregon,...

Tài liệu Báo cáo khoa học: "Statistical parsing with an automatically-extracted tree adjoining grammar" pdf

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Tài liệu Báo cáo khoa học: "Context Management with Topics for Spoken Dialogue Systems" pptx

... shifts of attention, we seek a formalisation of the information structure of utterances in terms of the new information that is exchanged in the course of the dialogue. The purpose of our ... the erroneous analyses of the initial speech input. 1 The output of a speech recognizer has direct influence on the performance of other mod- ules of the system (dealing with dialogue manage- ... argue in favour of using one type of contextual information, topic information, to maintain robustness of a spoken language system. Our model deals with the information content of utterances,...

Tài liệu Báo cáo khoa học: "The Problem with Kappa" pdf

... that make many of them suspect. One of the key advantages of ROC is that it provides a clear indication of chance level performance as well as a less well known indication of the relative ... we focus on the Kappa family of measures, as well as some closely related statistics named for other letters of the Greek alphabet, and some measures that we will show behave as Kappa measures ... were derived based on analysis of human word association data – the combination of this empirical observation with the place of DeltaP’ as the dichotomous case of 348 Powers’ ‘Informedness’...

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