Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx

Báo cáo khoa học: Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol doc

... aids, the assembly of other proteins, but is not part of the final assembly. Later, the focus of chaperone research shifted to the role in the folding of single protein chains and in protecting the ... proteins to be released and passed on to their final destination; misfolded proteins are retro-translocated to the cytosol for disposal. In contrast,most of the proteins that fold in the cytosol ... whilst maintaining the freedom to arrange them according to the needs of the various folding clients provides the ER with the flexibility required for a dynamic and flexible foldingfactory. The ER...

Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf

... stabilityfor crystallins is essential in maintaining lens transparency[4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they canform stable ... concentrations. The d2-crystallin in lens was recruited during evolutionfrom argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cycle. Thesetwo proteins shared ... detectconformational changes of proteins especially in the moltenglobule state [26]. Binding of ANS to the hydrophobicsurface of proteins will lead to ﬂuorescence enhancement aswell as a blue shift in its emission...

$Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf$

Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf

... one of the major causes of transitory diarrhea in the developing world. Toxin bind-ing to its receptor, guanylyl cyclase C (GC-C), results in receptor activation and the production of high intracellularlevels ... areappearance of the 145 kDa form on the cell surface, fol-lowing processing of the endoplasmic reticulum- associatedpool of the 130 kDa form. Selective internalization of the 145 kDa form of the receptor ... desensitization of these receptors. GC-A is phos-phorylated on six serine and threonine residues present in the protein kinase-like domain in the basal state [2].Mutation of any of these sites to alanine...

Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf

... sensitive to proteasome-inducedapoptosis [16]. Although the treatment of cells withthis compound causes marked increases in a largenumber of cellular proteins, including cyclin-dependentprotein kinase ... used to investigate whether ALLN inducedproteasome inhibition in canine chondrocytes. In the absence of ALLN, smears of ubiquitinated proteins were not observed in control and TRAIL-treatedcanine ... range of responses, depending on cell type and levels of ROSwithin the cell [23,24]. The aims of this study were to investigate the majorsignalling pathways and effects of hypoxic conditionsin...

Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx

... to War1p were raised in rabbitsagainst a GST-War1p fusion protein containing 294 aminoacids of the C-terminal part of War1p (amino acids 650–944) fused in- frame to the C-terminus of GST. The ... expression of the C-terminal 294 amino acids of WAR1 fused in- frame to the C-terminus of GST. Escherichia coli strain DH5aharboring pCG1950 was grown on 37 °CtoanA600 of 0.5.Expression of the GST-War1p ... the pool of PCR fragments was subjecteddirectly to DNA sequencing using the BigDye TerminatorCycle Sequencing Kit version 3.0 according to the instruc-tions of the manufacturer and the ABI...

Tài liệu Báo cáo khoa học: "RELATING COMPLEXITY TO PRACTICAL PERFORMANCE IN PARSING WITH WIDE-COVERAGE UNIFICATION GRAMMARS" pptx

... disallowed, then the complexity of the BU-LC parser with respect to the length of the input string is O(np+l), where p is the maximum number of daughters in a rule (Carroll, 1993). The inclusion of ... extract- ing a single analysis from the forest is worse than linear) 5. If one of the features of the ANLT grammar formalism, the kleene operator (allowing indefinite repetition of rule daughters), ... complexity, the CE parser em- ploys a table construction method which ensures that the number of states in the parse table is linearly related to the size of the grammar, resulting in the number of...

Báo cáo khoa học: Death inducer obliterator protein 1 in the context of DNA regulation Sequence analyses of distant homologues point to a novel functional role docx

... found a set of DIDO1 homologues in the context of DNA bindingand chromatin regulation. These homologues includemembers of the CpG binding protein (CGBP) family of proteins that bind DNA at unmethylated ... all appear to have a role in DNA regulation, in the context of chromatin stability, and to form part of higher complexes linked to active chromatin. The DIDO1 gene has been linked to the split ... used inhi-bitor of growth protein 3 (ING3) PHD, which isanother domain involved in chromatin binding andclearly more divergent (e-value 0.019) from DIDO and the other sequences. As the alignment...

Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx

... higherorganisms, this involves storing energy as fat duringperiods of an abundant food supply to hedge againstperiods of food shortage. Today, humans have pushedstorage too far, to the point of widespread ... expenditure. Thus, insulin, leptinand ghrelin, as well as other hormones ⁄ cytokines,interact with their cognate receptors on neurons within the CNS that project to higher brain centers and to peripheral ... from the public health aspects of the affects of fructose on foodintake, these ﬁndings lend further support to the mech-anism by which malonyl-CoA participates in the regu-lation of feeding...

Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt

... expressions of the target language, although, of course, the individual grammars may be com- plicated because of the attuning. • Principle of Interllnguality: There is an intermediate language into ... transformation of the class yields a smaller S-tree according to this measure. The definition of M-GENERATOR is symmetric to the definition of M-PARSER• (There is one appar- ent exception: the condition ... associated, i.e. the S-tree that is the result of the application of the rule of that node on the resulting S-trees of its daughters (see figure I). the donkey is eating apples -the donkey the donkey...

Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt

... mutant proteins results in increased mis-folding of normal proteins and further enhancement of co-aggregation. In this state, the degradation of mis-folded proteins is diminished by their insolubility, ... interact with other proteins. The improvement of microscopic techniques will promote the understanding of the dynamics and toxicity of mis-folded proteins in living cells in the near future.AcknowledgementsAK ... may explain the toxicity of mis-folded proteins. However, a number of studies suggestthat sequestration of misfolded proteins into inclusionsis protective [15]. The total amount of exposed...

Xem thêm