Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor pptx
Báo cáo khoa học: Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor pptx
... Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor Hu Tao1,2,*, Zhen Zhang2,*, ... sequences of the previously synthesizedLys fragment [24] and its mutants studied in this work. (B,C) The topologic structures of the M4variant of the mung bean trypsin inhibitor (MBTI) Lys fragment ... stronginhibitory activity against trypsin, the Lys fragment of MBTI may also serve as an ideal template for the design of potent, specific and stable furin inhibitors. Here we report the design...
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Báo cáo khoa học: "A RATIONAL RECONSTRUCTION OF THE PROTEUS SENTENCE PLANNER" docx
... provided by the annotator, and encodes much of the information needed by the next stage (case-frame linking). There are four tag-values used - "consequence" (the move is a result of the ... current standards. The program could play a game of "noughts-and-crosses" with a user, then produce a fluent sunmmry of what had happened during the game(whether or not the game was complete). ... network The third (syntactic) component, is a major part of the original Proteus program, and Davey included a very detailed systemic grammar (in the style of Hudson (1971)) for the area of English...
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Tài liệu Báo cáo khoa học: Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural specificity variants doc
... forCav-tRNAArgeven in the absence of either enzyme.In contrast, the half life of Arg-tRNAArgis 46 min.Addition of arginyl-tRNA synthetase from jack bean does not further decrease the stability of the canavany-lated ... from the sequences of the tRNAArgACGgenes from jack bean and soybean werearginylated to only 6–10% of the theoretical acceptanceby the arginyl-tRNA synthetases from both jack bean and soybean, ... into the mechanism of amino acid recognition in the arginine system.ResultsOn the basis of the annotated Arabidopsis genome, weestablished the cDNA sequence of the argS gene of jack bean (accession...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx
... in any of the EREs, irrespective of the absence and presence of E2. Binding of ERa and ERbwas increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced ... possibili-ties. One of the possibilities is that, even if there is anERE, it may not be responsive (not participating in the activation) all of the time, probably because of the presence of other EREs ... 6 h, andanalyzed the status of the binding of all the MLLs toERE1 and ERE2 of the HOXC13 promoter (Fig. 6).As expected, our results demonstrated that binding of each of the MLLs (MLL1–MLL4)...
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Tài liệu Báo cáo khoa học: A novel tachykinin-related peptide receptor of Octopus vulgaris – evolutionary aspects of invertebrate tachykinin and tachykinin-related peptide ppt
... were designed on the basis of the conserved regions, and were used forRT-PCR of first-strand cDNA prepared from the Octopus heart. blast searches of the PCR productsequence showed a high level of ... and the importance of C-terminal Arg-NH2in the specific recognition of TKRPs by TKRPR is conserved through evolutionary lineages of Octopus.Southern blotting of RT-PCR products revealed that the ... confirmed that there was noamplification of traces of the genomic DNA (data notshown).Expression of the cloned receptor in Xenopusoocytes The ORF region of the novel receptor cDNA was amplifiedand...
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Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... 1.10.3.1), but the differentiation between these two types of enzymeis not clear [4]. Looking at the sequences of the twoenzymes, both show absolute conservation of the histi-dine residues of the CuA ... be part of the defense sys-tem against wounding and infection by the pathogen[16]. Thus, the timing and location of melanizationseems to be essential for the prevalence of one of thesetwo ... SDS.Fig. 3. Dependence of the TH activity of extracts of R3 and the two mutant strains on the presence of cofactor,L-dopa. (n) R3; (d)R3-0337–which only expresses the protein NP_519622; (m)R3-1501–which...
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Tài liệu Báo cáo khoa học: N-Methyl-L-amino acid dehydrogenase from Pseudomonas putida A novel member of an unusual NAD(P)-dependent oxidoreductase superfamily ppt
... meth-ylamine are bound to the enzyme in this order, andN-methyl-l-alanine and then NADP+are released from the enzyme. Therefore, the kinetic mechanism of the enzyme is the same as those of conventional ... IV pili [7]. The synthesis of these N-methylated peptides is catalyzed by specificN-methyltransferases such as enniatin synthetase [8]and PilD [9] using S-adenosyl-l-methionine as the methyl group ... region of the P. putida KT2440 genome [37].A 1-kb DNA fragment containing the NMAADH gene wasamplified from the genomic DNA of another P. putidastrain ATCC12633 by PCR with a Perkin–Elmer ThermalCycler...
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Tài liệu Báo cáo khoa học: "Mining User Reviews: from Specification to Summarization Xinfan Meng Key Laboratory of Computational Linguistics " doc
... work of Hu and Liu (2004a) by mapping the extractedfeatures into a hierarchy of features which de-scribes the entity of interest. M. Gamon et al.(2005) clusters sentences in reviews, then ... areusually the same. For example, “dimension”and “size” are different terms, but they share the same unit “mm” or “inch”.Naturally, a product can be viewed as a tree of features. The root is the product ... for everyfeature in the specification tree, and then matchthem to every sentence in the reviews. There mightbe cases that some bi-grams would overlap or con-catenated. In these cases, we join...
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Tài liệu Báo cáo khoa học: "A Method for Correcting Errors in Speech Recognition Using the Statistical Features of Character Co-occurrence" pptx
... improving the understanding of the recognition results. On the other hand, there were four level-down cases. Three of these cases were caused by the misdetection of errors in the SSC procedure. The ... Preparation of Error-Patterns: As the threshold value for the frequency of the occurrence, we employed a value of not less than 2, therefore we obtained 629 Error-Pattems using the 4321 results of ... candidates, when one of their Error-Parts includes the other, and their frequencies are the same value, the candidate whose Error-Part includes the other is accepted. Condition of Inclusion-2:...
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Tài liệu Báo cáo khoa học: "Discovering Global Patterns in Linguistic Networks through Spectral Analysis: A Case Study of the Consonant Inventories" pdf
... correspond-ing to the largest eigenvalue) is the direction inwhich the sum of the square of the projections of the row vectors of the matrix is maximum. Infact, the principal eigenvector of a graph ... threetaken together. The individual contribution of the other eigenvalues to the spectrum is significantlylower than that of the top three. Third, the eigen-values on either ends of the spectrum ... Nevertheless, the work does notstudy the spectrum of the graph. The aim of the present work is to demonstrate the use of spectral analysis for discovering the global patterns in linguistic networks. These...
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